The invention provides a method for rehabilitation of a patient with musculoskeletal disease by using a powered exoskeleton, and relates to the technical field of musculoskeletal disease governance, the method for rehabilitation of the patient with the musculoskeletal disease by using the powered exoskeleton comprises the following steps: the comprehensive rehabilitation effect of the disabled are evaluated, i.e. indexes are measured and summarized at the beginning and the ending of a rehabilitation course, three groups of indexes are considered, and five parameters are respectively used for representing the functional states of a body, namely the cognitive function, the muscle tension, the muscle strength, the severity of pain and the excretion function; the activities in the five parameters include wrist ability, physical ability, action ability, self-service level and productivity at home; four parameters including communication skill, leisure, socialization and occupational fitness are involved, Sp1, the following physical signs are measured for research. According to the method, user data are recorded for multiple times, and the function relation between the change of first and second average characteristics of a period along with time and a vertical component supporting reaction is determined.