The invention discloses an anti-collision device for a laser-guided vehicle and an implementation method. The device includes a vehicle body. The bottom of the vehicle body is fixedly connected with acentral moving part, the front and rear sides of the central moving part are provided with a front moving part and a rear moving part respectively, the rear driving part is internally provided with adrive mechanism and a control mechanism, the bottom of the side face of the central moving part is provided with an arch groove, the side face of the arch groove is connected with the front moving part through a cushion spring, the tops of the front moving part and the rear moving part are provided with a front sliding rail and a rear sliding rail, and the front and rear sides of the bottom surface of the vehicle body are provided with a front guide slider and a rear guide slider. The device prevents vehicle collision through mechanical buffering and intelligent obstacle avoidance, the anti-collision effect is better, the vehicle does not need to work, and the carrying efficiency is easily improved. Meanwhile, the walking route of one vehicle can be changed when the front vehicle collidesor avoids obstacles, and the handling work of other vehicles is not affected.