The present application relates to a preparation method of high-efficiency stable mulberry root extract containing
oxyresveratrol and its application in relieving
skin itching, and belongs to the technical field of
cosmetics. The preparation method of the mulberry root extract containing
oxyresveratrol comprises the following steps:
drying and crushing the root of a mulberry tree, adding the crushed root into an
aqueous solution of a eutectic
solvent to perform ultrasonic extraction, centrifuging the product to obtain the mulberry root extract containing
oxyresveratrol. The present application is based on a green
solvent system composed of
betaine and 1,3-
propanediol /
ethyl lactate, and combines with mild ultrasonic conditions to realize the efficient extraction of oxyresveratrol from the mulberry root, so that the extraction rate is improved and the risk of high-temperature oxidation is avoided. Moreover, the obtained extract can not only long-acting inhibit the itch
receptor MRGPX1, but also is suitable for
sensitive skin due to the removal of irritating components, and has high efficiency and
biocompatibility, thereby breaking through the environmental
pollution and technical
bottleneck of the traditional method and having a wide market application prospect.