The invention discloses multifunctional health-care medicinal wine, which is prepared by soaking the following traditional Chinese medicinal materials in Baijiu: radix angelicae pubescentis, processedmyrrh, processed frankincense, rhizoma cibotii, processed radix aconiti kusnezoffii, herba lycopodii, rhizoma curculiginis, radix cyathulae, fried cortex eucommiae, radix astragali, peach kernel, flos carthami, radix angelicae sinensis, bombyx batryticatus, fructus chaenomelis, radix ginseng, fructus mume, radix platycodonis, rhizoma gastrodiae, radix notoginseng, lucid ganoderma, fruit of Chinese wolfberry, Chinese mesona herb, rhizoma smilacis glabrae, radix glycyrrhizae, radix cynoglossi amabilis, cordyceps militaris, radix rehmanniae preparata and the like. The multifunctional health-caremedicinal wine, which is prepared from rare medicinal materials in combination with a conventional process, is convenient to use, is capable of strengthening physique and is non-dependent; the medicinal wine is applicable to various aching muscles sprains of bones and muscles in whole body and the medicinal wine is capable of keeping comfortable and dredging collaterals, diminishing inflammationand alleviating pain; especially, the medicinal wine can have good excellent prevention and adjuvant treatment effects on patients with hypertension, diabetes and insomnia; and the medicinal wine is good in therapeutic effect.