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133 results about "Hematopoietic progenitor cells" patented technology

Hematopoietic progenitor cells (HPCs) or hematopoietic stem cells (HSCs) are cells present in blood and bone marrow. HPCs are capable of forming mature blood cells, such as red blood cells (the cells that carry oxygen), platelets (the cells that help stop bleeding) and white blood cells (the cells that fight infections).

Modulation of bcl11a for treatment of hemoglobinopathies

ActiveUS20110182867A1Increasing fetal hemoglobin levelHigh expressionOrganic active ingredientsVirusesHemoglobinopathyFetal hemoglobin
The invention relates to methods and uses of modulating fetal hemoglobin expression (HbF) in a hematopoietic progenitor cells via inhibitors of BCL11A expression or activity, such as RNAi and antibodies.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE

Methods and compositions for the differentiation of stem cells

The present invention provides methods and compositions for the production of hematopoietic progenitor cells or endothelial progenitor cells from human pluripotent stem cells using a defined cell culture medium without the need to utilize feeder cells or serum. In some embodiments, differentiation is accomplished using hypoxic atmospheric conditions. The defined medium of the present invention may contain growth factors and a matrix component. The hematopoietic progenitor cells may be further differentiated into cell lineages including red blood cells, macrophages, granulocytes, and megakaryocytes. The endothelial progenitor cells may be further differentiated into endothelial cells. Also disclosed are screening assays for identification of candidate substances that affect differentiation of pluripotent stem cells into progenitor cells.
Owner:FUJIFILM CELLULAR DYNAMICS INC

Methods for manipulating phagocytosis mediated by CD47

Methods are provided to manipulate phagocytosis of cells, including hematopoietic cells, e.g. circulating hematopoietic cells, bone marrow cells, etc.; and solid tumor cells. In some embodiments of the invention the circulating cells are hematopoietic stem cells, or hematopoietic progenitor cells, particularly in a transplantation context, where protection from phagocytosis is desirable. In other embodiments the circulating cells are leukemia cells, particularly acute myeloid leukemia (AML), where increased phagocytosis is desirable.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV

Therapeutic compositions containing glutathione analogs

Pharmaceutical compositions and methods of using them. Lipid formulations of a glutathione analog and methods of manufacturing them. Their use to stimulate hematopoiesis, protect hematopoietic cells from damage caused by radiation or chemotherapy, or potentiate the stimulatory action of one or a combination of cytokines on colony formation by hematopoietic progenitor cells, protect a subject from a destructive effect of a chemotherapeutic agent or irradiation, or to potentiate the effect of a chemotherapeutic agent.
Owner:TELIK INC

Hematopoietic protection against ionizing radiation using selective cyclin-dependent kinase 4/6 inhibitors

InactiveUS20110224221A1Reducing or preventing the effects of ionizing radiation on healthy cellsHigh activityBiocideAntinoxious agentsGeneticsCyclin-dependent kinase 4
Methods for reducing or preventing the effects of ionizing radiation in healthy cells arc provided. The methods relate to the use of selective cyclin-dependent kinase (CDK) 4 / 6 inhibitors to induce transient quiescence in CDK4 / 6 dependent cells, such as hematopoietic stem cells and / or hematopoietic progenitor cells. Radioprotection can be effected in mammals by treatment with selective CDK4 / 6 inhibitor compounds either before, at the same time as, or after exposure to the ionizing radiation.
Owner:NORTH CAROLINA AT CHAPEL HILL THE UNIV OF

Assay for safety assessment of therapeutic genetic manipulations, gene therapy vectors and compounds

The invention is directed to methods of assessing the safety of therapeutic compounds and therapeutic genetic manipulations, including integrating gene therapy vectors and genome editing. In particular, the invention provides a method, wherein the oncogenic potential of therapeutic compounds and therapeutic genetic manipulations, including integrating gene therapy vectors and genome editing, is determined by determining the percentage of differentiation blocked hematopoietic progenitor cells.
Owner:ST JUDE CHILDRENS RES HOSPITAL INC

Mobilization of hematopoietic stem cells

Methods, processes, uses, and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells and / or cancer stem cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as a Cdc-42 specific inhibitor alone or in combination with one or more additional agents. Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. In particular, embodiments of the method involve specific inhibition of the Cdc42 GTPase to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject.
Owner:CHILDRENS HOSPITAL MEDICAL CENT CINCINNATI

Human mesenchymal progenitor cell

There is provided an isolated pluri-differentiated human mesenchymal progenitor cells (MPCs), a method for isolating and purifying human mesenchymal progenitor cells from Dexter-type cultures, and characterization of and uses, particularly therapeutic uses for such cells. Specifically, there is provided isolated MPCs which can be used for diagnostic purposes, to enhance the engraftment of hematopoietic progenitor cells, enhance bone marrow transplantation, or aid in the treatment or prevention of graft versus host disease.
Owner:UNIV OF SOUTH FLORIDA

Production methods for megakaryocytes and platelets

An object of the present invention is to provide a method of efficiently producing a maturated megakaryocytic cell line from hematopoietic progenitor cells. The present invention provides a method for producing megakaryocytes from hematopoietic progenitor cells, comprising(i) forcibly expressing an apoptosis suppression gene and an oncogene in hematopoietic progenitor cells and culturing the cells, and(ii) arresting forced expression of the apoptosis suppression gene and the oncogene and culturing the hematopoietic progenitor cells.
Owner:KYOTO UNIV

Modulation of BCL11A for treatment of hemoglobinopathies

ActiveUS8383604B2Organic active ingredientsVirusesHemoglobinopathyFetal hemoglobin
The invention relates to methods and uses of modulating fetal hemoglobin expression (HbF) in a hematopoietic progenitor cells via inhibitors of BCL11A expression or activity, such as RNAi and antibodies.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE

Methods for treating a patient undergoing chemotherapy

The present invention provides improved methods, kits, and pharmaceutical compositions for increasing hematopoietic cell survival and / or reducing or preventing the side effects of chemotherapy, and mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood following chemotherapy, comprising administering an effective amount angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII) AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists to a patient in need of chemotherapy.
Owner:UNIV OF SOUTHERN CALIFORNIA

Use of cd34+ hematopoietic progenitor cells for the treatment of cns disorders

InactiveUS20050163760A1Improve bioavailabilityLengthening possible duration of treatmentBiocideNervous disorderDiseaseDuration treatment
The present invention provides novel methods for delivering cells, particularly modified cells to the central nervous system (CNS). The purpose of this invention is to present a method that provides sustained delivery of a molecule to the central nervous system, thereby increasing the bioavailability of the molecule and lengthening the possible duration of treatment.
Owner:INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM)

Methods of Ex Vivo Expansion of Blood Progenitor Cells, and Generation of Composite Grafts

InactiveUS20130136722A1Sustained blood cell productionImprove survivalBiocideMicrobiological testing/measurementProgenitorCell type
This invention provides methods and compositions of hematopoietic progenitor cells and hematopoietic stem cells, particularly methods for expanding populations of these cells types from biological sources.
Owner:THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS

Methods for Manipulating Phagocytosis Mediated by CD47

Methods are provided to manipulate phagocytosis of cells, including hematopoietic cells, e.g. circulating hematopoietic cells, bone marrow cells, etc.; and solid tumor cells. In some embodiments of the invention the circulating cells are hematopoietic stem cells, or hematopoietic progenitor cells, particularly in a transplantation context, where protection from phagocytosis is desirable. In other embodiments the circulating cells are leukemia cells, particularly acute myeloid leukemia (AML), where increased phagocytosis is desirable.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV

Method for differentiating human pluripotent stem cells into natural killer cells and application

The invention relates to the field of stem cell biology, specifically to a method for differentiating human pluripotent stem cells into natural killer cells and an application. The invention disclosesa pluripotent stem cell-derived natural killer cell. The pluripotent stem cell-derived natural killer cell expresses CD56, Nkp30, Nkp44 and Nkp46, and also expresses markers CD16 and CD94 of a maturenatural killer cell. The invention also discloses a method for preparing the natural killer cell. The method comprises the following steps: S1, formation of an embryoid body; S2, differentiation of the embryoid body into hematopoietic progenitor cells; S3, differentiation of the hematopoietic progenitor cells into NK cells; and S4, maturation and expansion of the NK cells. With the differentiation method provided by the invention, the pluripotent stem cells can be rapidly, efficiently, simply and conveniently induced to be differentiated into the natural killer cells with low cost on the basis of a culture medium with definite components and an optimized cell factor combination.
Owner:安徽中盛溯源生物科技有限公司

Parathyroid hormone receptor activation and hematopoietic progenitor cell expansion

ActiveUS20060257376A1Improve scalabilityIncrease in self-renewal/numberAntibacterial agentsAntimycoticsPTHrP ReceptorIn vivo
The invention relates to methods for manipulating hematopoietic progenitor cells and related products. In one aspect the invention relates to the use of agents that activate a PTH / PTHrP receptor to enhance the growth and maintenance of hematopoietic progenitor cells in vivo and in vitro, to enhance mobilization of hematopoietic stem cells, to improve the efficiency of targeting cells to the bone marrow, and / or to modulate hematopoietic progenitor cell function.
Owner:THE GENERAL HOSPITAL CORP

Hematopoietic protection against chemotherapeutic compounds using selective cyclin-dependent kinase 4/6 inhibitors

Methods for reducing or preventing the effects of cytotoxic compounds in healthy cells are provided. The methods relate to the use of selective cyclin- dependent kinase (CDK) 4 / 6 inhibitors to induce transient quiescence in CDK4 / 6 dependent cells, such as hematopoietic stem cells and / or hematopoietic progenitor cells. Also described is a method of selecting compounds for reducing or preventing the effects of cytotoxic agents compounds in healthy cells.
Owner:THE UNIV OF NORTH CAROLINA AT CHAPEL HILL

Mobilization of hematopoietic cells

Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. In particular, embodiments of the method involve inhibition of both Rac1 and Rac2 GTPases to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject. The subject's blood can be processed and used to repopulate the destroyed lymphohematopoietic system of a recipient and may in the future be utilized to repair a variety of non-hematopoietic tissues. Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. They can also be used for increasing white blood cell survival and for chemotherapy.
Owner:CHILDRENS HOSPITAL MEDICAL CENT CINCINNATI

Methods for genetic modification of hematopoietic progenitor cells and uses of the modified cells

Described are compositions and methods relating to gene therapy, particularly as applied to hematopoietic progenitor (HP) cells, to transduced cells and methods of obtaining them, and to methods of using them to provide prolonged engraftment of modified hematopoietic cells in human subjects. The invention particularly relates to ex vivo gene therapy of HP cells for treatment or prevention of HIV infection.
Owner:JOHNSON & JOHNSON RES PTY LTD

Therapeutic compositions containing glutathione analogs

Pharmaceutical compositions and methods of using them. Lipid formulations of a glutathione analog and methods of manufacturing them. Their use to stimulate hematopoiesis, protect hematopoietic cells from damage caused by radiation or chemotherapy, or potentiate the stimulatory action of one or a combination of cytokines on colony formation by hematopoietic progenitor cells, protect a subject from a destructive effect of a chemotherapeutic agent or irradiation, or to potentiate the effect of a chemotherapeutic agent.
Owner:TELIK INC

Mobilization of hematopoietic stem cells

ActiveUS20130202553A1Effective levelingGrowing populationBiocidePeptide/protein ingredientsHematopoietic Stem Cell MobilizationSurgery
Methods, processes, uses, and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells and / or cancer stem cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as a Cdc-42 specific inhibitor alone or in combination with one or more additional agents. Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. In particular, embodiments of the method involve specific inhibition of the Cdc42 GTPase to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject.
Owner:CHILDRENS HOSPITAL MEDICAL CENT CINCINNATI

Uses of IL-12 in hematopoiesis

ActiveUS20050136034A1Reduces hematopoietic toxicityFacilitating eradicationOrganic active ingredientsPeptide/protein ingredientsWhite blood cellIn vivo
Embodiments of the present invention are directed to uses of Interleukin-12 (IL-12) in enhancing or stimulating hematopoiesis to yield hematopoietic recovery in a mammal in need. Particular embodiments of the invention are directed to uses of IL-12 as an adjuvant therapy to alleviate the hematopoietic toxicities associated with one or more treatment regimens used to combat a disease state. Other embodiments include uses of IL-12 to ameliorate various hematopoietic deficiencies. Still other embodiments are directed to uses of IL-12 for in-vivo proliferation of hematopoietic repopulating cell, hematopoietic progenitor cells and hematopoietic stem cells. Other disclosed embodiments are directed to uses of Il-12 for bone marrow preservation or recovery.
Owner:UNIV OF SOUTHERN CALIFORNIA

Methods and compositions for the differentiation of stem cells

The present invention provides methods and compositions for the production of hematopoietic progenitor cells or endothelial progenitor cells from human pluripotent stem cells using a defined cell culture medium without the need to utilize feeder cells or serum. In some embodiments, differentiation is accomplished using hypoxic atmospheric conditions. The defined medium of the present invention may contain growth factors and a matrix component. The hematopoietic progenitor cells may be further differentiated into cell lineages including red blood cells, macrophages, granulocytes, and megakaryocytes. The endothelial progenitor cells may be further differentiated into endothelial cells. Also disclosed are screening assays for identification of candidate substances that affect differentiation of pluripotent stem cells into progenitor cells.
Owner:FUJIFILM CELLULAR DYNAMICS INC

Medium composition and method for producing red blood cells using same

InactiveUS20160060601A1Efficient productionShort timeCell culture supports/coatingBlood/immune system cellsHematopoietic progenitor cell differentiationRed Cell
The present invention provides a method of producing erythrocytes, including efficiently differentiating hematopoietic stem cells and / or a hematopoietic progenitor cells into erythrocytes by using a medium composition having an effect of homogeneously dispersing the hematopoietic stem cells and / or the hematopoietic progenitor cells and maintaining a floating state.
Owner:NISSAN CHEM IND LTD

Mobilization of hematopoietic cells

Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. In particular, embodiments of the method involve inhibition of both Rac1 and Rac2 GTPases to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject. The subject's blood can be processed and used to repopulate the destroyed lymphohematopoietic system of a recipient and may in the future be utilized to repair a variety of non-hematopoietic tissues. Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. They can also be used for increasing white blood cell survival and for chemotherapy.
Owner:CHILDRENS HOSPITAL MEDICAL CENT CINCINNATI

Method for increasing hematopoietic progenitor cells by stem cell factor

Novel stem cell factors, oligonucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders involving blood cells are also disclosed.
Owner:BIOVITRUM AB (PUBL)

Method for inducing and differentiating human multipotent stem cells into aged blood cells

The invention belongs to the field of induced differentiation of blood cells, and provides a method for inducing and differentiating human multipotent stem cells into aged blood cells. The method comprises the following steps of A, inducing and differentiating the human multipotent stem cells into hematopoietic progenitor cells CD31 and CD34; B, inducing and differentiating the hematopoietic progenitor cells CD31 and CD34 into human aged cells. The method has the advantages that by adopting the two-step inducing type of single-layer cell culture and suspension cell culture, the inducing procedure is simplified, the inducting time is shortened, the operation is simple, the efficiency is high, and the stability is realized; by adopting the inducing and differentiating system without feed layer cells, the induced blood cell has biological safety guarantee, the requirements of clinical conversion and clinical experiment can be met, and the medical conversion value is high.
Owner:NORTHWEST A & F UNIV
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