Siliceous nanoparticle drug carrier, diagnostic and therapeutic preparation thereof and preparation method

Abstract

The invention discloses a siliceous nanoparticle drug carrier, a diagnostic therapeutic preparation thereof and a preparation method. The carrier is a vesicle having a lipid bilayer structure formed by doping hydration and self-assembly of a fluorescent amphiphilic molecule and a silicon-containing composite liposome, wherein the fluorescent amphiphilic molecule is a compound taking a glycerol skeleton structure as a core and formed by a bonded hydrophobic long chain and a fluorescent group; the silicon-containing composite liposome is composed of a silicon-containing inorganic precursor, a hydrophobic lipid chain, and a linking group coupling the silicon-containing inorganic precursor and the hydrophobic lipid chain, and the silicon-containing inorganic precursor of the silicon-containingcomposite liposome is hydrolyzed and then hydrolysis products are condensed to form an inorganic silicate network structure distributed on the surface of the vesicle. The diagnostic and therapeutic preparation prepared by using the carrier to load a drug has high stability, combines two drug controlled release mechanisms, that is pH and photothermal response, and enhances the stability of the fluorescent group. Through combination of chemotherapy and photothermal therapy, the recurrence rate of tumors is effectively reduced.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and specifically relates to a siliceous nanoparticle drug carrier, a siliceous nano-targeted diagnosis and treatment preparation with high stability and drug controlled release function, and a preparation method thereof. Background technique [0002] The use of nanoparticle platforms for diagnosis and treatment is one of the important means of cancer treatment. Among them, liposomes are widely used. Liposome means that when phospholipids are dispersed in water, multilayered vesicles can be formed by electron microscope observation, and each layer is a lipid bilayer, and the center of the vesicle and each layer are separated by water to form a closed vesicle Bubble. It can be composed of natural or synthetic lipids. These molecules are composed of a hydrophilic head and a lipophilic tail. The thickness of the membrane wall is generally 5-7nm. Since the chemical components of cell membranes a...

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Problems solved by technology

Since the development of nano-photothermal materials, organic dyes have attracted widespread attention for their extremely low biological toxicity and good photothermal conversion efficiency. At present, more research hotspots are also on organic dyes. However, organic dyes are in the near-infrared Photobleaching is prone to occur after multiple times of light irradiation, and the photoconversion efficiency of the dye is significantly reduced, which is not conducive to reuse, and it is difficult for a single organic dye substance to enter the body to reach the site that needs to be treated stably. Therefore, it is constructed by assembling into nanoparticles. The nano-platform system integrates photothermal therapy and diagnosis and treatment. These photothermal nano-therapeutic agents have good photothermal conversion efficiency, and can realize multifunctional applications through surface modification or bonding with other materials, which have been demonstrated in animal experiments. Excellent curative effect, worthy of people to continue to explore, has great prospects

[0004] For the treatment of tumors, simple photothermal therapy is likely to lead to recurrence, and it is difficult to inhibit tumor metastasis, while simple chemotherapy cannot achieve a controlled release effect, and has high toxicity to non-tumor tissues and organs

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