4 results about "Azo coupling" patented technology

The invention discloses a calixarene-based azo polymer and a preparation method and application thereof, and the preparation method comprises the following steps: diazotizing 4, 4 '-(benzo [c] [1, 2, 5] thiadiazole-4, 7-diyl) diphenylamine in a solvent containing sodium nitrite and hydrochloric acid; adjusting the pH to be neutral, and adding a mixed solution of calixarene and sodium acetate for reaction to obtain the calixarene-based azo polymer. Calixarene with different cavity sizes and 4, 4 '-(benzo [c] [1, 2, 5] thiadiazole-4, 7-diyl) diphenylamine (BTD) are crosslinked through diazo coupling reaction, a series of novel calixarene-based azo polymers (MCAPs) are constructed, the MCAPs have excellent adsorption performance on iodine trianions (I3-) in water, and the MCAPs have important scientific significance and application value for promoting sustainable development of nuclear energy.

The invention belongs to the technical field of deuterated organic chemical synthesis, and particularly relates to a synthetic method of deuterated 4-bromodiphenyl-D9, which comprises the following steps: step 1, nitration reaction of deuterated bromobenzene: enabling the deuterated bromobenzene to react with mixed acid to obtain deuterated p-bromonitrobenzene-D4; step 2, reduction reaction of deuterated p-bromonitrobenzene: taking hydrazine hydrate and carbon powder as a reduction system, and reducing the deuterated p-bromonitrobenzene-D4 into deuterated p-bromoaniline; and step three, diazo coupling reaction of deuterated p-bromoaniline: carrying out diazo coupling reaction on deuterated p-bromoaniline and deuterated benzene to obtain the target product deuterated 4-bromodiphenyl-D9. The synthesis method is simple in process, high in purity and simple in post-treatment, the used raw materials are low in price and easy to obtain, the application of the deuterated biphenyl aromatic hydrocarbon as an intermediate in organic photoelectric synthesis is expanded, the problems of more byproducts, reduced deuteration rate, high cost and the like in a traditional process are solved, and the synthesis method is suitable for industrial production.

The application relates to the technical field of organic synthesis, and provides a preparation method of 4-[(2,4-diaminophenyl)azo]benzenesulfonic acid. The p-aminobenzenesulfonic acid, hydrochloric acid, sodium nitrite and a solvent are mixed, a diazotization reaction is carried out under strong acid conditions to generate a diazonium salt solution; the m-phenylenediamine, formaldehyde, sodium bisulfite and a solvent are mixed to generate 1,3-benzene di(iminomethyl sulfonic acid sodium) coupling solution; then the coupling solution is slowly added into the diazonium salt solution, and stirring is carried out at room temperature overnight; and after alkaline hydrolysis and acidification, the target product is obtained. The diazo coupling reaction is adopted to successfully synthesize a 4-[(2,4-diaminophenyl)azo]benzenesulfonic acid compound, the reagent used in the method is cheap and easy to obtain, the operation is simple, the yield is high, and the method is suitable for industrial production.

The application belongs to the technical field of biological materials, and particularly relates to a silk fibroin-loaded hydrogel liposome with transdermal delivery effect and a preparation method and application thereof. The preparation method comprises the following steps: dissolving degummed silk in a neutral salt solution to obtain a silk fibroin solution, performing dialysis filtration to obtain a silk fibroin aqueous solution; then performing a diazo coupling reaction on the silk fibroin aqueous solution to obtain an azide-functionalized silk fibroin aqueous solution; dissolving phospholipid and cholesterol in a solvent to obtain a mixed solution; adding the azide-functionalized silk fibroin aqueous solution into the mixed solution to perform ultrasonic emulsification to obtain an emulsion; sequentially performing reverse evaporation treatment on the emulsion to obtain a gelled silk fibroin-loaded liposome; and performing freeze-drying on the gelled silk fibroin-loaded liposome to obtain the silk fibroin-loaded hydrogel liposome with transdermal delivery effect.