The present invention provides a CRF2
agonist having desirable
efficacy, pharmacokinetic properties (e.g., improved half-life), and / or physicochemical properties (e.g., improved stability and / or
solubility). [Solution] Provided are compounds that are agonists of corticotropin-releasing factor
receptor 2 (CRF2), which are peptides containing a specific
amino acid sequence, or pharmaceutically acceptable salts thereof, and the use thereof in the treatment, particularly in the treatment or prevention of cardiovascular
disease,
obesity and diabetes.