The present invention provides a medical device, which comprises: a microneedle array, and a coating disposed on the microneedles, wherein the coating comprises: a local anesthetic selected from lidocaine, Prilocaine and combinations thereof; and a local anesthetic dose sustained release component selected from the group consisting of alpha 1 adrenergic agonists, alpha 2 adrenergic agonists and combinations thereof; wherein based on the coating The total weight of solids, the local anesthetic is present in an amount of at least 1% by weight, and wherein the dose-extending component / local anesthetic weight ratio is at least 0.0001; a medical device comprising An array of dissolving microneedles comprising: a dissolvable matrix material; at least 1% by weight of a local anesthetic selected from the group consisting of lidocaine, prilocaine, and combinations thereof; and a local anesthetic dose sustained release component , the local anesthetic dose-sustaining release component is selected from α1 adrenergic agonist, α2 adrenergic agonist and combinations thereof; wherein the weight ratio of the dose-sustaining component / local anesthetic is at least 0.0001, and wherein the weight % based on the total weight of solids in all portions of the dissolvable microneedles containing the local anesthetic; a method of using the device to provide sustained release of a locally delivered dose of local anesthetic in mammalian tissue; and a method of manufacturing method of the device.