The invention discloses a technique for manufacturing a high alloy steel seamless pipe with heavy calibre by adopting a pilger mill, comprising: a hollow shell is made by centrifugal casting; the outside surface of the front end of the hollow shell is processed to be a 'gripping head' with conicity, and machining and quality inspection are carried out on the inside and the outside surfaces aswell as the 'gripping head' of the hollow shell; the tail end of the hollow shell is welded with a plain carbon steel ring-shaped part; heating and dephosphorization are carried out on the hollow shell; a mandril is inserted into the heated and dephosphorized hollow shell and the hollow shell is located, and then the hollow shell is sent into the pilger mill for alternate rolling, so that the pipefittings in accordance with the requirements can be produced; the mandril of the pipe fittings is removed, and the head and the tail are cut off; finally, the qualified finished pipes can be obtainedafter heating, sizing and finishing operation. As the steps of punching and hole expanding are omitted, the process flow is shortened, and the running cost is reduced; the step of reheating is reduced, so that the energy can be saved; the hollow shell is obtained by centrifugal casting and is machined, so that the quality of the product can be improved; as the plain carbon steel ring-shaped partis welded at the tail of the hollow shell, the material consumption of precious metal is reduced, and the yield is greatly improved; furthermore, a section of 'gripping head' with small conicity is processed at the front end in advance, thus facilitating the gripping of rolling and improving the operation efficiency and the stability of rolling.