The invention discloses a preparation method of an upconversion
fluorescence nanometer material with a nucleocapsid structure. The method comprises the following steps of preparing 3 kinds of solutions by using two kinds of
rare earth oxides 1 and 2, and
sodium hydroxide, and then performing a series of reactions, wherein the
rare earth oxide 1 consists of Yb2O3, a
rare earth activated
ion oxide ( Er<3+>, Tm<3+> or Ho<3+> ) and a rare earth substrate
ion oxide (Gd<3+>, Y<3+>, Lu<3+>, La<3+> or Yb<3+> ), and the rare earth oxide 2 is prepared from the Yb2O3 or the rare earth activated
ion oxide or the rare earth substrate ion oxide or is prepared by mixing the Yb2O3, the rare earth activated ion oxide and the rare earth substrate ion oxide in any proportions. According to the preparation method disclosed by the invention, naked shells are directly dispersed to an
octadecene solution, and the step of removing
cyclohexane is omitted, so that the technology is simple and convenient to operate, and in the process of forming the nucleocapsid structure, the dispersibility of the naked shells is improved, and the
fluorescence intensity of the naked shells after generating the nucleocapsid structure is also notably improved. The upconversion
fluorescence nanometer material has wide application values and prospects in the fields of solar batteries, display devices,
laser anti-counterfeiting, an MRI
radiography agent, biomedical science and the like.