The invention discloses a disperse dye with high washing fastness and a preparation process thereof. According to the key point of the technical scheme, the dye is prepared from the following components in parts by mass: 50 to 60 parts of C.I. Direct yellow 106 dye, 30 to 40 parts of plant extract, 50 to 60 parts of o-phenylphenol, 20 to 30 parts of methyl salicylate, 30 to 40 parts of hematoxylin, 4 to 8 parts of dibenzodioxazine, 3 to 8 parts of cyanuric chloride, 5 to 10 parts of anti-deposition agent, 4 to 8 parts of dispersant, 3 to 8 parts of surfactant, 5 to 6 parts of stabilizer and 7 to 10 parts of bacteriostatic agent. The disperse dye with high washing fastness is not easy to decolor and oxidize during use, and has excellent washing fastness; the preparation process of the disperse dye with high washing fastness is simple in steps, the vegetable red dye is adopted as one of main components, the yellow color is natural, the cost is low, and the disperse dye has a wide application prospect.