47 results about "Pharmaceutical Databases" patented technology

The invention provides a medical drug management system and an optimization method, and relates to the technical field of medical information management, the system comprises a medicine management platform, a medicine database and an information technology support module; wherein the medicine management platform adopts a modular design and comprises a medicine inventory management module, a patient information management module, a medicine use process management module and a report statistics module, and information interaction among the modules is realized through interfaces; the medicine database is used for storing medicine information, medicine inventory information and patient medication information; the information technology support module comprises a bar code scanning module, an RFID technology module and a cloud computing module. By integrating the advanced information technology and the medical management concept, the medical drug management system which is comprehensive in function, efficient and safe is provided, the management process is optimized, the drug use safety is improved, the management cost is reduced, and personalized drug use suggestions and decision support are provided.

The invention discloses an online medical inquiry method based on language reasoning analysis of a large language model. The method comprises the following steps: acquiring doctor seeing information of a patient; constructing a medical knowledge base and a drug database; carrying out keyword extraction on the doctor seeing information of the patient based on the medical concept to construct an inference tuple database containing symptom elements, diagnosis elements, complication elements and treatment elements; and constructing a corresponding semantic network by taking each element in the reasoning tuple database as a node and taking a medical reasoning direction as a relation edge, and forming a reasoning model by the semantic network and a pre-trained large language model. The invention further provides an online medical inquiry system. According to the method provided by the invention, the medical concept can be fused into the man-machine interaction process to optimize the logicality of the inquiry result, so that more reliable medical suggestions are provided for the user.

The invention relates to the technical field of precision medical treatment, in particular to an interpretation system and method for tumor precision medication and a storage medium, and the system comprises a data collection module which is used for collecting gene data, clinical data and drug response data of tumor patients from a plurality of data sources; the data standardization processing module is used for carrying out formatting and standardization processing on the data, so that the data formats are consistent, and effective processing and analysis can be carried out in subsequent modules; the gene data analysis module is used for performing variation analysis according to the gene data of the patient, identifying a gene mutation site and generating a drug sensitivity analysis result; and the drug screening module is used for screening drugs matched with the gene variation sites of the patient from a drug database according to the gene data analysis result, and providing drug dosage recommendation. By adopting the technical scheme of combining a quantum optimization technology and gene data analysis, the technical effect of remarkably improving the drug screening and dose recommendation precision is achieved.

The invention relates to the technical field of medical health and artificial intelligence, and discloses an AI reminding method for a gastroenterology department enteroscope patient to take a laxative, comprising the following steps: S1, guiding the patient to enter an AI interaction interface through a two-dimensional code or an applet entry; s2, generating a personalized medication scheme according to the basic information and the real-time data input by the patient; s3, ensuring that the patient completes an intestinal tract preparation process through a staged guidance and real-time reminding function; s4, performing abnormal reaction identification according to real-time feedback data input by the patient, and adjusting subsequent operation suggestions; and S5, screening potential drug interaction through the integrated drug database, and providing a safe drug use prompt. Personalized data such as age, weight, basic diseases, daily medication and daily work and rest of a patient are collected through the personal information input module, the medication scheme generation module calls a preset algorithm to calculate the optimal medication dosage, medication time nodes are determined, and diet suggestions are generated.

The invention relates to internet-of-things digital intelligent medicine and medicine interaction virtual-real fusion terminal equipment, and aims to solve the problem of medicine selection deviation caused by insufficient medical knowledge of a user in a traditional medicine purchasing process. The device obtains user symptoms through multi-mode interaction (voice, touch screen and video), generates a combined medication scheme based on a cloud medical knowledge base and a medicine database, and introduces a doctor, pharmacist and licensed pharmacist auditing mechanism to guarantee scientific medication and safe medication of the user. The system supports four payment modes and two medicine taking modes (self-pick-up / delivery), realizes full-process intelligentization from symptom analysis to medicine delivery, and adapts to full-process digitalization from body organ part-part symptom to medicine delivery in local dialects. According to the method, the user can be guided to accurately purchase medicines with scientific and safe medication according to the disease symptoms, the correspondence between the medicines purchased by the user and the disease symptoms is improved, the risk of wrong medication of the user is reduced, and the accuracy of scientific and professional medication is improved.

The invention relates to the technical field of drug therapy, in particular to a DRG paid drug therapy scheme analysis and evaluation method, device and system and a medium, and the method comprises the steps: obtaining the medical record information of an inpatient, the medical record information comprises the basic information, diagnosis information and treatment scheme information of the patient; matching a corresponding treatment cost standard in a DRG cost library based on the medical record information; matching a corresponding treatment drug combination in a drug database based on the treatment cost standard and the treatment scheme information; obtaining validity data of each drug in the therapeutic drug combination, and calculating the validity of the drug combination; and generating a drug treatment scheme recommendation sequence based on the drug combination validity, then obtaining historical drug use data of a patient, and correcting the recommendation sequence based on the historical drug use data to obtain a final recommendation scheme. Therefore, the effect of the DRG pharmaceutical composition on the patient can be comprehensively evaluated, and the effectiveness of treatment is improved.

The invention discloses a characterization alignment space-based drug-target interaction prediction method and device. The method comprises the following steps of: initializing parameters of a protein characterization dimension, a drug characterization dimension, a public embedding characterization dimension, the number of layers of a multi-layer sensor and a batch dimension; acquiring a plurality of single-source network data through a plurality of pharmaceutical databases, and performing comparison processing to construct a biological medicine heterogeneous network; according to a comparative learning strategy, integrating a protein target and drug characterization into a public embedding characterization space, and carrying out DTI association training to set a model; and inputting the protein targets and the corresponding drug representations into the trained setting model for DTI prediction to obtain a plurality of most relevant drugs. According to the method, by constructing the biological medicine heterogeneous network, the DTI association related to unknown medicines can be predicted; an embedded characterization alignment frame is built, a high-quality characterization method can be utilized to characterize a biological medicine network and a biological entity, and the problem of training data sparsity can be solved by utilizing contrast loss.

A system is provided.SOLUTION: A system comprising: means for receiving clinical test data and medical record information; means for obtaining drug information from a drug database; means for classifying data using a specific algorithm and extracting features; means for recommending optimal drugs based on the features; and means for generating and transmitting a recommended drug list.SELECTED DRAWING: Figure 1

The present invention relates to the field of precision medicine technology, specifically a system, method, and storage medium for interpreting precise tumor medication, including: a data acquisition module for collecting genetic data, clinical data, and drug response data of tumor patients from multiple data sources; a data standardization processing module for formatting and standardizing the data to ensure a consistent format and enable effective processing and analysis in subsequent modules; a genetic data analysis module for performing variation analysis based on the patient's genetic data, identifying gene mutation sites, and generating drug sensitivity analysis results; and a drug screening module for screening drugs that match the patient's gene mutation sites from a drug database based on the genetic data analysis results, and providing drug dosage recommendations. By adopting a technical solution that combines quantum optimization technology with genetic data analysis, the technical effect of significantly improving the accuracy of drug screening and dosage recommendations is achieved.

An object of a system according to an embodiment is to provide side effect information of a drug described in a prescription quickly and in detail.SOLUTION: A system includes a prescription information inputting unit, a generation AI, an information acquiring unit, and an information providing unit. The prescription information input unit inputs prescription information. The generating AI analyzes the prescription information inputted by the prescription information inputting unit. The information acquisition unit acquires information from a plurality of medicine databases. The information providing unit provides detailed side effect information based on the information acquired by the information acquisition unit.SELECTED DRAWING: Figure 1

The invention relates to the technical field of electronic information, and discloses a method, a device and equipment for establishing a database of drugs with cardiac side effects, and the method comprises the steps: obtaining initial data of drugs with cardiac side effects; converting the initial data to obtain data information which is uniform in language and data format and comprises drugs with heart side effects, and extracting keywords related to the drugs with the heart side effects in the initial data; establishing a corresponding index for the initial data based on the data information of the medicines with the cardiac side effects and the keywords related to the medicines with the cardiac side effects; and performing data mining on the data information of the medicines with the heart side effects, which contains the corresponding indexes, to form a medicine database with the heart side effects. According to the invention, a database for drugs with cardiac side effects is established, data information from different data sources is integrated and standardized, and a unified retrieval and analysis interface is provided.

The invention discloses a cerebral apoplexy thrombolysis patient evaluation method, device and equipment and a storage medium, and the evaluation method comprises the steps: obtaining patient information, obtaining the weight data of a patient from a record database, reading the type of a drug, obtaining a dose coefficient and a conversion factor from a drug database, dose data of the thrombolytic drug is calculated through a first formula and is sent to the display module to be displayed, rapid conversion of the administration dose is achieved, calculation errors of the thrombolytic drug dose are avoided, then blood pressure data, heart rate data and blood oxygen saturation data of a patient are obtained in real time, and the accuracy of thrombolytic drug dose calculation is improved. And judging whether the vital signs are correspondingly located in the first range, the second range and the third range or not, and if not, sending out an alarm signal, so as to accurately judge the vital sign data of the thrombolysis patient, timely discover abnormity and send out an early warning.

The present invention relates to an infusion pump system which enables reliable, low-error workflows without complicated retrofit or integration of barcode scanners and the like. The infusion device is provided with a certain number, especially a plurality of infusion pumps; a central data processing device; a number, in particular a plurality of pharmaceutical containers, each infusion pump communicating with the data processing device and having a connection or receptacle for one of the pharmaceutical containers; the data processing device comprises a drug database having a plurality of drug data items; the corresponding medicine data items are associated with short confirmation codes; a respective pharmaceutical container is associated with one of the medication data items and is identified or marked with a respective short acknowledgement code; a respective infusion pump is associated with an input element for inputting one of the short acknowledgement codes; a respective infusion pump has a configuration unit which retrieves relevant drug data items from a drug database or a local copy thereof depending on a short acknowledgement code entered at an input element and activates drug-specific settings or pump functions configured therein.

Disclosed are methods for assessing severity, determining future risk, matching with a drug treatment, and measuring response to treatment, for memory dysfunction, Alzheimer's disease, and cognitive decline. Also disclosed are new methods of use for drugs and natural compounds repurposed for use in improving memory, as well as for preventing and treating memory disorders, Alzheimer's disease and cognitive decline. All the above-mentioned methods are computer assisted methods analyzing the expression of panels of genes, clinical measures, and drug databases. A universal approach in everybody, as well as a personalized approaches by gender, and by diagnosis, are disclosed.

The invention relates to the field of drug utilization value analysis, and particularly discloses a data stream-based drug utilization value analysis system, which comprises a data layer, an application layer and a user layer, according to the method, the multi-source drug data stream is constructed and stored in the multi-source drug database, and based on systematic management of drug information, drug use errors caused by drug name confusion, dosage errors and dosage form confusion can be reduced, the drug use safety is improved, and the method is beneficial to quickly and accurately retrieving and querying specific types of drug information; by integrating the elderly physiological features and the drug feature information, the drug utilization value analysis model is constructed, the elderly physiological features and the drug features are comprehensively considered, the utilization value of the drug on the elderly can be comprehensively evaluated, and the influence of the drug on the elderly patient can be predicted more accurately.

A system for redistributing medication including a computing device configured to receive a communication regarding a medication donation from a donor, wherein the communication includes donor medication information regarding the medication donation. The computing device further configured to verify the medication donation including verifying the identity of the donated medication. Verifying the identity of the donated medication includes collecting actual medication information. The computing device also configured to enter final medication information corresponding to the medication donation into the medication database. The computing device configured to match the donated medication to a recipient selected from a recipient database as a function of a set of associated recipient data.

The application discloses application of an HTRA1 inhibitor in preparation of a drug for treating pancreatitis-cancer transformation, and belongs to the technical field of medicines.The HTRA1 inhibitor is screened through a drug database, the HTRA1 inhibitor is used to treat a pancreatic cancer cell line and a mouse pancreatitis-cancer transformation in-vivo model, it is proved that the HTRA1 inhibitor Carfilzomib can inhibit the malignant phenotype of Panc1 cells in vitro, and can inhibit the transformation of a KC mouse stimulated by cerulean into a pancreatic ductal adenocarcinoma in vivo, and the application provides a basis for using the HTRA1 inhibitor as the drug for treating pancreatitis-cancer transformation.

The invention discloses a document relationship extraction-oriented adaptive data correction method. The method comprises the following steps of: obtaining a drug database; training a classifier for identifying potential relation facts, including positive training and negative training; a self-adaptive threshold is introduced for each relation fact, false positive is filtered in a self-adaptive mode, and false negative is marked again; iteratively executing de-noising training and data revision based on confidence coefficient; and the interaction between the medicines is identified and output, so that side effects or adverse reactions caused by improper medication are avoided. According to the invention, the distinguishing capability of relation facts is enhanced, and the influence of noisy annotations is reduced; self-adaptive data revision is introduced to revise the relation fact of long-tail distribution; iterative training mines valuable relational facts from a noisy dataset.

The invention discloses a drug interaction prediction method based on similarity network fusion, and relates to the technical field of biomedicine, and the method comprises the steps: integrating drug data sets in a plurality of well-known drug databases, and extracting drug feature data; calculating similarity according to features extracted from the drug data set, and constructing a similarity matrix; the entropy value of each similarity matrix and the pairwise distance between the similarity matrixes are calculated, and the similarity matrix with the maximum information amount is preferentially selected; combining the selected similarity matrixes by adopting a similarity network fusion technology to obtain a fused similarity matrix; constructing an interaction matrix according to the obtained fusion similarity matrix; and training a convolutional neural network (CNN) model by using the fusion similarity matrix and the interaction matrix of the drug, and realizing drug interaction prediction on test data by using the trained CNN model. By combining the similar network fusion technology and the convolutional neural network model, the accuracy and reliability of drug interaction prediction are remarkably improved.

The invention discloses a prescription drug interaction auditing method and system based on a knowledge graph, and relates to the technical field of medical information, and the method comprises the steps: constructing a drug ontology model, executing multi-source knowledge extraction from a drug specification, a clinical guide, a medical literature, a drug database and hospital historical prescription data, performing knowledge fusion to generate uniform medicine knowledge representation, constructing a medicine knowledge graph containing western medicine, traditional Chinese medicine and Chinese and western medicine combined action sub-graphs, performing prescription medicine identification, performing pairwise pairing analysis and multi-medicine combined cascade effect analysis on prescription medicines, and calculating a personalized medication risk value in combination with patient information. According to the method, the multi-drug combination cascade amplification effect and the Chinese and western medicine combination risk can be identified, and personalized drug use risk assessment is realized.

The invention relates to the technical field of biology, in particular to application of losamine as a tyrosinase inhibitor. An FDA approved drug database is screened through an artificial intelligence model, the potential inhibitory activity of the compound on tyrosinase is found, and experiments prove that the compound has good tyrosinase inhibitory activity and transdermal ability.

The invention relates to the field of electrical digital data processing, in particular to a sugammadex antagonism mechanism simulation method which comprises the following steps: S1, establishing a muscle relaxant pharmacokinetics two-chamber model which comprises a central chamber and a peripheral chamber; s2, prefabricating a muscle relaxant database and a sugammadex database, wherein the muscle relaxant database and the sugammadex database respectively comprise drug labels, parameter names and parameter values; s3, adding the muscle relaxant into the pharmacokinetics two-room model to obtain the real-time drug concentration of the muscle relaxant in the central room of the pharmacokinetics two-room model; and S4, adding sugammadex to obtain the real-time drug concentration of the central ventricular muscle relaxant. The simulation of the antagonistic mechanism of sugammadex in the antagonistic muscle relaxant is realized, and the market blank in the field of sugammadex antagonistic mechanism simulation is filled up; and analog quantized data reference can be provided for improving anesthesia safety.

The invention relates to a method for screening depleted uranium renal toxicity action targets and targeted drugs, which comprises the following steps of: 1, searching the action targets related to depleted uranium renal toxicity in a target database, selecting the targets of which the correlation is greater than 10.0, and then performing de-weighting integration to obtain the depleted uranium renal toxicity action targets; the method comprises the following steps: performing protein-protein interaction analysis on uranium-depleted kidney toxicity action targets, hiding free targets, then analyzing unhidden targets to obtain a protein-protein interaction result, obtaining a contribution value of protein according to the protein-protein interaction result, and selecting a core target according to the contribution value; and 3, screening the targeted drug from the drug database based on the core target spot, and classifying and analyzing the screened targeted drug. Through the screening method provided by the invention, the action target of the depleted uranium renal toxicity and the targeted drug for preventing and treating the depleted uranium renal toxicity can be predicted.

Disclosed are methods for assessing severity, determining future risk, matching with a drug treatment, and measuring response to treatment, for stress disorders. Also disclosed are new methods for use for drugs and natural compounds repurposed for use in reducing stress severity, as well as for preventing and treating stress disorders. All the above mentioned methods are computer assisted methods analyzing the expression of panels of genes, clinical measures, and drug databases. A universal approach in everybody, as well as a personalized approaches by gender, and by diagnosis, are disclosed.

The invention relates to an accurate medication time recommendation method and system based on a multi-organization rhythm map. The method comprises the following steps: constructing a drug database and a rhythm expression database; acquiring a drug identifier input by a user, performing retrieval in a database, performing rhythm feature analysis based on a retrieval result, and generating a drug-target rhythm analysis report; based on the drug information queried by the two-stage serial query architecture, querying all biological pathways and related genes in which the drug participates, carrying out standardized conversion on gene identifiers, carrying out rhythm feature analysis, and generating a drug-pathway rhythm analysis report; and taking the generated analysis report as input, carrying out semantic integration and reasoning through a locally deployed large language model, and automatically generating an optimal medication time suggestion. Compared with the prior art, the method has the advantages that batch rhythm characteristic analysis of drug target genes and related pathway genes is realized, the analysis efficiency and repeatability are greatly improved, and the decision intelligence level is improved.

The present invention relates to: a compound for inhibiting SOCS3 activity; a pharmaceutical composition for treating allergic diseases, comprising same as an active ingredient; and the like. More specifically, compounds capable of binding were derived from a drug database through AI-based SOCS3 binding site simulation, and it has been confirmed that these compounds actually inhibit SOCS3 and increase JAK2 kinase activity and the degree of STAT3 phosphorylation, and thus can be used for preventing or treating allergic diseases.

The present invention relates to the field of data processing, and more specifically, to a data processing method for a drug database, the method comprising: obtaining a drug data set, wherein the drug data set includes a plurality of drug data; obtaining preset neighborhood data of any drug data; clustering the neighborhood data into a plurality of clusters; calculating the reference weight of each neighborhood data; using the reference weight of each neighborhood data as the weight, using the LOF algorithm to calculate the local reachable density of the drug data; and using the LOF algorithm to perform anomaly detection based on the local reachable density to remove the abnormal data in the drug database. By analyzing the degree to which the drug data and each neighborhood data belong to the same category, different weights are set for each neighborhood data to improve the accuracy of anomaly detection.

The invention relates to a method for applying a medical big language model of an integrated knowledge graph to drug analysis and diagnosis support. The method comprises the steps of performing streaming analysis and entity recognition on a structured pharmaceutical database file, generating a drug record set containing standardized biomedical entity annotations, and constructing a graph structure knowledge base and a vector index base in parallel; receiving a natural language query, extracting drugs and disease entities and mapping the drugs and disease entities into standardized identifiers; synchronously retrieving the structured evidence set and the text evidence set; assembling an enhanced prompt text containing the task instruction, the verified evidence and the query according to the template; and inputting the large language model subjected to biomedical task fine tuning, and generating a binding response. By adopting the method, the problems of static stiffness, pure language model illusion and insufficient interaction of a structured knowledge base of a traditional system can be solved, reliable decision assistance is provided for replacement treatment and interaction review under the condition of drug shortage, and the drug use risk is reduced.

The invention relates to the technical field of medicine analysis, particularly provides a medicine analysis method and system, electronic equipment and a storage medium, and aims to solve the technical problem that an MALDI-TOF (Matrix-Assisted Laser Desorption / Ionization Time of Flight)-based analysis technology cannot comprehensively, quickly and accurately analyze medicines. In order to achieve the purpose, the method comprises the steps that sample information of a user is obtained; the sample information at least comprises site typing information of the user; verifying the sample information, and judging whether the sample information is valid or not; and if the sample information is valid, obtaining a drug analysis result of the user based on a drug database and a genome library corresponding to the site typing information. Through the implementation mode, the medicine can be comprehensively, quickly and accurately analyzed according to the site typing information of the user, and personalized medication guidance and suggestions are provided for the user, so that the safety and effectiveness of the medicine are improved, adverse reactions are avoided, and personalized precise medication is realized.

The invention relates to the technical field of drug knowledge maps, and provides a drug database knowledge map construction system, which comprises a data acquisition module, an analysis module, a map module, a risk assessment module and a verification module, key feature data information and map abnormal feature parameter information of target compound drugs of various compound structure types in a drug database are collected, drug key feature factors and map abnormal feature characterization values are analyzed, and whether system operation meets the standard or not is determined through a map module; and if not, starting a verification module based on the map structure risk tendency type, and adopting a corresponding processing mode based on the determined reason for not meeting the standard. By converting discrete drug data into a computable and explorable relation network, a structured knowledge graph is provided for drug research and development and clinical research, and system efficiency and accuracy are improved.