4 results about "Immunoglobulin-binding protein" patented technology

Immunoglobulin (Ig) binding proteins having one or more domains having highly hydrophobic amino acids with branched side chains (Iso, Leu, Val), or aromatic amino acids (Tyr, Phe, or Trp) corresponding to position 4 or 6 or 8 of the Ig binding protein of SEQ ID NO: 1 or functionally similar proteins are provided. The disclosed proteins have superior properties for highly efficient purification methods for antibodies (immunoglobulins), for example, the proteins have high binding capacity and high chemical stability. Also provided are affinity matrices that include the disclosed Ig binding proteins, uses of these Ig binding proteins and / or affinity matrices for affinity purification of immunoglobulins, and methods for affinity purification using the disclosed Ig binding proteins.

The present disclosure relates to new serum stable non-immunoglobulin binding proteins based on ubiquitin scaffold that are highly specific for membrane-bound receptor tyrosine kinase (Her2). The disclosure provides novel specific recombinant Her2 binding proteins with high serum stability essentially combined with high temperature stability and high affinity for Her2 for uses in medical applications for diagnosis or therapy of cancer with Her2 overexpression, in particular, for radiopharmaceutical applications.

The application discloses Staphylococcus aureus specific nanobodies and a sandwich ELISA detection method and application thereof, and belongs to the technical field of foodborne pathogenic bacteria detection. The Staphylococcus aureus specific nanobodies provided by the application include at least one of Nb55, Nb90, Nb156 and 3Nb156. The application constructs a sandwich ELISA based on HRP-labeled monovalent or trivalent nanobodies to detect Staphylococcus aureus, which effectively avoids unnecessary interaction between the crystallizable fragment and the immunoglobulin binding protein, and is successfully used for detection in actual samples, has the advantages of time saving, low cost, sensitivity and the like, and has important reference value for wide promotion of nanobodies in the field of foodborne pathogenic bacteria detection.