The invention relates to a preparation method of an efficient and stable mulberry root extract containing
oxyresveratrol and application of the mulberry root extract in relieving
skin itching, and belongs to the technical field of
cosmetics. The preparation method of the mulberry root extract containing
oxyresveratrol comprises the following steps:
drying and crushing mulberry roots and stems, adding the crushed mulberry roots and stems into an
aqueous solution of a deep-eutectic
solvent, carrying out ultrasonic extraction, collecting a product, centrifuging, and taking supernate, so as to obtain the mulberry root extract containing
oxyresveratrol. According to the method, on the basis of a green
solvent system composed of
betaine and 1, 3-
propylene glycol /
ethyl lactate and in combination with mild ultrasonic conditions, oxyresveratrol is efficiently extracted from mulberry roots, so that the extraction rate is increased, and the risk of high-temperature oxidation is avoided. And the obtained extract not only can inhibit the itch
receptor MRGPX1 for a long time, but also is suitable for
sensitive skin due to removal of irritant components, has high efficiency and
biocompatibility, breaks through environmental
pollution and technical bottlenecks of a traditional method, and has a wide market application prospect.