18 results about "Tissue markers" patented technology

To provide a method for evaluating the quality of neuroretina for transplantation and neuroretina sheets for transplantation selected by said method. [Solution] The present invention provides a method for evaluating the quality of neuroretina for transplantation, comprising: extracting a part or all of a cell aggregate containing a neuroretina having an epithelial structure derived from pluripotent stem cells as a quality evaluation sample; detecting the expression of neuroretinal cell-related genes and non-neuroretinal cell-related genes in the quality evaluation sample; and determining, if the expression of neuroretinal cell-related genes is observed and the expression of non-neuroretinal cell-related genes is not observed, that (1) a neuroretina (neuroretina for transplantation) from the same cell aggregate as the cell aggregate containing a part of the quality evaluation sample, (2) a neuroretina (neuroretina for transplantation) from the same lot as the cell aggregate containing a part of the quality evaluation sample, or (3) a neuroretina (neuroretina for transplantation) from the same lot as the cell aggregate of the entire quality evaluation sample, wherein the non-neuroretinal cell-related genes include one or more genes selected from the group consisting of brain and spinal cord tissue marker genes and eyeball-related tissue marker genes.

The invention belongs to the crossing field of medical instruments, biomedical engineering, metamaterials and ultrasonic imaging, and discloses an ultrasonic tissue marker and a system thereof, the ultrasonic tissue marker comprises a first material and a second material; the second material is distributed in the first material and is arranged in an array of m rows and n columns along a distribution plane; the projection size of the second material of the ith part in any row is di, and the distance between the projection centers of the second material of the (k-1) th part and the projection centers of the second material of the kth part on the distribution plane is ak-1, k, so that (i) the distances between the projection centers are the same, and di changes along with the difference of i; or (ii) ak-1, k varies as k varies, and the projection sizes are the same as each other. By controlling the distribution condition of the second material distributed on the first material, the ultrasonic reflection band gap can be correspondingly formed by utilizing the spatial change of the projection center distance or the projection size of the second material, and the formed ultrasonic tissue marker has ultrasonic frequency domain specificity.

Ultrasound systems and methods emit broadband ultrasound through a probe to excite and detect markers in body tissue (e.g., mammary gland, lung). The returned ultrasound energy (narrow band) detected by the probe is processed to differentiate the response of the marker from other detected ultrasound. The process is fast enough to accommodate movement that is typically a handheld probe, while providing accurate positioning. The processing may include RF filtering and mixing, demodulation, and target detection by spatial or "image" processing based on the known geometry of the marker and its response characteristics. Target detection may include sigma mapping with frame-to-frame comparisons, and target best fit processing to separate speckles that best match a set of target space criteria. Optionally, nonlinearity is introduced into the ultrasound emission and used to identify the response of the marker. The marker can suspend and move in the hydrogel.

An implantable tissue marker device is provided to be placed in a soft tissue site through a surgical incision. The device can include a bioabsorbable body in the form of a spiral and defining a spheroid shape for the device, the spiral having a longitudinal axis, and turns of the spiral being spaced apart from each other in a direction along the longitudinal axis. A plurality of markers can be disposed on the body, the markers being visualizable by a radiographic imaging device. The turns of the spiral are sufficiently spaced apart to form gaps that allow soft tissue to infiltrate between the turns and to allow flexibility in the device along the longitudinal axis in the manner of a spring.

A tissue marker for insertion into a human or animal body during a surgical procedure. The tissue marker having a first marker element and at least one second marker element, the first and at least one second marker element contain a biodegradable material. According to the technical solution described the first marker element comprises a hollow body containing chitosan and the second marker element is located inside the hollow body of the first marker element.

A surgical instrument includes a housing, a shaft, an end effector assembly, a drive assembly, and a tissue sensor assembly. The end effector assembly has first and second jaws movable relative to each other between an open configuration in which the first and second jaws define a first jaw flare angle greater than a predetermined jaw flare angle and a closed configuration in which the first and second jaws define a second jaw flare angle greater than the predetermined jaw flare angle. The first jaw and the second jaw define a second jaw flare angle less than the predetermined jaw flare angle. The drive assembly includes a drive tube extending through the shaft, the drive tube configured to move the first jaw and the second jaw between an open configuration and a closed configuration. The tissue sensor assembly includes a tissue marker coupled to the drive assembly and translatable with the drive tube; and a tissue marker sensor coupled to the housing for detecting movement of the tissue marker.

The invention relates to a tissue marker for proton radiation heart injury and application of the tissue marker. The tissue marker comprises one or more of a transcription marker and a protein marker. Wherein the transcription marker comprises one or more of PIK3R5, CCR7, IL7R, CD7, CD22, CR2, CCL5 and VAV1, and the transcription marker comprises one or more of PIK3R5, CCR7, IL7R, CD7, CD22, CR2, CCL5 and VAV1; and the protein marker comprises one or more of SIRT1 and HMGB1 (High Mobility Group Box 1). According to the invention, the differential marker is used as a potential biomarker of the radioactive heart loss, and a research method for researching the radioactive heart loss by using a mouse model is provided, so that a demonstrative research is provided for multi-omics analysis of the radioactive heart loss and explanation of an action mechanism of the radioactive heart loss.

Ultrasound systems and methods transmit wideband ultrasound via a probe to excite and detect markers in bodily tissue ( e.g. , breast, lung). For example, a transmitted pulse ensemble can advantageously include pulses with different frequencies from on another. Returning ultrasound energy detected by the probe is processed via a return signal processing chain to discern the response of a marker from other detected ultrasound. The processing is sufficiently fast to accommodate movement of a typically handheld probe, while providing accurate localization. Processing can include: RF filtering and mixing, demodulation, and "image" processing based on known geometry of the marker and its response signature. Target detection can include brightness mapping, sigma mapping with frame-to-frame comparisons, and segmentation mapping. Target analysis can include ranking targets based on a set of target characterizing criteria. Optionally, a nonlinearity is introduced into the transmissions, and used in discerning the marker responses.

An implantable tissue marker device is provided to be placed in a soft tissue site through a surgical incision. The device can include a bioabsorbable body in the form of a spiral and defining a spheroid shape for the device, the spiral having a longitudinal axis, and turns of the spiral being spaced apart from each other in a direction along the longitudinal axis. A plurality of markers can be disposed on the body, the markers being visualizable by a radiographic imaging device. The turns of the spiral are sufficiently spaced apart to form gaps that allow soft tissue to infiltrate between the turns and to allow flexibility in the device along the longitudinal axis in the manner of a spring.

Processing devices and related methods are provided. The processing device includes a handpiece configured to deliver electromagnetic radiation (EMR) along an optical axis; a window disposed at an end of the handpiece and intersecting the optical axis; an optical device disposed within the handpiece; an EMR source in communication with the handpiece and configured to emit processing radiation along an optical axis through the optical device and the window; and at least one light source disposed in the housing and offset from the optical axis. The window is configured to directly contact the tissue. The optical device includes a high NA lens. The at least one light source is configured to illuminate the contacted tissue at a substantially inclined angle, and is configured to emit light having a wavelength within a variable wavelength range between about 300 nm and about 650 nm based on tissue markers in the tissue.

This invention discloses a method, apparatus, and storage medium for determining tissue marking locations. The method includes acquiring the edge contour and hardness distribution information of a target tissue, wherein the hardness distribution information characterizes the hardness at different locations within the target tissue; determining a first candidate location to be marked in the target tissue region based on the shape characteristics of the edge contour; and determining locations where the hardness exceeds a hardness threshold as a second candidate location to be marked in the target tissue region based on the hardness distribution information; and determining the target location to be marked in the target tissue region based on the first and second candidate locations. This method allows for tissue marking without manual intervention, significantly improving the accuracy and efficiency of tissue marking.

The invention relates to a microfluidic system for rapid quantitative detection of breast cancer tissue markers and a detection method, and belongs to the technical field of biology, the microfluidic system comprises an acrylic cover plate, a pressure-sensitive adhesive layer and a glass substrate; the acrylic cover plate, the pressure-sensitive adhesive layer and the glass substrate are bonded together from top to bottom, and the reaction cavity of the micro pressure-sensitive adhesive layer is filled with antibody microbeads. And the micro reaction cavity, the inlet channel and the outlet channel of the pressure-sensitive adhesive layer form a micro flow path structure. According to the invention, quantification and standardization of the whole process from a tissue sample to a molecular typing result are realized, and the qualitative / semi-quantitative dependence problem is solved; an innovative tissue protein rapid preparation method, a special microfluidic system and a data analysis process based on fluorescence quantification are integrated into a whole; the whole process thoroughly gets rid of dependence on traditional tissue slicing, dyeing and manual microscopic examination.

This invention belongs to the field of medical devices, specifically relating to a positioning and marking device for breast tumor surgery. The device includes a guide needle, a tissue marker clip, a delivery component, and a flexible outer sheath fitted over the needle. The flexible outer sheath is made of a biocompatible shape memory polymer. At body temperature, it is in a first physical state, puncturing the tissue along with the needle. Upon gentle thermal stimulation, it transforms into a second physical state, significantly reducing friction with the needle, allowing the needle to be withdrawn independently, leaving the flexible outer sheath in place within the body, forming a stable guiding channel from the body surface to the marked location. The device can also integrate an intelligent temperature control unit, achieving closed-loop regulation through temperature sensor feedback to ensure safe and effective thermal stimulation. This invention solves the intraoperative positioning problem caused by lesion shrinkage after chemotherapy, combining long-term placement safety, puncture rigidity, and placement flexibility, significantly improving the accuracy and reliability of surgical positioning.

The addition of hydrophilic and / or lipophilic antioxidants to aldehyde histological fixatives and / or to the materials for embedding the preparations allows to improve the preservation of antigenic characteristics of tissue markers and the preservation of the integrity of DNA and RNA sequences.

The inventions provided herein relate to tissue markers and uses thereof, e.g., to mark a target tissue site (e.g., a biopsy site in a breast tissue) or to produce a cell scaffold. The tissue markers described herein are designed to be resistant to fast migration (e.g., immediate migration after implantation through a needle track) and slow migration (e.g., over an extended period of time) upon implantation at a target tissue site (e.g., a biopsy site in a breast tissue), without using an adhesive. Additionally or alternatively, the tissue markers described herein can be readily detectable by at least one imaging modality, e.g., but not limited to magnetic resonance imaging, X-ray imaging, ultrasound imaging, or a combination thereof.