This invention discloses an interaction interface of a set-top box and an operation method, in which, the technical scheme includes search on the interface, program browse and edition, electronic program indication, item-selection and setting menu column, the operation step: 1, picking up the search, program browse, edition, electronic program indication and item-selection menu column, 2, carrying out manual, NIT or automatic searches, classifying and browsing the programs and examining the time arrangement information to alter the audio and video output by the set-top box in format, 3, identifying the programs and storing its information and sorting the programs in the computer, selecting programs to be watched, setting user interface language, its own time zone ciphered code for turning off or locking/de-locking.