The invention discloses hard hydrolysis-resistant, low-pitting performance and strong-peel strength polyurethane resin and a preparation method thereof. The preparation method is characterized by comprising the following steps of adding an organic solvent, macromolecular dihydric alcohol, a chain extender, an antioxidant and a part of isocyanate into a reaction kettle according to a proportion, performing reaction for 1 to 2 hours under 60 to 80 DEG C and normal pressure, adding an organic tin or bismuth catalyst, preserving heat, feeding the residual isocyanate in batches into the reaction kettle, supplementing the organic solvent in batches according to the viscosity condition of a reaction system until the viscosity of a product is 80 to 120Pa.s/25 DEG C, and finally adding a reaction termination agent to obtain a hard hydrolysis-resistant, low-pitting performance and strong-peel strength polyurethane resin product with solid content of 35 to 40 percent. The prepared resin is applied to the production of synthetic leather, and a produced leather product has a solid hand-feel, high hydrolysis resistance and low pitting performance.