The invention discloses a quantum authentication system integrated on a single circuit board. The quantum authentication system comprises an integrated circuit board, a quantum light source module, a card slot, a decoding detection module, a touch screen display chip and a quantum key card formed by an incentive optical modulator chip with a window on which an optical PUF is fixedly packaged, wherein the quantum light source module, the card slot, the decoding detection module and the touch screen display chip are sequentially interconnected and integrated on the integrated circuit board through soldering from left to right and are integrally packaged through a shell. According to the quantum authentication system integrated on the single circuit board, the optical PUF and the incentive optical modulator chip are integrated, and the purpose of position alignment between excitation light and the optical PUF is achieved; the purpose of position alignment between the quantum key card and the decoding detection module is achieved through the wave-front feedback adaptive algorithm, and the stability and the repeatability of the system are greatly improved. The quantum authentication system integrated on the single circuit board also has the advantages of being small in size, light in weight, compact in structure and fast and convenient to use and carry, and is suitable for the fields of quantum security certification, identity recognition and quantum encryption.