A state of a programmable mixer is set during a calibration phase to minimize local oscillator feedthrough. During a calibration phase, inputs to the programmable mixer are set to zero, or to a known state and the local oscillator is set to a calibration frequency. Then, one of a plurality of known calibration states of the programmable mixer is entered and the local oscillator feedthrough is measured. For each of a plurality of operating states an amplified output of the programmable mixer is measured. In one operation, the state of the programmable mixer in which the programmable mixer operates during a next operation phase is the state that produces minimal local oscillator feedthrough. In another operation, operation continues until a state is found that produces a local oscillation feedthrough that meets an operating criteria and that state is used during the next operation phase. After these operations are complete, programmable mixer calibration operations are completed until the next calibration phase commences.