The invention discloses a transformer substation protection system. The system comprises a fire alarm system, a small animal repelling system, a signal protection device and a steel structured kit, wherein the fire alarm system comprises a trigger device, a fire alarm controller, a fire alarm device, a fire-fighting linked controller and automatic fire-fighting equipment, the animal repelling system comprises a snake repeller, a mouse repeller, an wireless integrated controller and a microcontroller, the snake repeller and the mouse repeller are electrically connected with the wireless integrated controller, the signal protection device comprises a cable and a cable signal transmitter, an additional wire is arranged on the lower end of the cable, signal generators are arranged on both ends of the additional wire, the signal generators are synchronized with the signal transmitter, a synchronous controller is arranged in the cable signal transmitter, and a same-frequency device is arranged in the synchronous controller. The transformer substation protection system can conduct fire pre-warning, small animal repelling and signal transmission protection.