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Method for constructing medical titanium alloy surface for promoting growth and differentiation of bone marrow mesenchymal stem cells

A titanium alloy, time technology, applied in medical science, metal material coating technology, prosthesis and other directions, can solve the problems affecting the growth and differentiation of bone marrow mesenchymal stem cells, the chemical covalent binding force between the dopamine transition layer and the titanium surface needs to be improved, There is no good improvement of surface roughness and wettability, etc., and the treatment method is simple and feasible, which is beneficial to adhesion, and improves the roughness and surface wettability.

Active Publication Date: 2020-08-14
SHANGHAI JIAOTONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the chemical covalent binding force between the transition layer of dopamine and the titanium surface in this method needs to be improved.
In addition, since the graphene oxide coating prepared by the patented method on the surface of the titanium alloy does not improve the surface roughness and wettability, this will affect the bone marrow mesenchymal stem cells on the surface to a certain extent. growth differentiation

Method used

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  • Method for constructing medical titanium alloy surface for promoting growth and differentiation of bone marrow mesenchymal stem cells
  • Method for constructing medical titanium alloy surface for promoting growth and differentiation of bone marrow mesenchymal stem cells
  • Method for constructing medical titanium alloy surface for promoting growth and differentiation of bone marrow mesenchymal stem cells

Examples

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Embodiment 1

[0048] This example provides a method for constructing a medical titanium alloy surface to promote the growth and differentiation of bone marrow mesenchymal stem cells.

[0049] The titanium alloy sample used in this example is a medical titanium alloy plate, the raw material is Ti-6Al-4V alloy, and the graphene oxide used is obtained by modifying graphene by the modified Hummers method. The preparation method comprises the following steps:

[0050] (1) The surface of the Ti-6Al-4V alloy was mechanically polished, and the surface roughness was measured to be 0.1 μm. It was ultrasonically cleaned in acetone and aqueous solution for 30 minutes, and the surface was blown dry with nitrogen after cleaning three times. The microstructure of the untreated titanium alloy surface refer to figure 1 ;

[0051] (2) Ultraviolet laser nanolaser (wavelength 355nm) is used to groove the surface of Ti-6Al-4V alloy. The textured groove parameters are: width 45μm, depth 10μm, spacing 100μm. T...

Embodiment 2

[0061] This example provides a method for constructing a medical titanium alloy surface to promote the growth and differentiation of bone marrow mesenchymal stem cells. The preparation method comprises the following steps:

[0062] (1) The surface of the Ti-13Nb-13Zr alloy was mechanically polished, and the surface roughness was measured to be 0.5 μm. The surface was cleaned with acetone and aqueous solution ultrasonically three times, and then the surface was dried with nitrogen.

[0063] (2) The surface of Ti-13Nb-13Zr alloy was grooved by ultraviolet laser nanolaser (wavelength 355nm). The textured groove parameters were: width 10 μm, depth 5 μm, spacing 20 μm. The pulse frequency used in the texturing process is 70kHz, the laser speed is 100mm / s, and the laser power is 0.6W. The roughness of this surface was measured to be 8.93 μm.

[0064] (3) The grooved Ti-13Nb-13Zr alloy was washed three times with acetone and deionized water, and dried with nitrogen gas; it was acti...

Embodiment 3

[0072] This example provides a method for constructing a medical titanium alloy surface to promote the growth and differentiation of bone marrow mesenchymal stem cells. The preparation method comprises the following steps:

[0073] (1) The surface of the Ti-6Al-7Nb alloy was mechanically polished to a roughness of about 0.9 μm. It was ultrasonically cleaned three times with acetone and deionized water, and then dried with nitrogen.

[0074] (2) A laser micromachining system was used to process microgroove patterns on the surface of the Ti-6Al-7Nb alloy, and the parameters were: width 70 μm, depth 20 μm, and spacing 100 μm. The pulse frequency used in the texturing process was 30 kHz, the laser speed was 300 mm / s, and the laser power was 1.8 W. The roughness of this surface was measured to be 7.74 µm.

[0075] (3) Wash the grooved Ti-6Al-7Nb alloy three times with acetone and deionized water, and dry at room temperature; put piranhaic acid (V 浓硫酸 / V 过氧化氢 =7:3) for 5 minutes...

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Abstract

The invention provides a surface construction method for a medical titanium alloy of promoting growth and differentiation of a bone marrow mesenchyml stem cell. The method comprises the following steps: S1, grooving the surface of a test sample by using ultraviolet nano laser after mechanically polishing and degreasing the surface of the test sample; and S2, assembling a graphene oxide coating tothe surface of a substrate by using a silane coupling agent and dopamine double transitional layers, wherein the S2 comprises the following steps: treating the test sample in an strong acid and strongalkali solution and exposing the test sample to an ultraviolet light for a certain time; putting the test sample in a silane coupling agent aqueous solution to assemble a silane transitional layer; taking out the test sample and putting the test sample in a dopamine solution to assemble a dopamine transitional layer; taking out the test sample and cleaning the test sample, and immersing the testsample in a graphene oxide aqueous solution to prepare the graphene oxide coating. Compared with the prior art, the method improves the roughness and wettability of the surface of the titanium alloy and enhances the bonding strength between the coating and the substrate. The surface of the titanium alloy is more favorable for growth and differentiation of the bone marrow mesenchyml stem cell.

Description

technical field [0001] The invention belongs to the field of surface processing and coating preparation of medical devices, and relates to a method for promoting the growth and differentiation of bone marrow mesenchymal stem cells on the surface of medical titanium alloys, in particular to a method for promoting bone marrow mesenchymal stem cells on the surface of medical titanium alloy materials A surface construction method for adhesion proliferation differentiation. Background technique [0002] Titanium and titanium alloy materials, due to their low elastic modulus, excellent mechanical properties, excellent corrosion resistance and biocompatibility, have been widely used in dentistry and plastic surgery, and are ideal bone implant materials . The surface properties of titanium implants are the key factors for rapid and stable bone tissue integration. Poor osseointegration leads to aseptic loosening of implants and further shortens their service life. Due to the poor b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C26/00A61L27/06A61L27/30
CPCA61L27/06A61L27/306A61L2420/02C23C26/00
Inventor 赵世昌王宸宸张亚东任天辉徐勇邓珺
Owner SHANGHAI JIAOTONG UNIV
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