9 results about "Tissue markers" patented technology

The invention belongs to the crossing field of medical instruments, biomedical engineering, metamaterials and ultrasonic imaging, and discloses an ultrasonic tissue marker and a system thereof, the ultrasonic tissue marker comprises a first material and a second material; the second material is distributed in the first material and is arranged in an array of m rows and n columns along a distribution plane; the projection size of the second material of the ith part in any row is di, and the distance between the projection centers of the second material of the (k-1) th part and the projection centers of the second material of the kth part on the distribution plane is ak-1, k, so that (i) the distances between the projection centers are the same, and di changes along with the difference of i; or (ii) ak-1, k varies as k varies, and the projection sizes are the same as each other. By controlling the distribution condition of the second material distributed on the first material, the ultrasonic reflection band gap can be correspondingly formed by utilizing the spatial change of the projection center distance or the projection size of the second material, and the formed ultrasonic tissue marker has ultrasonic frequency domain specificity.

The invention relates to a tissue marker for proton radiation heart injury and application of the tissue marker. The tissue marker comprises one or more of a transcription marker and a protein marker. Wherein the transcription marker comprises one or more of PIK3R5, CCR7, IL7R, CD7, CD22, CR2, CCL5 and VAV1, and the transcription marker comprises one or more of PIK3R5, CCR7, IL7R, CD7, CD22, CR2, CCL5 and VAV1; and the protein marker comprises one or more of SIRT1 and HMGB1 (High Mobility Group Box 1). According to the invention, the differential marker is used as a potential biomarker of the radioactive heart loss, and a research method for researching the radioactive heart loss by using a mouse model is provided, so that a demonstrative research is provided for multi-omics analysis of the radioactive heart loss and explanation of an action mechanism of the radioactive heart loss.

Ultrasound systems and methods transmit wideband ultrasound via a probe to excite and detect markers in bodily tissue ( e.g. , breast, lung). For example, a transmitted pulse ensemble can advantageously include pulses with different frequencies from on another. Returning ultrasound energy detected by the probe is processed via a return signal processing chain to discern the response of a marker from other detected ultrasound. The processing is sufficiently fast to accommodate movement of a typically handheld probe, while providing accurate localization. Processing can include: RF filtering and mixing, demodulation, and "image" processing based on known geometry of the marker and its response signature. Target detection can include brightness mapping, sigma mapping with frame-to-frame comparisons, and segmentation mapping. Target analysis can include ranking targets based on a set of target characterizing criteria. Optionally, a nonlinearity is introduced into the transmissions, and used in discerning the marker responses.

Processing devices and related methods are provided. The processing device includes a handpiece configured to deliver electromagnetic radiation (EMR) along an optical axis; a window disposed at an end of the handpiece and intersecting the optical axis; an optical device disposed within the handpiece; an EMR source in communication with the handpiece and configured to emit processing radiation along an optical axis through the optical device and the window; and at least one light source disposed in the housing and offset from the optical axis. The window is configured to directly contact the tissue. The optical device includes a high NA lens. The at least one light source is configured to illuminate the contacted tissue at a substantially inclined angle, and is configured to emit light having a wavelength within a variable wavelength range between about 300 nm and about 650 nm based on tissue markers in the tissue.

This invention discloses a method, apparatus, and storage medium for determining tissue marking locations. The method includes acquiring the edge contour and hardness distribution information of a target tissue, wherein the hardness distribution information characterizes the hardness at different locations within the target tissue; determining a first candidate location to be marked in the target tissue region based on the shape characteristics of the edge contour; and determining locations where the hardness exceeds a hardness threshold as a second candidate location to be marked in the target tissue region based on the hardness distribution information; and determining the target location to be marked in the target tissue region based on the first and second candidate locations. This method allows for tissue marking without manual intervention, significantly improving the accuracy and efficiency of tissue marking.

This invention belongs to the field of medical devices, specifically relating to a positioning and marking device for breast tumor surgery. The device includes a guide needle, a tissue marker clip, a delivery component, and a flexible outer sheath fitted over the needle. The flexible outer sheath is made of a biocompatible shape memory polymer. At body temperature, it is in a first physical state, puncturing the tissue along with the needle. Upon gentle thermal stimulation, it transforms into a second physical state, significantly reducing friction with the needle, allowing the needle to be withdrawn independently, leaving the flexible outer sheath in place within the body, forming a stable guiding channel from the body surface to the marked location. The device can also integrate an intelligent temperature control unit, achieving closed-loop regulation through temperature sensor feedback to ensure safe and effective thermal stimulation. This invention solves the intraoperative positioning problem caused by lesion shrinkage after chemotherapy, combining long-term placement safety, puncture rigidity, and placement flexibility, significantly improving the accuracy and reliability of surgical positioning.

The inventions provided herein relate to tissue markers and uses thereof, e.g., to mark a target tissue site (e.g., a biopsy site in a breast tissue) or to produce a cell scaffold. The tissue markers described herein are designed to be resistant to fast migration (e.g., immediate migration after implantation through a needle track) and slow migration (e.g., over an extended period of time) upon implantation at a target tissue site (e.g., a biopsy site in a breast tissue), without using an adhesive. Additionally or alternatively, the tissue markers described herein can be readily detectable by at least one imaging modality, e.g., but not limited to magnetic resonance imaging, X-ray imaging, ultrasound imaging, or a combination thereof.