Cysteine/ferroferric oxide/copper sulfide/BSA (bovine serum albumin) nano-composite particle as well as preparation and application thereof
A technology of nanocomposite particles and bovine serum albumin, which is applied in the direction of non-active components of polymer compounds, wave energy or particle radiation treatment materials, drug combinations, etc., can solve problems such as obvious side effects of the human body, damage to normal tissues, and poor water solubility. Achieve the effects of shortening the preparation cycle, good biocompatibility, and low cost
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Embodiment 1
[0042] A kind of cysteine / ferric oxide / copper sulfide / bovine serum albumin nanocomposite particle, with BSA binding cysteine to modify Fe 3 o 4 , CuS nanocrystals are the shell, and the inner space is used to load anticancer drugs (such as PTX) that are poorly soluble in water. The loading ratio of the nanocomposite particles to PTX is 5%-9%.
[0043] The preparation method of the cysteine / ferric oxide / copper sulfide / bovine serum albumin nanocomposite particles comprises the following steps:
[0044] (1) Magnetic Fe 3 o 4 The particles are prepared according to the traditional co-precipitation method: 1.4g of FeCl 2 4H 2 O and 2.0 g FeCl 3 ·6H 2 O was added with 100 mL of deionized water, stirred vigorously under the protection of nitrogen and heated to 50°C, then quickly added 30 mL of ammonia water, and the solution was heated to 80°C and kept for 2.5 hours. Then it was cooled to room temperature, and a black precipitate was obtained by adding an external magnet, w...
Embodiment 2
[0059] A kind of cysteine / ferric oxide / copper sulfide / bovine serum albumin nanocomposite particle, described nanocomposite particle is made of Cys, Fe 3 o 4 , CuS and BSA form a shell structure, in which Cys modifies Fe 3 o 4 Afterwards, CuS is combined with BSA to form a shell through disulfide bond, CuS is adsorbed with BSA, and the space in the shell is used to load the anticancer drug PTX which is poorly soluble in water, and the diameter of the nanocomposite particles is about 300nm.
[0060] The preparation method of the above-mentioned cysteine / ferric oxide / copper sulfide / bovine serum albumin nanocomposite particles comprises the following steps:
[0061] (1) Take Fe 3 o 4 Ultrasonic dispersion of nanoparticles in PBS (0.02M, pH6.0), then adding cysteine aqueous solution, ultrasonication, then adding carbodiimide hydrochloride, keeping in a water bath at room temperature, stirring, centrifuging, and washing, to obtain Cys- Fe3 o 4 , dispersed in deionized water ...
Embodiment 3
[0074] A kind of cysteine / ferric oxide / copper sulfide / bovine serum albumin nanocomposite particle, described nanocomposite particle is made of Cys, Fe 3 o 4 , CuS and BSA form a shell structure, in which Cys modifies Fe 3 o 4 Afterwards, CuS is combined with BSA to form a shell through disulfide bond, CuS is adsorbed with BSA, and the space in the shell is used to load the anticancer drug PTX which is poorly soluble in water, and the diameter of the nanocomposite particles is about 300nm.
[0075] The preparation method of the above-mentioned cysteine / ferric oxide / copper sulfide / bovine serum albumin nanocomposite particles comprises the following steps:
[0076] (1) Take Fe 3 o 4 Ultrasonic dispersion of nanoparticles in PBS (0.02M, pH6.0), then adding cysteine aqueous solution, ultrasonication, then adding carbodiimide hydrochloride, keeping in a water bath at room temperature, stirring, centrifuging, and washing, to obtain Cys- Fe 3 o 4 , dispersed in deionized wate...
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