66results about "Material analysis using immobilised reagents" patented technology

A device, system and method for portable fluorescence detection. The portable device of the present invention features a low power light, in which a wavelength range is defined as at least one wavelength of light. The light source is preferably highly energy efficient, such that a majority of the electrical power which is consumed is then converted into transmitted light. The emitted light from the excited fluorophore is then preferably detected with any low cost and low power photodetector. Although optionally a highly sensitive optical detector may be used, preferably fluorescence is detected with any light sensing device, such as a regular photodiode or a CCD (charge-coupled device) sensor for example.

A change in mass of a microbridge in a mass sensor can be sensed by applying a time-varying amplitude modulated electrostatic force to excite the microbridge into resonance at the frequency of amplitude modulation. An optical energy is then transmitted at a wavelength close to a resonant wavelength of a Fabry-Perot microcavity, which is formed by etching a movable reflective mirror into a region of the microbridge and by etching a fixed reflective minor in a region spaced apart from the microbridge. The two mirrors are interconnected by an optical waveguide. The movable mirror and fixed mirror reflect the optical energy to a receiver, and a change in the Fabry-Perot microcavity's reflectivity is interferometrically determined. The change in reflectivity indicates a change in the microbridge's resonant frequency due to increased mass of the microbridge resulting from sorption of a target chemical by a layer of chemoselective material deposited on the microbridge.

A symmetric or asymmetric multilayer structure based on the technique of surface plasmon resonance (SPR) has been applied for modulation of resonant angle and wavelength. The fabrication of this invention can have nanoscale thin film layers up to several hundreds, while each layer has its own material of a high or low refractive index value, and the total layers in a thickness of tens to hundreds nanometers are grown in this single structure. This invention is intended for optimizing the scanning of mechanism by modulating SPR resonant angle and wavelength, and for developing the prospect of portable instruments.

A testing device for identifying an antigen or antibody within a biofluid sample including: a substrate having a hydrophilic surface thereon; the surface including a collection zone, and at least one detection zone extending therefrom; wherein the biofluid sample can be mixed with a specific antigen or antibody, and deposited on the collection zone and transferred by capillary action to the detection zone; the antigen or antibody in the biofluid sample reacting with an appropriate said antibody or antigen thereby resulting in a visual indication within the detection zone.

Polydiacetylenes (PDAs) and PDA/ZnO nanocomposites based on the monomers: 10,12-pentacosadiynoic acid (PCDA), 10,12-tricosadiynoic acid (TCDA) and 10,12-docosadiynedioic acid (DCDA) monomers are chromatic chemical sensing agents for selected organic liquids. Thermochromically reversible compositions include PCDA and nanosize ZnO having a particle size range less than 100 nm.

Differing from conventional lateral flow immunoassay test strips, the present invention provides an immunoassay kit comprising a release strip and a reaction strip. When using this immunoassay kit to complete a competitive-type immunochromatographic test or a sandwich-type immunochromatographic test for a test sample, it needs to firstly put the release strip into the test sample for releasing a specific antibody (or antigen) conjugating with a marker into the test sample, so as to make the first antibody connect to a target object in the test sample; after that, the reaction strip is eventually put into the test sample after the release strip is removed out of the test sample. Therefore, the qualitative analysis result of the competitive/sandwich-type immunochromatographic test can be easily obtained by determining whether the test line shows the color reaction or not.

The invention relates to a Pd quantum dot-modified TiO2 nanorod-based photoelectric chemical analysis method and application thereof. By means of making a relational diagram of the concentration of a standard PCB 101 solution and current, the concentration of PCB 101 in a to-be-measured solution can be obtained. Compared with the prior art, by constructing a Pd quantum dot-modified TiO2 nanorod with efficient photoelectric catalytic reduction activity, the method realizes efficient reduction for the PCB 101, obtains sensitive cathode photocurrent and realizes photoelectric chemical detection for the PCB 101; furthermore, due to the introduction of molecularly imprinted loci and the establishment of a reaction type analysis method, the selectivity of the analysis method is further improved, and the interference of coexisting easily oxidized pollutants in environmental water with PCB 101 detection is greatly reduced. The method is simple and easy to implement and high in sensitivity, has a limit of detection reaching up to 10-13mol/ L, is stable in electrodes and has good reproducibility.

An electrogenerated chemiluminescence (ECL) probe is based on trititanium dicarbide two-dimensional (2D) metal carbide catalyzed luminol and a preparation method. The biosensor includes the probe and the electrode of the biosensor, wherein the probe includes the Ti₃C₂ MXenes nanosheets, a linker molecule and a bio-recognition molecule 1; the Ti₃C₂ MXenes nanosheets are linked with the linker molecule by electrostatic adsorption; the linker molecule is linked with the bio-recognition molecule 1 by an amide group, contains a primary or secondary amine group, and presents positive potential in water; the bio-recognition molecule 1 is a single-stranded DNA sequence 1 having a carboxyl group at the 5′ end, and a CD63 protein on exosomes is recognized by the single-stranded DNA sequence 1. It was found for the first time that Ti₃C₂ MXenes can improve the ECL signal of luminol, the Ti₃C₂ MXenes could be applicable to the ECL probe.

The present invention relates to a device and a method for qualitative and quantitative analysis of heavy metals and more particularly provides a device and a method for qualitative and quantitative analysis of heavy metals utilizing a rotary disc system.

Lateral flow devices and methods of use for a molecular diagnostic assay are provided. The method is suitable for detection or monitoring of targets, including biological, chemical, and material targets that exist in very low concentrations in biological samples. The methods and devices of the present application are amenable to power source-free point of care testing.

Measuring oxygen concentration and monitoring changes in oxygen concentration within an enclosed space by applying a transmembrane photoluminescent oxygen probe to the external surface of the membrane forming the enclosed space, wherein the transmembrane photoluminescent oxygen probe has an oxygen impermeable support layer carrying a spot of an oxygen-sensitive photoluminescent dye and a layer of a pressure-sensitive adhesive on a first major surface of the support layer.

A lateral flow assay format test that accepts a saliva sample that is reacted with a conjugate to indicate the level of testosterone present in the saliva sample. The concentration of testosterone is used to determine the likelihood of the saliva donors commitment to an interpersonal relationship.

The present invention provides for a method of optimisation of a polynucleotide sequence for use in an aptamer based assay, comprising adding additional bases to the ligand binding domain. The invention also covers methods of detecting target molecules in a sample using 5 optimised polynucleotide sequences in a suitable detection assay.