Oil-in-water type garlicin-garlic oil sub-microemulsion as well as method for preparing same
A sub-microemulsion, allicin technology, applied in the field of medicine, can solve the problems of poor water solubility of allicin, damage to gastrointestinal mucosa, easy to be destroyed by gastric juice, etc., to improve physical and chemical stability, improve bioavailability, facilitate The effect of industrial production
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Embodiment 1
[0058] Prescription: 0.5g of allicin, 5g of egg yolk lecithin, 10g of medium-chain oil for injection, appropriate amount of sodium hydroxide, 2.2 of glycerin, and the rest is water for injection, a total of 100ml.
[0059] Process:
[0060] (1) Preparation of oil phase: Add medium chain oil for injection into the preparation tank, control the temperature of medium chain oil for injection at 80°C, add egg yolk lecithin, stir vigorously until dissolved, cool down to 30°C, add drug, and stir vigorously mix;
[0061] (2) Preparation of water phase: Stir water and glycerin at 30°C for 5 minutes to make them completely miscible;
[0062] (3) At 30°C, add the oil phase to the water phase and stir vigorously to form colostrum;
[0063] (4) adjust the pH value to 5 with sodium hydroxide;
[0064] (5) Homogenizer: adjust the homogenization pressure to 500bar in the first step, and then adjust it to 1000bar in the second step, and homogenize the solution repeatedly;
[0065] (6) The ...
Embodiment 2
[0067] Prescription: Allicin 1.0g, soybean lecithin 0.2g, soybean oil for injection 5g, glucose 5.0g, appropriate amount of sodium hydroxide, the rest is water for injection, 100ml in total.
[0068] Process:
[0069] (1) Preparation of the oil phase: Add soybean oil for injection into the preparation tank, control the temperature of soybean oil for injection at 50°C, add soybean lecithin, stir vigorously until dissolved, cool down to 30°C, add the drug, and stir vigorously to mix;
[0070] (2) Preparation of water phase: Stir water and glucose at 35°C for 5 minutes to make them completely miscible;
[0071] (3) At 30°C, add the oil phase to the water phase and stir vigorously to form colostrum;
[0072] (4) adjust the pH value to 5 with sodium hydroxide;
[0073] (5) Homogenizer: adjust the homogenization pressure to 600bar in the first step, and then adjust it to 1500bar in the second step, and homogenize the solution repeatedly;
[0074] (6) The emulsion prepared above w...
Embodiment 3
[0076] Prescription: 1.0g allicin, 1g egg yolk lecithin, 20g soybean oil for injection, 2g caprylic acid glyceride, 2.5g glycerin, 0.01g oleic acid, appropriate amount of sodium hydroxide, the rest is water for injection, 100ml in total.
[0077] Process:
[0078] (1) Preparation of the oil phase: Add soybean oil for injection, glyceryl caprylate and oleic acid into the preparation tank, control the temperature at 60°C, add egg yolk lecithin, stir vigorously until dissolved, cool down to 30°C and add the drug, Mix vigorously;
[0079] (2) Preparation of water phase: Stir water and glycerin at 40°C for 5 minutes to make them completely miscible;
[0080] (3) At 30°C, add the water phase to the oil phase, stir vigorously to form colostrum;
[0081] (4) adjust the pH value to 5 with sodium hydroxide;
[0082] (5) Homogenizer: adjust the homogenization pressure to 400bar in the first step, and then adjust it to 2000bar in the second step, and homogenize the solution repeatedly;...
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