The invention provides a cash register based on a tablet personal computer. The cash register comprises the tablet personal computer, a base, a panel and a tablet personal computer adaptive device. The base is a box with the upper end open, the panel is arranged at the upper port of the base in the manner that the panel is movably connected with one side of the upper port of the base, a containing space is formed by the panel and an inner cavity of the base, the tablet personal computer adaptive device is fixed to the panel and provided with an adaptive space consistent with the tablet personal computer in shape, the tablet personal computer is fixedly arranged in the adaptive space, and the tablet personal computer has the cash registering function. The containing space of the cash register is used for containing coins, sundries, portable power sources and power adapters, and articles can be conveniently stored. Thus, the external portion can only be provided with one external wire of a power line, the appearance is simple and decent, the integration degree is high, the size is small, the structure is simple, and cost is low.