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Bovine tuberculosis (TB) is a chronic disease of animals caused by a bacteria called. Mycobacterium bovis, (M.bovis) which is closely related to the bacteria that cause human and avian tuberculosis.
Application of TRIM58 gene in regulating host anti-mycobacterium bovis infection
PendingCN122272811AMycobacterium InfectionsBacterial Viability
This invention discloses the application of the TRIM58 gene in regulating host resistance to Mycobacterium bovis infection. A bovine macrophage cell line with TRIM58 gene knockout was constructed using CRISPR / Cas9 technology. Results showed that TRIM58 knockout significantly inhibited intracellular survival of Mycobacterium bovis and reduced infection-induced cell death; reintroduction or overexpression of TRIM58 restored or enhanced bacterial viability. Therefore, this invention is the first to demonstrate that TRIM58 is a negative regulator of host resistance to Mycobacterium bovis infection, and that inhibitors of the TRIM58 gene can be used to prepare drugs against Mycobacterium bovis infection or to treat bovine tuberculosis. This invention fills a research gap in the field of TRIM58 in bovine tuberculosis and provides an effective tool for screening and studying the mechanisms of action of anti-bovine tuberculosis drugs.
Owner:HUAZHONG AGRI UNIV