The invention relates to an orthopedic appliance, in particular to a multiple anti-motion leg fixing device. The multiple anti-motion leg fixing device comprises a transverse base, a T-shaped slidingrail, arc-shaped frames, arc-shaped sliding grooves, bosses, spring loop bars, clamping plates, square columns, rectangular holes and limiting round pins. The multiple anti-motion leg fixing device has the advantages that the leg can be clamped and fixed, and the leg can be slightly twisted while clamping to achieve a rehabilitation training effect. The upper end of the transverse base is providedwith the T-shaped sliding rail, the two arc-shaped frames are arranged front and back and are provided with the arc-shaped sliding grooves respectively, the two arc-shaped frames are slidably connected to the front and rear ends of the T-shaped sliding rail respectively, the upper and lower ends of the outer sides of the two arc-shaped frames are fixedly connected with the bosses respectively, each spring loop bar is fixedly connected between the two bosses on the same arc-shaped frame, the two spring loop bars are in sleeved connection with two compression springs, the two clamping plates are arranged front and back, the outer sides of the two clamping plates are fixedly connected with the square columns respectively, the two square columns are inserted in the two arc-shaped sliding grooves respectively, and the two square columns are fixedly connected with the two limiting round pins respectively.