The present invention relates to a sound zone control device and method in a vehicle, a controller and a medium. The device includes a main control module, a power amplifier module and a plurality of directional transmission modules. There is a channel between the power amplifier module and each directional transmission module. The transmission module corresponds to a sound area in the car; the main control module is configured to determine the channel to be sent by the audio signal, obtain the channel number to be sent, and send the channel number and the audio signal to the power amplifier module; the power amplifier module is configured to transmit the audio signal The signal is amplified by a preset multiple, and the amplified audio signal is sent to the directional transmission module corresponding to the channel number to be sent; the directional transmission module is configured to directional transmit the amplified audio signal to the corresponding sound area. Based on the strong directivity of the parametric loudspeaker, the invention realizes the directional transmission of the sound, so that the driver and passengers in the car only receive the sound related to it, which is simple and easy to implement, has strong adaptability to the whole vehicle environment, and has wider and more flexible applications.