Preparation method of high-biological activity support material

A bioactive, scaffold material technology, applied in the field of artificial bone repair materials, can solve the problems of low bioactivity, poor plasticity, slow cell proliferation rate, etc., achieve good degradation performance, high chemical reactivity, and improve biocompatibility Sexual and Bioactive Effects

Inactive Publication Date: 2018-08-24
常州市蒽盗钟情生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The technical problem mainly solved by the present invention is that the in vivo degradation of current materials is uncontrollable, and the degradation products are easy to cause inflammatory reactions. The single use of polymer or ceramic materials as scaffold materials has poor plasticity, low biological activity, and slow cell proliferation rate, which cannot meet the requirements. Requirements for load-bearing bone repair deficiencies, providing a method for the preparation of highly bioactive scaffold materials

Method used

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  • Preparation method of high-biological activity support material

Examples

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example 1

[0027] Put the titanium sheet in an ultrasonic cleaning machine, wash it with absolute ethanol and acetone for 15 min in turn, control the ultrasonic frequency to 35 kHz, put the cleaned titanium sheet in an oven with a set temperature of 80 ° C for 5 h, and then transfer it to a 15mL of sodium hydroxide solution with a mass fraction of 40% in an autoclave, heated to 240°C, and kept for 8 hours to obtain a titanium-based titanate nanowire matrix; 0.3g of graphite powder and 0.13g of sodium nitrate were added to the In a beaker with 12 mL of concentrated sulfuric acid solution with a mass fraction of 85%, place the beaker in an ice-water bath, stir for 45 min, remove the ice-water bath and stir for 2 h at room temperature, add 15 mL of deionized water and 25 mL of deionized water to the beaker with a mass fraction of 10 % hydrogen peroxide, continue to stir the reaction until no bubbles are produced; continue to add 25mL of sulfuric acid solution with a mass fraction of 8% and 1...

example 2

[0029] Put the titanium sheet in an ultrasonic cleaning machine, wash it with absolute ethanol and acetone for 13 minutes in sequence, control the ultrasonic frequency to 33 kHz, put the cleaned titanium sheet in an oven with a set temperature of 75°C for 4.5 hours, and then transfer it to a container. In an autoclave with 13mL of 40% sodium hydroxide solution, heat up to 220°C and keep the temperature for 7.5h to obtain a titanium-based titanate nanowire matrix; add 0.25g of graphite powder and 0.12g of sodium nitrate Put 11 mL of concentrated sulfuric acid solution with a mass fraction of 85% in a beaker, place the beaker in an ice-water bath, stir for 38 min, remove the ice-water bath and stir for 1.5 h at room temperature, add 13 mL of deionized water and 23 mL of mass to the beaker 10% hydrogen peroxide, continue to stir until no bubbles are produced; continue to add 23mL of sulfuric acid solution with a mass fraction of 8% and 13mL of hydrogen peroxide with a mass fractio...

example 3

[0031] Put the titanium sheet in an ultrasonic cleaning machine, wash it with absolute ethanol and acetone for 15 min in turn, control the ultrasonic frequency to 35 kHz, put the cleaned titanium sheet in an oven with a set temperature of 80 ° C for 5 h, and then transfer it to a 15mL of sodium hydroxide solution with a mass fraction of 40% in an autoclave, heated to 240°C, and kept for 8 hours to obtain a titanium-based titanate nanowire matrix; 0.3g of graphite powder and 0.13g of sodium nitrate were added to the In a beaker with 12 mL of concentrated sulfuric acid solution with a mass fraction of 85%, place the beaker in an ice-water bath, stir for 45 min, remove the ice-water bath and stir for 2 h at room temperature, add 15 mL of deionized water and 25 mL of deionized water to the beaker with a mass fraction of 10 % hydrogen peroxide, continue to stir the reaction until no bubbles are produced; continue to add 25mL of sulfuric acid solution with a mass fraction of 8% and 1...

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Abstract

The invention relates to the technical field of preparation of artificial bone repair materials in the field of inorganic nonmetallic materials and biomedical materials, in particular to a preparationmethod of a high-biological activity support material. The preparation method of the high-biological activity support material, provided by the invention, comprises the following steps: a titanium-based titanate nano-wire matrix is made of a titanium sheet, homemade solid graphene oxide is configured into turbid liquid, a graphene nano-sheet suspension is obtained by adding sodium hydroxide, chloroacetic acid and other substances through ultrasonic dispersion, and the titanium-based titanate nano-wire matrix is subjected to electrophoretic deposition with deposition liquid to obtain the high-biological activity scaffold material. Graphene oxide is deposited and modified on the surface of the matrix, so that the biocompatibility and the biological activity of the support material are improved; a coating solution used is a silk fibroin stock solution and casein, is high in degradation property and does not produce any toxic substance; and through the functionalization of the chloroacetic acid, 1,3-propylenediamine and the like for hydroxyl, amino and carboxyl of the graphene oxide, the bone induction ability of a unfunctionalized support material is further improved, and therefore,the application prospect is wide.

Description

technical field [0001] The invention relates to the technical field of preparation of artificial bone repair materials in the field of inorganic non-metallic materials and biomedical materials, in particular to a preparation method of a high bioactivity scaffold material. Background technique [0002] Diseases, trauma, population aging and natural disasters can all lead to damage to human bone tissue, and there is a huge demand for bone repair materials in clinical practice. However, autologous bone grafting, which is the golden rule, is far from being able to meet the status quo due to its limited source and the pain of secondary surgery for patients. Allograft bone transplantation also has biological safety hazards, which may leave patients with lifelong immune rejection and bring unknown diseases. Therefore, artificial preparation of bone repair materials has received more and more attention clinically. [0003] The process of tissue regeneration and repair is to inocul...

Claims

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Application Information

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IPC IPC(8): A61L27/02A61L27/08A61L27/22A61L27/56A61L27/58
CPCA61L27/025A61L27/08A61L27/227A61L27/56A61L27/58A61L2400/12A61L2400/18A61L2430/02C08L89/00
Inventor 雷红军何伟仁张建初
Owner 常州市蒽盗钟情生物科技有限公司
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