Nanometer composite material and preparation method and application thereof

A technology of nanocomposite materials and mixed solutions, which can be used in botany equipment and methods, applications, chemicals for biological control, etc., and can solve the problems of high normal cell toxicity, rare earth complex solubility and poor thermal stability, etc. , to achieve broad-spectrum antibacterial and bactericidal properties, mild conditions, and low environmental pollution

Inactive Publication Date: 2013-02-13
JIANGSU UNIV
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Problems solved by technology

[0003] Early studies have proved that rare earths have biological effects such as antibacterial, anti-inflammatory, anticoagulant, and antitumor. The application research of rare earths in the fields of biomedicine has attracted people's attention. In recent years, a series of studies on the biological activity of rare earth complexes have shown that, Due to the synergistic effect between rare earths and ligands, the thermal stability, antibacterial, antitumor and other biological activities of rare earth complexes are significantly improved compared with rare earths, but the dissolution dispersibility and thermal stability of rare earth complexes are poor. The toxicity of normal cells is relatively high, so how to further improve the dissolution and dispersibility, biological activity, and thermal stability of rare earth complexes, while reducing their toxicity to normal cells is a problem that must be solved
[0004] The surface of graphene oxide has a large number of active hydrophilic functional groups such as carboxyl groups, hydroxyl groups, and epoxy bonds, which are relatively easy to disperse in aqueous solutions and other solvents. In addition, graphene oxide also has the advantages of low cytotoxicity and good biocompatibility. Wang Xiaodan et al [Functional Materials, 2011, 1 (42), 104] reported grafting rare earth lanthanum ions onto carboxylated graphene oxide sheets, and investigated the anticoagulant function of the composite material. As far as ions are concerned, they have better biological activity. Driven by the charge force, the rare earth complexes can be effectively assembled on graphene oxide sheets with large specific surface area, good dispersion solubility and low cytotoxicity, which can not only effectively regulate The structure of each component can effectively improve the dispersion solubility of rare earth complex antibacterial materials, and the obtained composite materials will have better biological activity. At present, graphene oxide / rare earth ternary complex nanocomposites and their preparation and antibacterial Activity not reported

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  • Nanometer composite material and preparation method and application thereof
  • Nanometer composite material and preparation method and application thereof
  • Nanometer composite material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Take 50 mg of graphite oxide, ultrasonically disperse it in 50 mL of aqueous solution for 5 hours, add 20 mL of 0.25 mol / L lanthanum chloride aqueous solution under the condition of stirring, after the dropwise addition, the mixture continues to stir for 1 hour and then stands overnight Obtain mixed solution A, after mixing the 8-hydroxyquinoline ethanol solution of 20 mL 0.5 mol / L and the sodium salicylate aqueous solution of 20 mL 0.25 mol / L, join in graphene oxide-lanthanum chloride mixed solution A to obtain mixed Solution B, mixed solution B continued to stir for 30 minutes, adjusted the pH value of the mixture to 6.8 with 3 mol / L sodium hydroxide solution, the mixed solution appeared turbid, continued to stir for 2 hours, and the obtained product was left to age After suction filtration, the obtained powder was repeatedly washed and filtered with deionized water and absolute ethanol, and then vacuum-dried.

[0027] figure 1 It is a scanning electron micrograph of...

Embodiment 2-72

[0029] The following examples differ from Example 1 in that the quality of graphite oxide used, the type of rare earth chloride and the type of ligand 1 are different, as shown in Table 1, and the rest are the same as those described in Example 1.

[0030] Table 1

[0031]

[0032] Examples 10-16 are similar to Example 1, the only difference is that the types of rare earth chlorides used are cerium chloride, praseodymium chloride, neodymium chloride, samarium chloride, europium chloride, erbium chloride and yttrium chloride.

[0033] Examples 17-23 are similar to Example 2, the only difference is that the types of rare earth chlorides used are cerium chloride, praseodymium chloride, neodymium chloride, samarium chloride, europium chloride, erbium chloride and yttrium chloride.

[0034] Examples 24-30 are similar to Example 3, the only difference is that the types of rare earth chlorides used are cerium chloride, praseodymium chloride, neodymium chloride, samarium chloride...

Embodiment 73

[0042] The graphene oxide / rare earth ternary complex nanocomposites prepared in Examples 1-72 were respectively mixed with Escherichia coli, Staphylococcus aureus, Bacillus pumilus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa Bacteria and Salmonella typhi were co-cultured, and plate method, minimum inhibitory concentration and minimum bactericidal concentration tests were carried out. The test methods were in accordance with 2.1.8.2 "Bacteriostatic ring test" and 2.1.8.4 "Disinfection Technical Specifications" of the Ministry of Health of the People's Republic of China. The minimum inhibitory concentration determination experiment (nutrient broth dilution method)" was operated, and the strains used were provided by the School of Pharmacy, Jiangsu University. Table 2 is the results of the plate method bacteriostatic zone test of some examples of prepared graphene oxide / rare earth ternary complex nanocomposites using different rare earth ions as raw mater...

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Abstract

The invention discloses a nanometer composite material and a preparation method and the application thereof and belongs to the field of nanometer composite materials and environment protection. The nanometer composite material is formed by effectively assembling in-situ formed rare earth ternary complex and graphene oxide. The nanometer composite material includes placing the graphene oxide in deionized water for ultrasonic dispersion, adding rare earth chloride, stirring the mixture to form a mixed solution, adding two ligand solutions which are evenly mixed, adjusting pH of the solution through a sodium hydroxide solution to 6.5-6.8, continuing stirring the mixture of the solutions after the solutions are turbid to conduct aging and conducting product suction filtration, washing and vacuum drying to obtain a composite material. The material and the method have the advantages of simple operation process, low cost, good composite material dissolution dispersibility, similar sandwich structure, good bacteriostat and bactericidal activity and the like.

Description

technical field [0001] The invention relates to a graphene oxide / rare earth ternary complex nanocomposite material and its preparation method and application. The nanocomposite material is formed by charge-driven self-assembly in a solution system by a precipitation method, and belongs to composite materials, biomedical materials and environmental protection field of materials technology. Background technique [0002] Bacteria and malignant tumors seriously affect human health and threaten human life. The development of new functional materials with excellent antibacterial activity has always been a major topic of concern to scientists. By developing environmentally friendly, efficient, and low-toxic bioactive materials to inhibit And killing harmful bacteria is an important aspect of improving human's healthy living standard and quality of life. [0003] Early studies have proved that rare earths have biological effects such as antibacterial, anti-inflammatory, anticoagula...

Claims

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Application Information

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IPC IPC(8): A01N55/02A01P1/00
Inventor 杨小飞秦洁玲崔海英王景磊李扬王文兵
Owner JIANGSU UNIV
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