62results about How to "Increase structural diversity" patented technology

The invention discloses a preparation method of biomacromolecules modified by linking chemical molecules disclosed as Formula I or Formula II by a one-pot process, which comprises the following steps: dissolving compounds disclosed as Formula A or Formula B in a solvent, and directly reacting in the presence of an alkali and a ligand by using an azide transfer reagent and a copper catalyst in a buffer solution with the pH value of 4.0-11.0 to generate the compounds disclosed as Formula I or Formula II, wherein R1 and R2 are respectively and independently selected from biomacromolecules or chemical micromolecules, and biomacromolecules or chemical small molecules when being different. The novel method for chemically modifying biomacromolecules has the advantages of simple process route and mild reaction conditions. By adopting imidazolyl sulfonyl azide hydrochloride or trimethyl silyl azide as the azide transfer reagent, the method has high operational safety, does not need to separate or purify the intermediate product, saves the procedures, lowers the operation difficulty, can be used for preparing biomacromolecules with different chemical modifications, and is very suitable for industrial application.

The invention relates to an amino-protected 3-hydroxy adamantane glycine benzothiazole-2-thiol active ester as well as a preparation method and application thereof. The thiol active ester is prepared by virtue of reaction between amino-protected 3-hydroxy adamantane glycine and dibenzothiazyl disulfide. The invention further discloses application of the compound in the preparation of a saxagliptin intermediate and saxagliptin. The invention provides a brand new chemical structure. The preparation method is simple and low in cost; the compound is applicable to the preparation of saxagliptin, so that the preparation process can be effectively simplified; and the reaction is mild, and the compound has a wide generalization prospect.

The invention discloses an assembly type prefabricated structure wallboard unit and connecting joints thereof. The assembly type prefabricated structure wallboard unit is a prefabricated component which is provided with two surfaces and four junction faces and mainly made of concrete. The assembly type prefabricated structure wallboard unit comprises reserved connecting rebars exposed out of the four junction faces. The exposed parts of the reserved connecting rebars on the two vertical junction faces are in a [ shape or an L shape and form the vertical junction face reserved rebars. The reserved connecting rebars comprise the edge component reserved connecting rebars and non-edge component reserved connecting rebars between the junction face at the upper end and the junction face at the lower end, and exposed parts of the rebars form the upper and lower end reserved rebars. The connecting joints comprise the vertical seam connecting joint and the horizontal seam connecting joint. The wallboard unit and the connecting joints have the advantages that site construction is convenient, safety and reliability are achieved, and the wallboard unit and the connecting joints have the same performance of a cast-in-place structure, and the structure design principle that the bearing force of the joints is higher than that of the components is achieved.

The invention discloses a dihedral angle information auxiliary energy function selection based protein structure prediction method. extracting dihedral angle information according to a Ramachandran plot corresponding to a protein residue; performing assessment on conformation by using the energy functions and the dihedral angle information in a Rosetta algorithm; giving different weights to two fractions, designing a new scoring function, and performing selection on the fragment assembled conformation by using the scoring function so that the influence on the three-dimensional structures of proteins due to inexact energy functions can be reduced; and performing global search and local search on the conformation, and performing enhancement on local structures on the basis of guaranteeing the global topological structure of the constellation so that more near-native structures can be obtained. Thus, the dihedral angle information auxiliary energy function selection based protein structure prediction method with good sampling capabilities and high prediction precision can be provided.

The invention discloses lysinibacillus fusiformis and an application thereof in land reclamation and ecological reconstruction in a mining area. The strain is the lysinibacillus fusiformis, and has acollection number of CGMCC No. 9799. The strain is capable of improving the nutrient content of land reclamation soil in the mining area, and has obvious effects for improving the content of organic matters, alkali-hydrolyzale nitrogen, rapidly available potassium and available phosphorus in the land reclamation soil in the mining area. Moreover, further experiments prove that, the lysinibacillusfusiformis is capable of further improving the biomass of crops, and for culture of wheat or oilseed rapes, the biomass of crops in the land reclamation soil in the mining area can be improved; particularly important, due to use of the lysinibacillus fusiformis, the community structure of soil microorganisms can be effectively and obviously changed, the microbial diversity of the soil is improved,and the quantity of microbes is effectively increased. Therefore, remediation of the microbial community in the soil is accelerated, and the lysinibacillus fusiformis can be widely applied to remediation of the land reclamation soil in the mining area.

The invention discloses a ketene triazole compound and a synthesis method thereof. The structural formula of the compound is disclosed in the specification. Alkyl or aryl azide and various substituted 2-furancarbinol used as initial raw materials are subjected to Lewis-acid-promoted [3+2]-cycloaddition/furan ring opening cascade reaction to generate a (E)-configuration 1,2,3-triazole and ketene/aldehyde conjugated skeleton structure. The method is simple to operate, the reagent is the low-cost Lewis acid, and the substrate has wide application range; and thus, the method can be used for synthesizing a series of high-functional-group substituted complex ketene triazoles, and has the advantages of high economical efficiency of steps, diversified product structures and stereospecificity of (E)-configuration.

The invention provides a resonance transformer structure, which comprises a first winding base, a primary winding, a plurality of secondary windings and a magnetic core group, wherein the first winding base comprises a body and a channel, wherein the channel passes through the body; and the body is provided with a first winding zone and a plurality of second winding zones of single grooves; the first winding zone is provided with a plurality of lead pins; the plurality of second winding zones of the single grooves are arranged at the two sides of the first winding zone; the primary winding iswound on the first winding zone of the first winding base, and is connected with the plurality of lead pins; the plurality of secondary windings are respectively wound on the plurality of second winding zones of the single grooves on the first winding base; and a part of the magnetic core group is arranged in the channel of the first winding base. The resonance transformer structure can enhance current transfer power, and reach the purpose of stably controlling a leakage inductance value; and meanwhile, the volume of the resonance transformer is thinned. In addition, the output voltage of theresonance transformer can be increased, thus being high in structure diversity, reducing manufacturing cost, and the like.

The invention discloses a method for producing compound fungus feed and edible mushrooms at the same time. The method mainly comprises the steps that, several animal feed common raw materials comprising corn, wheat, rice, wheat bran and cake type protein are evenly mixed with one or more of agricultural product leftover crude cellulose raw materials, and the fixture is used as the culture media of the edible mushrooms including ganoderma fungus, hericium erinaceus fungus, agrocybe cylindracea fungus and pleurotus eryngii fungus; after the mushrooms grow out, each culture medium existing after the fungus grow out are evenly mixed with cordyceps fungus culture medium produced with a conventional method according to a ratio, after each mixture is smashed roughly, each mixture, the cake type protein and corn flour are fine smashed, and then the compound fungus feed is generated. By the adoption of the method, the problem that hormones and antibiotics are added to feed in the feed industry for a long time, hormones and antibiotics residuals exist in animal end products, and then after people eat the animal end products, the hormones and antibiotics residuals do harm to the health of people is solved, the pollution to the environment in the process of producing the agricultural product leftovers is reduced, the waste is recycled, and the purposes of resource recycling and efficient utilization are achieved.

The invention discloses a method for improving methane gas production rate of anaerobic digestion of sludge and reducing ecological toxicity of heavy metals, and belongs to the technical field of environmental protection. The method comprises the following steps: carrying out high-temperature pyrolysis on straws serving as a raw material under an anaerobic condition to obtain straw biochar, and carrying out chemical modification on the straw biochar under an alkaline condition to obtain an iron-manganese oxide nanoparticle loaded biochar material; adding the iron-manganese oxide nanoparticle loaded biochar material into an anaerobic digestion device according to a certain proportion, and carrying out anaerobic fermentation, so that the stability of the anaerobic digestion process can be greatly enhanced, the methane gas production rate can be increased, the ecological toxicity of heavy metals can be reduced, and the adsorption capacity to heavy metal ions can be improved.

The invention relates to a self-assembly modular robot unit, a robot and an assembly and control method. Self-assembly can be achieved through the provided self-assembly modular robot unit, butt joint with other robots and objects can be automatically completed through sensing and control, a combined body formed after butt joint has the overall movement capacity and the joint movement and operation capacity, and the composite movement characteristic from a wheel type/crawler belt to a joint type is achieved. Therefore, the characteristic that group robots are not connected or are weak in connection can be overcome, cross-mode movement is achieved, the structural diversity of the combined robot is improved, the robot forms such as snakelike robot forms and multi-legged robot forms are constructed, the assembling modes are flexible and diversified, and single robots can complete tasks such as obstacle crossing and carrying beyond the self-ability through combination.

The invention discloses a preparation method and application of a multi-target inhibitor acting on QC and GSK-3 beta. The structural general formula of the multi-target inhibitor prepared by the method is shown in the specification. According to the invention, according to active center crystal structures of target QC and GSK-3 beta zymoprotein, multiple high-activity pharmacophores are integrated, the multi-target inhibitor capable of acting on QC and GSK-3 beta at the same time is prepared through framework transition and recombination design, the multi-target inhibitor is molecules with multiple target points and high activity, the molecular structure diversity of a lead drug is remarkably expanded, and the research and development of innovative anti-AD drugs and AD diagnostic kits areactively promoted, and the preparation method of the multi-target inhibitor provided by the invention is simple and easy to operate.

The invention discloses a rigid functional ligand-cyclometalated bridge-functional ligand type iridium complex framework. According to the rigid functional ligand-cyclometalated bridge-functional ligand type iridium complex framework, a complex contains a bridge ligand capable of being functionally modified, and the complex can be coordinated with two iridium metal centers at the same time; meanwhile, each iridium metal center can be coordinated with other two peripheral functional ligands to form a rigid molecular framework with two metal centers and five ligands; at most three different bidentate ligands exist in a traditional organic iridium complex, that is to say, three modification points are provided; at most five different bidentate ligands exist in the novel molecular framework provided by the invention, so that the number of modification points reaches five, the structural diversity and the property regulation space of the organic metal iridium complex are remarkably increased, and the organic metal iridium complex has potential application value in the important fields of development of high-performance luminescent materials, catalytic systems, solar conversion systems,chemical and biological detection and the like.

The invention provides a Pickering emulsion. The Pickering emulsion comprises an oil phase and a water phase, wherein the volume ratio of the oil phase is 4.2%-90%, Alg-beta-CD is dispersed in the water phase, and AzoC12 is dispersed in the oil phase. The invention further provides a super-amphiphilic host-guest alginate-based anisotropic structure soft substance prepared from the Pickering emulsion. A novel amphiphilic-controllable super-amphiphilic Alg-beta-CD/AzoC12 self-assembly is designed and prepared, has better interface adsorption performance and can be used for preparing a W/O/W emulsion with good stability by a phase inversion method. The amphipathy of the super-amphiphilic aggregate can be properly adjusted on the basis of host-guest action, an ideal and convenient strategy can be provided for phase separation behavior control of the host-guest multiphase emulsion, so that the structural diversity of the soft material is realized, and the Pickering emulsion has potential application value in colloidal materials.

The invention provides an electronic device. The electronic device specifically comprises a flexible screen, a shell and a movable insertion part, wherein the shell comprises a front shell and a rearshell which are clamped to form a first accommodating space, part of the flexible screen is arranged on one side, deviating from the rear shell, of the front shell, and part of the flexible screen isarranged in the first accommodating space. A second containing space is formed in the front shell, the movable inserting part comprises a supporting part at least partially arranged in the second containing space and a rolling shaft arranged at the end, away from the second containing space, of the supporting part, and the movable inserting part can move in the opening and closing direction of theflexible screen so that the electronic equipment can be opened and closed; when the electronic equipment is in a closed state, part of the flexible screen is further arranged on the rolling shaft, and when the electronic equipment is in an unfolded state, part of the flexible screen is further arranged on the rolling shaft and the supporting part. Through cooperation of the flexible screen, the shell and the movable insertion part, the electronic equipment in a new form is provided, the size of the electronic equipment can be controlled under the condition that the thickness of the electronicequipment is not increased, and the structural diversity of the electronic equipment is improved.

The invention discloses a method for preparing carbonic ester-carbamate mixed ester based on cellulose carbonic ester. The method comprises the following steps: 1) by taking cellulose carbonic ester as a raw material; 2) dissolving the cellulose carbonic ester of the step 1) into a solvent at 10-120 DEG C so as to obtain a product A; 3) putting isocyanate and a catalyst into the product A, and carrying out a reaction for 0.1-10 hours at 20-100 DEG C so as to obtain a product B; 4) putting an anti-solvent into the product B, filtering a precipitate substance, washing and purifying precipitate,and drying, thereby obtaining a cellulose carbonic ester-carbamate mixed ester material. The cellulose carbonic ester-carbamate mixed ester material prepared by using the method is of a novel structure, has the specificity of properties of carbonic ester groups and carbamate groups, has instruction significances in achieving structural diversity and high-value utilization of cellulose and in addition is simple in preparation method and convenient to operate, and the solvent can be recycled.