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Rare earth doped hydroxyfluorapatite monocrystal nanometer wire and preparation method thereof

A fluorine-containing hydroxyapatite, single-crystal nanotechnology, applied in nanotechnology, nanotechnology, nanotechnology and other directions for materials and surface science, can solve the problems of unseen, crystallinity, homogeneity, monodispersity, Nano-size and efficiency cannot achieve optimization and other problems, and achieve the effect of stable product quality, low cost and good process repeatability

Inactive Publication Date: 2011-11-23
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There are high-temperature and low-temperature methods for the synthesis of fluoroapatite nanomaterials, but the materials obtained so far cannot achieve an optimal combination of crystallinity, uniformity, monodispersity, nano-size and performance, which is not conducive to fully Taking advantage of the advantages of this type of material, there have been no reports of F(H)A ultra-fine nanowires (diameter ≈ 5nm) with controllable appearance and surface properties obtained directly by hydrothermal synthesis and controlled by rare earth elements. arrive

Method used

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  • Rare earth doped hydroxyfluorapatite monocrystal nanometer wire and preparation method thereof
  • Rare earth doped hydroxyfluorapatite monocrystal nanometer wire and preparation method thereof
  • Rare earth doped hydroxyfluorapatite monocrystal nanometer wire and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0026] Embodiment 1, the preparation of single crystal nanowire

[0027] (1) Mix 3mL of 0.28M calcium nitrate aqueous solution, 0.3mL of 0.28M ytterbium nitrate aqueous solution, 0.3mL of 0.28M sodium fluoride aqueous solution, 3mL of 0.16M sodium phosphate aqueous solution, 0.8g of sodium hydroxide, 8mL of anhydrous Add ethanol and 20mL of oleic acid into a 50mL polytetrafluoroethylene hydrothermal reaction kettle, and stir evenly. In the above reaction system, the molar ratio of sodium phosphate, sodium fluoride, ytterbium nitrate and calcium nitrate is 0.57:0.1: 0.1:1, the pH of the system is 6.5.

[0028] (2) Seal the reactor in (1), and react at 150° C. for 36 hours. Then cool to room temperature, open the reactor, wash with absolute ethanol and chloroform, and dry to obtain the product powder. The product is identified as hydroxyapatite by X-ray powder diffraction, and the powder X-ray diffraction results are as follows: figure 1 shown; the material morphology was obt...

Embodiment 2

[0029] Embodiment 2, the preparation of single crystal nanowire

[0030] (1) 0.28M calcium nitrate aqueous solution 3mL, 0.28M lanthanum nitrate aqueous solution 0.3mL, 0.28M sodium fluoride aqueous solution 0.45mL, 0.16M sodium hydrogen phosphate aqueous solution 3mL, 1.2g sodium hydroxide, 8mL anhydrous Add water ethanol and 20mL of oleic acid into a 50mL polytetrafluoroethylene hydrothermal reaction kettle, and stir evenly. In the above reaction system, the molar ratio of sodium phosphate, sodium fluoride, lanthanum nitrate and calcium nitrate is 0.57:0.15 : 0.1: 1, the pH of the system is 7.5.

[0031] (2) Seal the reactor in (1), and react at 120° C. for 48 hours. Then cool to room temperature, open the reactor, wash with absolute ethanol and chloroform, and dry to obtain the product powder. The resulting product is identified by X-ray powder diffraction and transmission electron microscopy and component analysis (similar to the single crystal nanowire prepared in Examp...

Embodiment 3

[0032] Embodiment 3, the preparation of single crystal nanowire

[0033] (1) Mix 3mL of 0.28M calcium nitrate aqueous solution, 0.3mL of 0.28M cerium nitrate aqueous solution, 0.45mL of 0.28M sodium fluoride aqueous solution, 3mL of 0.16M sodium dihydrogen phosphate aqueous solution, 1.8g of sodium hydroxide, 10mL of Add absolute ethanol and 20mL of oleic acid into a 50mL polytetrafluoroethylene hydrothermal reaction kettle and stir evenly. In the above reaction system, the molar ratio of sodium dihydrogen phosphate, sodium fluoride, cerium nitrate and calcium nitrate is 0.57:0.15:0.1:1, the pH of the system is 8.0.

[0034] (2) Seal the reactor in (1), and react at 180° C. for 24 hours. Then cool to room temperature, open the reactor, wash with absolute ethanol and cyclohexane, and dry to obtain the product powder. The resulting product is identified by X-ray powder diffraction and transmission electron microscopy and component analysis (similar to the single crystal nanowi...

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Abstract

The invention provides a rare earth doped hydroxyfluorapatite monocrystal nanometer wire and a preparation method thereof. The preparation method comprises the following steps: under an alkaline condition, enabling calcium nitrate, phosphate, sodium fluoride and rare earth nitrate to react with one another, thereby acquiring a hydroxyfluorapatite monocrystal nanometer wire, wherein the rare earthnitrate is at least one of lanthanum nitrate, cerous nitrate, praseodymium nitrate, neodymium nitrate, promethium nitrate, samarium nitrate, europium nitrate, gadolinium nitrate, terbium nitrate, dysprosium nitrate, holmium nitrate, erbium nitrate, thulium nitrate, ytterbium nitrate and lutecium nitrate. A monocrystal nanometer wire prepared by using the method can be further processed into a repairing material for biologic sclerous tissues, such as artificial bone, bone cement, and the like, and can be used for the basic research and clinical practice in the fields related to biological materials, organizational engineering, and the like.

Description

technical field [0001] The invention relates to a monodisperse one-dimensional nanometer material and a preparation method thereof, in particular to a rare earth-doped fluorohydroxyapatite single crystal nanowire and a preparation method thereof. Background technique [0002] Hydroxyapatite (Ca 10 (OH) 2 (PO 4 ) 6 , HA) has been widely used as a bone implant material, mainly due to its good biocompatibility and being one of the few materials that can form strong chemical bonds with bone in the body. However, problems such as poor thermal stability (ie pyrolysis) and fast decomposition rate in the biological environment limit its application to a certain extent. People overcome some performance defects of HA itself by doping some other elements in a small amount into HA, such as doping rare earth elements such as cationic strontium, magnesium, zinc, and lanthanum into its crystal or doping carbonate, chloride ion, fluorine, etc. ions etc. [0003] The physicochemical an...

Claims

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Application Information

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IPC IPC(8): C01B25/32B82Y30/00B82Y40/00A61L27/32
Inventor 王训惠俊峰庄京
Owner TSINGHUA UNIV
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