The invention relates to a titanium alloy, in particular to a titanium alloy TC4 hot-rolled tube and a production method thereof. By weight, the composition of the alloy is as follows: the balance of Ti, 5.5 percent to 6.75 percent of Al, 3.5 percent to 4.5 percent of V, less than or equal to 0.1 percent of Fe, less than or equal to 0.1 percent of C, less than or equal to 0.03 percent of N, less than or equal to 0.015 percent of H and less than or equal to 0.15 percent of O. A tube blank is heated and rolled on line, the on-line heating temperature is 600 DEG C to 1200 DEG C, and is kept for 1 to 45 minutes, the deformation at each pass is 15 percent to 85 percent, the rolling speed is 20 to 90 times/min, a finished product is produced after 1 to 10 times of rolling, the rolled finished product is annealed in oxygen or vacuum, the annealed finished product is washed by alkali and acid or acid and then by water, and thereby the product is obtained. The tensile strength of the titanium alloy tube is 895MPa to 1300MPa, the elongation of the titanium alloy tube is 8 percent to 25 percent, the metallographic structure is uniform, and a stress-relief annealed metallographic structure and a fully recrystalization annealed metallographic structure can be obtained.