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Diagnostic method for aesthetic deterioration of skin

A diagnostic method and skin technology, applied in biochemical equipment and methods, disease diagnosis, scientific instruments, etc., can solve problems such as dull complexion, pigment disorder, deposition, etc.

Pending Publication Date: 2022-04-01
LOREAL SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] These pollutants will notably on the skin cause the deposition of particles on the epidermal surface and, among other consequences, cause dull complexion and / or pigment disturbances

Method used

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  • Diagnostic method for aesthetic deterioration of skin
  • Diagnostic method for aesthetic deterioration of skin
  • Diagnostic method for aesthetic deterioration of skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0326] The following example shows the identification of signatures including 60 metabolites and 8 microbes in skin samples from individuals exposed to chronic pollution based on the detection of high levels of pollutants in their hair samples significantly adjusted.

[0327] Methods and Results

[0328] Identification of "contaminated" and "uncontaminated" groups

[0329] Two groups of individuals, hereinafter referred to as group 1 (GP1) and group 2 (GP2), were derived from a comprehensive unsupervised multivariate analysis of PAH (polycyclic aromatic hydrocarbons) data blocks, metabolites and bacterial microbiome.

[0330] Skin samples from 42 women (GP1) exposed to high levels of pollution This was compared with 45 women (GP2) exposed to relatively low levels of pollution. Both groups of women were in good health and aged 25 to 45 years. In Group 1 (GP1), 30 / 42 women had lived in polluted cities in China for at least 15 years. 42 / 45 women in group 2 (GP2) had lived...

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PUM

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Abstract

The present invention relates to a method for diagnosing aesthetic deterioration of the skin of a subject, in particular an aesthetic deterioration associated with contamination, comprising the steps of (a) determining the level of at least one marker in a sample of the skin of the subject, the marker is selected from the group consisting of (i) a bacterium of the species Propionibacterium acnes, a bacterium of the family Micrococcus, a bacterium of the genus Brevibacterium, a bacterium of the genus Brevibacterium, a bacterium of the target Burkholderia, a bacterium of the genus Parococcus, a bacterium of the family Rhodobacter and a bacterium of the genus Fusiform, and (ii) metabolites of these bacteria, the compound is selected from the group consisting of 3-hydroxy-3-methylglutaric acid, 3-methylglutaric acid / 2-methylglutaric acid, 4-guanidinobutyric acid, 4-imidazoleacetic acid, 5-oxoproline, aconitic acid, adipic acid, alanine, alpha-ketoglutaric acid, arabinoic acid / xylonic acid, azelaic acid, beta-citrylglutamic acid, choline, cis-urocanic acid, citraconic acid / pentenedioic acid, fructose, fumaric acid, and the like. The amino acid composition is prepared from gamma-glutamyl alanine, gamma-glutamyl glutamine, gamma-glutamyl glycine, gamma-glutamyl isoleucine, gamma-glutamyl leucine, gamma-glutamyl serine, gamma-glutamyl threonine, gamma-glutamyl tryptophan, gamma-glutamyl valine, glutaric acid, glyceric acid, glycerol-3-phosphoric acid, glycine, isovaleryl glycine and kynurenine. The preparation method comprises the following steps: preparing lactic acid, linoleoyl ethanolamide, malic acid, maleic acid, malonic acid, maltose, methionine sulfoxide, methylsuccinic acid, N-acetyl alanine, N-acetyl arginine, N-acetyl aspartic acid, N-acetyl glycine, N-acetyl histidine, N-acetyl phenylalanine, N-acetyl threonine, N-acetyl valine, oleamide, ornithine, palmitamide, pimelic acid and proline; the composition is prepared from the following raw materials: salicylic acid, sebacic acid, serine, suberic acid, succinic acid, undecanedioic acid and S-amino-omega-caprolactam.

Description

technical field [0001] The present invention relates to the diagnosis of aesthetic degradation of the skin, especially pollution-related aesthetic degradation of the skin. Background technique [0002] Many factors can cause blemishes in the skin and its complexion. These imperfections in skin tone are the reason for more and more frequent consultations with beauty care centers or dermatologist's offices. [0003] Among the extrinsic factors that may affect the tone of the skin, mention may be made of exposure to sunlight, exposure to changes in temperature and / or humidity, exposure to pollutants or cigarette smoke. Among the intrinsic factors that affect skin tone, mention may be made of stress, fatigue, hormonal changes, dehydration of the epidermis, changes in the skin barrier function, aging or excess sebum production. [0004] These various factors can blur the complexion, making it uneven, dull, waxy or yellowish, and contribute to, or even favor, the presence of pig...

Claims

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Application Information

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IPC IPC(8): C12Q1/689G01N33/68
CPCC12Q1/689C12Q2600/142C12Q2600/112C12Q2600/158G01N33/6881G01N2800/20A61B5/442C12Q1/14G01N33/6848G01N2800/207
Inventor 娜米塔·米斯拉努赫特·恰武什奥卢C·克拉沃德
Owner LOREAL SA
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