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Bioactive shell-core multiplelayer microstructure nanometer powder and its preparation method

A bioactive, nano-powder technology, applied in prosthesis, medical science and other directions, can solve the problems of poor biological activity, long time for bone defect regeneration and repair, unstable bioactive factors, etc. It is easy to achieve nanometer size and layer structure. The effect of easy control of release rate and excellent safety

Inactive Publication Date: 2006-07-19
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent CN1446591A discloses an injectable calcium phosphate salt paste for filling and repairing bone defects, in order to relieve patients' surgical pain, but the material has poor biological activity and needs more than 2 and a half years to completely degrade in the body
Chinese patent CN1416913 embeds complexes of biologically active factors BMP, FGF, TGF-β, etc. in calcium phosphate salt paste in an attempt to increase the speed of regeneration and repair of defective tissue, but its cost is high, the instability of biologically active factors and Products are not suitable for disinfection and many other shortcomings make it difficult to widely implement clinical application
A porous calcium phosphate ceramic material disclosed in Chinese patent CN1456534 aims to increase the growth rate of new bone tissue and accelerate material degradation. The growth channel is mainly replaced by crawling, and the regeneration and repair time of bone defect is still very long
A nano-scale hydroxyapatite / collagen composite material disclosed in Chinese patent CN1338315 imitates the main inorganic and organic components in the natural bone matrix in terms of composition and structure, and creates the same human bone for the attachment and growth of osteoblasts on the surface of the material. Similar to the microenvironment in the tissue, but the material is insufficient in regulating cell perception, feedback and rapid response, achieving rapid cell proliferation and differentiation, and bone formation-related gene and protein expression. absorb
However, traditional sintering or mechanical mixing methods are difficult to effectively "manage" trace elements and arbitrarily regulate the release rate of active substances in materials (Ito A., J. Biomed. Mater. Res., 2000, 50, 178; Li Y.W., J.Biomed.Mater.Res.2000, 52, 164), although the sol-gel preparation technology developed in recent years can significantly improve the uniformity of each component, it is still unable to carry out the trace elements in the material. Effectively manage and arbitrarily regulate the release rate of trace elements

Method used

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  • Bioactive shell-core multiplelayer microstructure nanometer powder and its preparation method
  • Bioactive shell-core multiplelayer microstructure nanometer powder and its preparation method
  • Bioactive shell-core multiplelayer microstructure nanometer powder and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Preparation of Silica@Zn-Sr@OCP 35 Nano powder

[0037] (1) Preparation of gel nanosphere powder:

[0038] In 17.8mL absolute ethanol medium, add 0.72mL ammonia water and 0.58mL deionized water successively under the condition of magnetic stirring, then add 0.9mL tetraethyl orthosilicate to the above mixed solution, and put the silica sol solution at 25°C Stirring was continued for 6 hours. Then, adopt centrifugal filtration method (4000rpm) to carry out solid-liquid separation, ultrasonically disperse and wash with deionized water, and centrifuge again to remove unhydrolyzed and polymerized silica sol, and dry under vacuum at 60°C for 24 hours to obtain silica gel nanospheres ( Such as figure 1 a spectrum and figure 2 a photo).

[0039] (2) Gel nanosphere layer-layer assembly of zinc and strontium ions:

[0040] Add 240mg of silica gel nanospheres to 5.0mL of ionized water, ultrasonically disperse, add 200mL of zinc nitrate aqueous solution with a conc...

Embodiment 2

[0043] Example 2 Preparation of Silica@Zn@OCP 40 Nano powder

[0044] (1) Preparation of gel nanosphere powder:

[0045] Operate with step (1) in Example 1.

[0046] (2) Gel nanosphere layer-layer assembly of zinc ions:

[0047] Add 120mg of Silica nanospheres to 2.5mL of ionized water, ultrasonically disperse, add 100mL of zinc nitrate aqueous solution with a concentration of 5mmol / L, adjust the pH value to 8.2, and stir rapidly for 6 hours. Zinc ions are adsorbed on the surface of Silica nanospheres, and centrifugally filtered. Then, add the nano-powder with zinc ions adsorbed to 5mL of absolute ethanol medium, ultrasonically disperse, add 0.2mL of ammonia water, 0.2mL of deionized water and 0.08mL of ethyl orthosilicate under the condition of magnetic stirring, and the The suspension was stirred at 35°C for 6 hours, and filtered by centrifugation. Repeat the above steps for adsorption and wrapping three times to obtain multilayer nanospheres with zinc ions wrapped in si...

Embodiment 3

[0050] Example 3 Preparation of Silica@Sr@OCP 40 Nano powder

[0051] (1) Preparation of gel nanosphere powder:

[0052] Operate with step (1) in Example 1.

[0053] (2) Preparation of gel nanosphere layer-layer assembly of strontium ions and Silica@Sr@OCP:

[0054]Zinc nitrate aqueous solution is changed into strontium nitrate aqueous solution in the embodiment 2 step (2), and the adjustment pH value is 8.2 and the adjustment pH value is 9.6 instead, and other operations are with step (2) and (3) in the embodiment 2, can Preparation of bioactive nanopowder Silica@Sr@OCP which is coated with hydrated calcium hydrogen phosphate and encapsulated silica gel nanospheres and assembled with strontium ions 40 (40 represents the molar ratio of Silica to OCP).

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Abstract

The invention discloses a multilayer microstructure nanometer powder body of biological active shell-core, which is characterized by the following: adapting silicon gel as inner core and porous calcium phosphate as outer shell; allocating spherical particle of multilayer microelement zinc or and strontium ion between shell and core; letting ammonia catalyze hydrolysis of ethyl silicate and polycondense into silicon gel nanometer ball in the absolute ethyl alcohol; mixing the zinc or strontium ion solution with the suspending solution of silicon gel nanometer ball; attaching the zinc or strontium ion to the silicon gel nanometer ball and micropore domain; packing the silicon gel layer and zinc or strontium ion; depositing the porous calcium phosphate on the silicon gel nanometer ball surface; filtering; drying; adjusting the releasing speed of inner core active material through changing the microstructure of outer shell; diminishing the explosive releasing behavior of active silicon, strontium and zinc during short period.

Description

technical field [0001] The invention relates to a bioactive shell-core multilayer microstructure nanopowder material and a preparation method thereof, belonging to the field of biomedical materials for repairing human tissue damage. Background technique [0002] The rapid and complete regenerative repair of bone defects such as bone and tooth tissue defects caused by trauma, tumor resection and inflammation-induced bone and tooth tissue necrosis has always been one of the difficult problems in clinical medicine. Since the early 1970s, Hench first reported a CaO, SiO 2 ,P 2 o 5 and Na 2 The bioactive glass powder material (trade name: 45S5 Bioglass®) fired from the compound of the O component can form a chemical bond (osseointegration) with human bone and tooth tissue. Since the research on bioactive materials has a history of more than 30 years . So far, people have also found that many calcium-phosphorus (CaO-P 2 o 5 ) or calcium-silicon (CaO-SiO 2 )-based inorganic...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/42
Inventor 苟中入翁文剑
Owner ZHEJIANG UNIV
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