The invention relates to an electric lead screw drive mechanism for an automatic transmission. The electric lead screw drive mechanism comprises a gearshift motor, a gear selection motor, a screw rod connection sleeve, a screw rod, a screw rod nut, a gearshift shifting fork, a lead screw nut sleeve, a gear selection shifting fork, a gear selection block, a gear selection shaft sleeve, a gear selection pin, a gearshift pin and a gearshift shaft, wherein the gearshift motor, the screw rod connection sleeve and the screw rod are sequentially connected; the screw rod nut sleeves the screw rod and is fixedly connected with the lead screw nut sleeve; the gearshift shifting fork is connected with the gearshift pin and the gearshift shaft respectively; the gearshift pin is slidably connected with the lead screw nut sleeve; the gear selection motor, the gear selection shaft sleeve and the gear selection shifting fork are sequentially connected; the gear selection pin is connected with the gear selection shifting fork and the gear selection shifting block respectively; the gear selection shifting block is connected with the gearshift shaft. Compared with the prior art, the electric lead screw drive mechanism disclosed by the invention is high in reliability, convenient to install, and low in cost.