The invention belongs to the technical field of mechanical numerical control machining, and relates to a multi-constraint five-shaft machining feeding rate setting method. According to the method, firstly, feeding rate values of sampling points are determined according to chord height difference constraints, cutter shaft angular speed and speed constraints of shafts of a machine tool, and an original feeding rate curve is constructed; by means of a proportional control algorithm, feeding rate values of acceleration or saltus poor points are determined again, so that acceleration and saltus gradually reduce according to the synclastic rule; a curve evolution strategy is adopted, the original feeding rate curve deforms in a one-point constraint or multi-point constraint mode, so that the original feeding rate curve deforms smoothly to a designated feeding rate updating position, and smooth transition of an adjustment area and a non-adjustment area of the feeding rate curve is achieved. Off-line setting of a five-shaft machining adaptability feeding rate is achieved, parallel constraint requirements of five-shaft machining geometric characteristics, process characteristics and machine tool drive characteristics are met, and machining accuracy, quality and efficiency are guaranteed.