The invention relates to a medical instrument, in particular to a glass ampoule bottle opener. A glass ampoule bottle opener, comprising a plate body, characterized in that: a bottle body fixing device is arranged on the plate body, and a circular boss of the bottle body fixing device is rotatable with the circular boss as the center of the circle. A bottle neck cutting device is provided, and the central position of the circular boss is rotatably provided with a bottle neck hitting device; the bottle fixing device includes a circular boss, an annular groove, a bottle body fixing splicing piece I, a half A circular groove, a bottle body fixing splicing piece II and a locking screw; the bottle neck cutting device includes a column, a bottle neck cutting mechanism, a casing and a grinding wheel disk; the bottle neck hitting device includes a rotating disk, a bottle neck hitting mechanism , strike seat, chute, slide bar, strike lever, strike port, clamping lever chute, clamping lever, trigger mechanism and trigger lever. In the present invention, since the hands of the medical staff do not directly contact the ampoule bottle, it is safer to open the ampoule bottle.