The invention relates to the field of healthcare products and particularly discloses a natto compound for detox beauty and a preparation method of the natto compound. The natto compound comprises, by mass, 20-40 parts of natto powder, 5-10 parts of pueraria extracts, 3-8 parts of tremella polysaccharide, 1-5 parts of konjac oligosaccharides, 8-12 parts of wolfberry powder, 5-10 parts of longan powder and 5-10 parts of jujube powder. The natto compound has the functions of clearing away heat and toxic materials, promoting digestion and relieving stasis, smoothing intestine and relieving constipation, supporting blood and invigorating kidneys, recuperating Qi and blood, improving the body immunity, decreasing lipid, caring for the skin and the like. Implementation of the natto compound has the beneficial effects that through the synergistic effect among all the components, while the functions of clearing toxic materials, facilitating feces excretion and facilitating anal exsufflation are achieved for people, the functions of preventing or relieving multiple diseases, delaying senescence, reducing chromatosis, smoothing the skin and retaining youthful looks are also achieved.