49results about How to "Inhibiting consequence" patented technology

A bone member fastener for closing a craniotomy includes a cap and a base interconnected by a narrow cylindrical collar. The cap has an externally threaded stud that screws into an internally threaded bore of the collar, thereby allowing the cap and base to be brought into clamping engagement against the internal and external faces of a bone plate and surrounding bone. In a particularly disclosed embodiment, the base of the fastener is placed below a craniotomy hole with the collar projecting into the hole, and the stud of the cap is screwed into the bore of the base from above the hole to clamp a bone flap against the surrounding cranium. This device provides a method of quickly and securely replacing a bone cover into a craniotomy. The distance between the cap and base can be selected by how far the threaded stud of the cap is advanced into the internally threaded collar. The fastener is therefore adaptable for use in several regions of the skull having various thicknesses. An insertion tool with a long handle permits safe and convenient placement of the base between the brain and the internal face of the bone plate. Some disclosed embodiments of the fastener have a cap and base that conform to the curved surface of the skull, for example by having an arcuate shape or flexible members that conform to the curvature of the bone plate and surrounding cranial bone as the fastener is tightened.

Systems and methods are provided for applying electrical stimulation and / or introducing one or more stimulating drugs to the brain to treat or prevent aphasia, including through use of at least one system control unit (SCU) for controlling electrical pulses delivered via electrodes implanted in the brain and / or for producing drug infusion pulses to targeted areas in the brain.

Various embodiments are disclosed of a failure detection system for a solid-state data storage system that can experience difficulties, such as system failure or loss of data integrity, when it runs out of spare storage locations. Spare storage locations can be used by a solid-state data storage system to replace storage locations that have become defective. In one embodiment, a count is kept of the available spare storage locations in a system, or sub-system, and when the amount of available spare locations drops to a threshold value, an action can be taken to avoid the consequences of an impending failure. In other embodiments, the available spare storage locations are monitored by keeping track of the percentage of initially available spare locations still remaining, by keeping track of the rate of new spare locations being used, or by other techniques. In various embodiments, the early failure detection system responds to detection of a possible impending failure by taking one or more of a variety of actions, including, for example, sending an alert notification, enabling additional storage capacity, copying portions of the data stored in the system to other secure storage locations, shutting the system down, and taking no action.

A bone member fastener for closing a craniotomy includes a cap and a base interconnected by a narrow cylindrical collar. The cap has an externally threaded stud that screws into an internally threaded bore of the collar, thereby allowing the cap and base to be brought into clamping engagement against the internal and external faces of a bone plate and surrounding bone. In a particularly disclosed embodiment, the base of the fastener is placed below a craniotomy hole with the collar projecting into the hole, and the stud of the cap is screwed into the bore of the base from above the hole to clamp a bone flap against the surrounding cranium. This device provides a method of quickly and securely replacing a bone cover into a craniotomy. The distance between the cap and base can be selected by how far the threaded stud of the cap is advanced into the internally threaded collar. The fastener is therefore adaptable for use in several regions of the skull having various thicknesses. An insertion tool with a long handle permits safe and convenient placement of the base between the brain and the internal face of the bone plate. Some disclosed embodiments of the fastener have a cap and base that conform to the curved surface of the skull, for example by having an arcuate shape or flexible members that conform to the curvature of the bone plate and surrounding cranial bone as the fastener is tightened.

Compounds, compositions, and methods are provided for treatment of disorders related to mitochondrial dysfunction. The methods comprise administering to a mammal a composition containing pyrimidine nucleotide precursors in amounts sufficient to treat symptoms resulting from mitochondrial respiratory chain deficiencies.

A fault-tolerant node for synchronous heterogeneous database replication and a method for performing a synchronous heterogenous database replication at such a node are provided. A processor executes a computer program to generate a series of database transactions to be carried out at the fault-tolerant node. The fault-tolerant node comprises at least two relational database management systems, each of which are different relational database management system products, each implementing snapshot isolation between concurrent transactions. Each system comprises a database and a database management component. For each database transaction, operation instructions are provided concurrently to each of the systems to carry out operations on their respective databases and to provide respective responses. The responses generated by the systems either comprise an operation result or an exception. Only one of the systems is configured with a NOWAIT exception function enabled, which returns an exception when it is detected that two or more concurrent transactions are attempting to modify the same data item. The other systems are configured with the NOWAIT exception function disabled. The fault-tolerant node detects that two or more concurrent transactions are attempting to modify the same data item, and ensures that all systems apply the same order of modification of the data item by the concurrent transactions.

In a duplex chat conversational trading system, trader terminals monitor for new incoming messages from the time a trader starts to input a new message to the time it is sent. If an incoming message is detected, sending of the message is inhibited and the trader is alerted to the new incoming message whereupon he can confirm his message, modify it or resend it. Messages are exchanged via a chat server which assigns a unique reference number to each message. Where a message received at the server is sent in reply to an earlier message it carries the reference of the earlier message. The server compares this reference to the most recent reference it has logged and notifies the parties of a crossover if the references are not the same.

Systems and methods are provided for applying electrical stimulation and / or introducing one or more stimulating drugs to the brain to treat or prevent aphasia, including through use of at least one system control unit (SCU) for controlling electrical pulses delivered via electrodes implanted in the brain and / or for producing drug infusion pulses to targeted areas in the brain.

The present invention relates to a policy resolution method and system, access network and terminal device for enabling modular network-assisted policy resolution, wherein the policy resolution is divided into separate stages each handling specific types of trigger events and performing specific types of policy actions. The separate stages are processed in a chronological order during a policy resolution round, and trigger events which occur during a policy resolution round are frozen until the start of the next policy resolution round. Thereby, modular policy resolution with reduced delays and oscillations can be achieved. Moreover, policy processing can be divided into a policy decision point functions in the network and a policy enforcement point function in the network or terminal device, so that terminal resources used for policy resolution can be saved.

A method and apparatus for transferring AC electrical power to a load from a first power source to a second power source provides for a time delay in the transfer to avoid problems associated with differences in the phases between the power sources. The phase of the voltage waveform from each power source is sensed continuously, and the phase difference is known at all times, so that it can be used when the transfer is necessary. The method and apparatus monitors the voltage from the first power source, and initiates the transfer from the first power source to the second power source in response to an unacceptable condition from the first power source. The second power source is connected only after waiting for a period of time corresponding to the appropriate time delay.

The present invention is related to Nox4 inhibitors, pharmaceutical composition thereof and to their use for the treatment and / or prevention of osteoporosis or an osteoclastogenesis dysfunction, in particular osteoporotic and pre-osteoporotic osteoclastogenesis dysfunction.

A method and apparatus for transferring AC electrical power to a load from a first power source to a second power source provides for a time delay in the transfer to avoid problems associated with differences in the phases between the power sources. The phase of the voltage waveform from each power source is sensed continuously, and the phase difference is known at all times, so that it can be used when the transfer is necessary. The method and apparatus monitors the voltage from the first power source, and initiates the transfer from the first power source to the second power source in response to an unacceptable condition from the first power source. The second power source is connected only after waiting for a period of time corresponding to the appropriate time delay. By avoiding instantaneous transfers and providing for a delay in the switching to a secondary power source, the present invention avoids the problems associated with transformer saturation, and the resulting draw of a large amount of current from the power source that can cause upstream circuit breakers to trip open, and uninterruptible power systems and engine generators to malfunction.

A respiratory anesthetic aggregate devised for coupling to a breathing apparatus has an anesthetic gasifier unit that has a breathing gas input port connected to a first point in an inspiratory patient gas delivery path of a breathing apparatus, and a fresh gas output port connected to a second point in the patient gas delivery path downstream the first point. The inspiratory patient gas delivery path is connected via a mainstream connection between the first and second point. Thereby the anesthetic gasifier unit is connected in a sidestream configuration to the patient gas delivery path for adding the gasified anesthetic agent in a desired concentration to the patient gas delivery path at the second point. The When aggregate is coupled to a breathing apparatus, a substantially volume neutral delivery of anesthetic agent is provided a to the breathing apparatus.

A network defense system can include a sensor alert ingestion framework adapted to monitor network activity and alert detected or suspected anomalies. A network analyzer may be coupled to the sensor alert ingestion framework to analyze the anomalies. A course of action (CoA) simulator may be coupled to the network analyzer adapted to generate a list of decision including courses of action to address the anomalies. There may be a training and feedback unit coupled to the CoA simulator to train the system to improve responses in addressing future anomalies.

A system for warning a party provided with a terminal comprises databases of profile information of the party, environment information of a geographical location, and location information of the terminal. The system is adapted to, based on location information of the terminal, to check whether the terminal locates within the geographical location, and if yes, to analyse profile information of the party so that if profile information comprises a parameter which matches with a corresponding parameter of environment information of a geographical location, a warning message is sent to the terminal in order to warn the party.

The vehicle impact attenuator comprises at least two impact absorber bodies for transforming impact energy which acts along a central impact axis, into deformation energy. The bodies are arranged in pairs, and the bodies of each pair are located on either side of a central axis of the device, and are mechanically interconnected in such a way that the deformation of one of these bodies due to a crashing vehicle results in a deformation also of the other absorber body, induced by said mechanical interconnection.

Steering control system for a land vehicle with at least four steered wheels (1AvG, 1AvD, 1ArG, 1ArD), the system comprising one actuator per steered wheel (3AvG, 3AvD, 3ArG, 3ArD). The system comprises a control member (2) available to a driver and delivering a demanded steering angle (θ), a steering control unit (4) which, by way of input variable, uses at least the said demanded steering angel (θ) to determine a steering control angle for operating the said actuator, and means (5) for detecting a lock-up of one of the steered-wheel actuators, which are capable of delivering an alarm signal identifying an actuator that has locked up. The steering control unit has at least one normal mode and at least one degraded mode in the event of an actuator becoming locked up, the degraded mode calculating the steering control angle (αpi) of the non-locked wheels by imposing a first degraded-mode strategy whereby the instantaneous center of rotation (CIR) of the vehicle lies more or less on the straight line perpendicular to the plane of the locked wheel and passing through the center of the ground-contact area of the locked wheel, in a position that is dependent on the demanded steering angle (θ).

A safety system for a tire blowout in a vehicle is disclosed. The system can be activated when a tire blowout occurs. The system comprises of pellets arranged on the outer surface of the rim. The friction between the pavement, the rim, and the tire increases and heats the pellets when a tire blowout occurs. The pellets inflate inside the rim and cover a bigger space as soon as it heats up. The bigger sized pellets on the outer surface of the rim after blowout, acts like a secondary tire and avoids consequences of a tire blowout. The system can also comprise of a rim airbag which explodes as soon as the tire blows out and creates a pseudo tire. The safety system reduces the initial shock of the blowout and prevents losing control of the vehicle, Also, the system creates enough resistance to keep the vehicle in control and bring it to a safe speed. Note also that the “pseudo-tire” may be driven “X” amount of miles (under a certain speed), so the driver may drive to the nearest appropriate area.

Compounds, compositions, and methods are provided for treatment of disorders related to mitochondrial dysfunction. The methods comprise administering to a mammal a composition containing pyrimidine nucleotide precursors in amounts sufficient to treat symptoms resulting from mitochondrial respiratory chain deficiencies.

An active medical device that is able to detect and treat ventiliatory activity disorders during sleep. This device measures the patient's respiratory activity, delivers a signal of the ventiliatory activity of the patient, analyzes the ventiliatory activity signal, and detects the occurrence of hypopneas. The analysis includes calculating at regular intervals a sliding average of the signal of ventiliatory activity, comparing the values of the successive sliding averages thus calculated, and detecting an occurrence of an hypopnea when, for two successive sliding averages, the difference between the averages crosses a predetermined threshold of comparison. When the device is one that also delivers cardiac stimulation pulses, it is advantageously envisaged to modify an operating parameter, in particular the stimulation rate based on the detected hypopnea, to treat the hypopnea.

A data network in which at least one switch is provided with the facility for estimating current network demands using a polygonal approximation to scaled cumulant generating function. The approximation is iteratively refined in accordance with sampled data passing through the switch. The switch estimates the demand associated with a new data processing request as it is received by the switch and decides whether to accept the request based on available resources.

A method of improving DNA repair and reducing DNA damage and for reducing mutation frequency in skin for the purpose of reducing consequences of exposure to solar or ultraviolet radiation is disclosed. The methods comprise administering to the skin a composition containing deoxyribonucleosides in concentrations sufficient to enhance DNA repair or reduce mutation frequency in a vehicle capable of delivering effective amounts of deoxyribonucleosides to the necessary skin cells.

Fuel exhaust (109) of a primary fuel cell stack (11) flows into an auxiliary fuel cell stack (12) which powers a DC storage (82) feeding a bi-directional DC / AC converter (86) that is switchable (89) to auxiliary equipment (90, 91) (such as pumps) to a main power bus (54) feeding a main load (55). Fresh fuel (97) is provided (98, 105) to the primary stack for 90% fuel utilization, with over 99% overall power plant fuel utilization. The auxiliary equipment (90, 91) may be powered by the bus (54).

Various embodiments are disclosed of a failure detection system for a solid-state data storage system that can experience difficulties, such as system failure or loss of data integrity, when it runs out of spare storage locations. Spare storage locations can be used by a solid-state data storage system to replace storage locations that have become defective. In one embodiment, a count is kept of the available spare storage locations in a system, or sub-system, and when the amount of available spare locations drops to a threshold value, an action can be taken to avoid the consequences of an impending failure. In other embodiments, the available spare storage locations are monitored by keeping track of the percentage of initially available spare locations still remaining, by keeping track of the rate of new spare locations being used, or by other techniques. In various embodiments, the early failure detection system responds to detection of a possible impending failure by taking one or more of a variety of actions, including, for example, sending an alert notification, enabling additional storage capacity, copying portions of the data stored in the system to other secure storage locations, shutting the system down, and taking no action.

A method of improving DNA repair and reducing DNA damage and for reducing mutation frequency in skin for the purpose of reducing consequences of exposure to solar or ultraviolet radiation is disclosed. The methods comprise administering to the skin a composition containing deoxyribonucleosides in concentrations sufficient to enhance DNA repair or reduce mutation frequency in a vehicle capable of delivering effective amounts of deoxyribonucleosides to the necessary skin cells.

A method of treating suffering from a CNS disorder, comprising administering a reduced folate, or a derivative, prodrug, active metabolite, stereoisomer, polymorph, analogue, or pharmaceutically acceptable salt thereof, to a human suffering from a neurobehavioral CNS disorder in which the patient exhibits a folate deficiency, wherein the amount of reduced folate is therapeutically effective to improve at least one core symptom of the CNS disorder, is disclosed.