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Black phosphorus quantum dot coated by core-shell metal organic framework, and preparation method and applications thereof

A metal-organic framework and quantum dot technology, applied in the field of nanomedicine, can solve the problems that chemical drugs cannot accurately reach the core area of ​​tumors, kill tumor cells, and have toxic and side effects, and achieve good photothermal conversion efficiency, good biocompatibility, The effect of low cytotoxicity

Active Publication Date: 2019-04-12
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no effective treatment for many tumors, and traditional treatment methods are subject to many limitations due to poor curative effect, side effects and complications.
Chemotherapy is the most commonly used clinically, but the specificity of chemical drugs is not high. While killing tumor cells, it also has a damaging effect on normal cells in the body, especially cells that proliferate vigorously.
Obvious toxic side effects lead to a decline in the quality of life of patients, and chemical drugs cannot accurately reach the core area of ​​​​the tumor

Method used

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  • Black phosphorus quantum dot coated by core-shell metal organic framework, and preparation method and applications thereof
  • Black phosphorus quantum dot coated by core-shell metal organic framework, and preparation method and applications thereof
  • Black phosphorus quantum dot coated by core-shell metal organic framework, and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1: Preparation of black phosphorus quantum dots coated with zeolite imidazolate framework.

[0038] 50 mg of black phosphorus crystals were ground in an agate mortar for 15 minutes under an argon atmosphere, then 2 mL of dimethyl sulfoxide was added, and the probe was sonicated for 15 hours under a nitrogen atmosphere. Disperse the resulting mixture in 20 mL of dimethyl sulfoxide, centrifuge at 7500 rpm for 25 min, mix two-thirds of the supernatant with an equal volume of methanol, centrifuge at 9500 rpm for 25 min, and redisperse in 20 mL of methanol . Transmission electron microscope and UV-Vis absorption spectra of black phosphorus quantum dots are shown in figure 1 shown. Sodium polystyrene benzene sulfonate was added to the methanol solution of black phosphorus quantum dots. After 1 hour, the surface-modified black phosphorus quantum dots were obtained by centrifugation at 9500 rpm, washed with methanol several times, and finally dispersed in 1 mL of met...

Embodiment 2

[0040] Example 2: Preparation of black phosphorus quantum dots coated with a core-shell metal organic framework.

[0041] The black phosphorus quantum dots coated with the zeolite imidazolate skeleton obtained above were dispersed in ethanol, mixed with the ethanol solution of copper nitrate at 30°C, re-dispersed in ethanol after centrifugation, and further mixed with trimesis at 60°C Formic acid reaction. The obtained material was dispersed in ethanol and reacted with the ethanol solution of ferric chloride and trimesic acid in sequence at 60° C. to obtain the black phosphorus quantum dots coated with the metal-organic framework of the core-shell mechanism. The X-ray diffraction pattern, transmission electron microscope image, infrared spectrum and ultraviolet-visible absorption spectrum of black phosphorus quantum dots coated with core-shell structure metal-organic framework are as follows figure 2 shown.

Embodiment 3

[0042] Example 3: Structure, morphology and fluorescence properties of black phosphorus quantum dots coated with core-shell metal-organic frameworks.

[0043] Place the powder of the sample on the sample stage of the X-ray powder diffractometer to keep the surface smooth, and scan it at 5° to 60°. The sample was ultrasonically dropped onto a flat and clean silicon wafer surface, and its morphology was observed under a scanning electron microscope. The sample was ultrasonically dropped onto a copper grid, and its morphology was observed under a transmission electron microscope. Mix the sample with potassium bromide powder and grind it thoroughly, and press it into a sheet under a pressure of 25 MPa to test its infrared spectrum. Disperse the sample in ultrapure water or phosphate buffer solution (pH7.4, 7mM) to prepare a mother solution with a concentration of 10mg / mL. Take a certain amount of mother liquor and dilute it with a corresponding solvent such as ultrapure water or...

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Abstract

The invention discloses a black phosphorus quantum dot coated by a core-shell metal organic framework. The quantum dot is characterized in that a metal organic framework is used as a matrix to coat the black phosphorus quantum dot. The metal organic framework is a composite of one or both of HKUST-1 and MIL-100. Compared with the prior art, the nano material of the invention has strong targeting and small toxic and side effects, and the microenvironment of cancer cells is utilized to degrade the metal organic framework so as to release iron ions and copper ions which are further reduced to ferrous ions and cuprous ions and to induce the decomposition of hydrogen peroxide and nitrosoglutathione to generate hydroxyl radicals and nitric oxide. The black phosphorus quantum dot can generate heat under near-infrared radiation so as to increase the temperature of tumor cells, and to achieve synergistic treatment. Finally, the material is completely degraded into metal ions and phosphate radicals which are then excreted to the outside of the body.

Description

technical field [0001] The invention relates to a black phosphorus quantum dot coated with a core-shell metal organic framework and a preparation method and application thereof, belonging to the field of nanomedicine. Background technique [0002] Malignant tumors have become a major disease that threatens human health and society. In my country, the 5-year survival rate of malignant tumor patients is only 30.9%, and the survival rate of cancer patients in rural areas is only half of that in cities. Cancer has surpassed cardiovascular disease and has become the "number one killer" of death. The high incidence of cancer not only increases the pain of patients, but also brings a heavy economic burden to families and society. At present, there is no effective treatment for many tumors, and traditional treatment methods are subject to many limitations due to poor curative effect, side effects and complications. Chemotherapy is the most commonly used clinically, but the specif...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K49/22A61K47/69A61K41/00A61K38/06A61K9/51A61K47/22A61P35/00
CPCA61K9/5123A61K38/06A61K41/0052A61K49/0002A61K49/0017A61K49/0093A61K49/225A61K47/6949A61P35/00A61K2300/00
Inventor 王雪梅杜天宇秦肇建姜晖
Owner SOUTHEAST UNIV
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