The invention relates to an employment and entrepreneurship teaching device which comprises a host, a display screen, a first operating mechanism and a second operating mechanism. A motor works to drive a threaded rod to rotate, then a supporting sliding arm is driven to move from one end of a side groove, and when moving, a liquid pump works to convey disinfectant fluid in a liquid storage box into a groove hole of a rotating rod through a guide pipe, and finally the disinfectant fluid enters a first spraying base through a connecting channel to be sprayed out to disinfect a keyboard, when the supporting sliding arm starts to return to the original position, the liquid pump stops working, the first air heater starts to work to convey hot air into the second spraying base to be sprayed out, the surface of the keyboard is dried, and after the mouse is used, the liquid pump works to convey disinfectant fluid to the spraying head through the internal channel to be sprayed out, so that the mouse is disinfected and cleaned; and then, a second air heater works to convey hot air to a spray head through an internal channel to be sprayed out, the mouse is dried, disinfection of the keyboard and the mouse is completed, indirect contact of a user is avoided, and safe use is guaranteed.