Process and materials for the rapid detection of streptococcus pneumoniae employing purified antigen-specific antibodies

a technology of streptococcus pneumoniae and purified antigens, applied in the direction of antibody medical ingredients, instruments, peptides, etc., can solve the problems of lack of sensitivity and/or specificity, time-consuming, labor-intensive, etc., and achieve rapid diagnosis of pneumonia, heightened risk of recurrence and subsequent death, and easy to perform
US20080241191A1Inactive Publication Date: 2008-10-02ALERE SCARBOROUGH
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
ALERE SCARBOROUGH
Publication Date
2008-10-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

Disclosed is a cell wall C-polysaccharide antigen of Streptococcus pneumoniae which contains not more than 10% by weight of protein, and preferably less which has been purified with 0.1N NaOH prior to deproteinizing. Also disclosed are polyvalent antibodies raised against Streptococcus pneumoniae which have been affinity purified by passing them over a chromatographic affinity matrix to which is coupled the purified and at least partially deproteinized antigen to render them antigen-specific.
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Description

PARENT APPLICATION

[0001] This application is a division of U.S. application Ser. No. 09 / 397,110 filed Sep. 16, 1999, which is in turn a continuation in part of U.S. application Ser. No. 09 / 156,486 filed Sep. 18, 1998 in the names of the same inventors.BRIEF DESCRIPTION OF THE INVENTION

[0002] The present invention relates to a purified carbohydrate antigen of S. pneumoniae and its use in affinity purifying antibodies raised in an animal against S. pneumoniae bacteria or against the carbohydrate antigen. The affinity purified antibodies are especially useful in a specific and sensitive immunochromatographic (“ICT”) assay, performable within about 15 minutes, for the detection of Streptococcus pneumoniae in a bodily fluid, such as urine or cerebrospinal fluid, of a patient showing clinical signs of an infection caused by S. pneumoniae. BACKGROUND OF THE INVENTION

[0003] Streptococcus pneumoniae (“S. pneumoniae”) is a leading causative organism of pneumonia-type illnesses and other lower re...

Claims

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