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59 results about "Tissue markers" patented technology
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Breast tissue markers are a common finding in breast radiology. These are typically inserted following percutaneous biopsy, either under ultrasound or sterotactic guidance. They can be invaluable in identifying known benign areas or shrinking/treated malignant lesions on follow up imaging.
Pancreatic cancer associated antigen, antibody thereto, and diagnostic and treatment methods
The present invention is directed to an antigen found on the surface of rat and human pancreatic cancer cells and provides antibodies of high specificity and selectivity to this antigen as well as hybridomas secreting the subject antibodies. Methods for both the diagnosis and treatment of pancreatic cancer are also provided. This tissue marker of pancreatic adenocarcinoma, an approximately 43.5 kD surface membrane protein designated PaCa-Ag1, is completely unexpressed in normal pancreas but abundantly expressed in pancreatic carcinoma cells. Moreover, a soluble form of PaCa-Ag1 exists, having a molecular weight about 36 to about 38 kD, that is readily identified in sera and other body fluids of pancreatic cancer patients, using a subject antibody.
Owner:THE RES FOUND OF STATE UNIV OF NEW YORK
Devices and methods for tissue severing and removal
InactiveUS20040199159A1Surgical needlesVaccination/ovulation diagnosticsAnatomical structuresTissue Collection
The present invention relates to devices and methods that enhance the accuracy of lesion excision, through severing, capturing and removal of a lesion within soft tissue. Furthermore, the present invention relates to devices and methods for the excision of breast tissue based on the internal anatomy of the breast gland. A tissue severing device generally comprises a guide having at least one lumen and a cutting tool contained within the lumen. The cutting tool is capable of extending from the lumen and forming an adjustable cutting loop. The cutting loop may be widened or narrowed and the angle between the loop extension axis and the guide axis may be varied. Optional tissue marker and tissue collector may additionally be provided. A method for excising a mass of tissue from a patient is also provided. The device and method are particularly useful for excising a lesion from a human breast, e.g., through the excision and removal of a part of a breast lobe, an entire breast lobe or a breast lobe plus surrounding adjacent tissue.
Owner:ACUEITY HEALTHCARE
Intraluminal tissue markers
Methods and devices are provided for marking tissue to be subsequently located for removal from a body or for other examination. In general, a marker is provided that can be delivered to a target tissue. In one embodiment, the marker can include a solution having a visual marking component and a palpably identifiable tactile marking component. The marker can remain in the body and be subsequently visually and / or palpably identified to locate the target tissue.
Owner:ETHICON ENDO SURGERY INC
Devices and methods for tissue severing and removal
InactiveUS6743228B2Surgical needlesVaccination/ovulation diagnosticsAnatomical structuresTissue Collection
Owner:ACUEITY HEALTHCARE
Biodegradable polymer for marking tissue and sealing tracts
ActiveUS7329414B2Increase flexibilityModulus of elasticitySurgical adhesivesVaccination/ovulation diagnosticsMarkers tissueSealant
A tissue marker formed of a biodegradable polymer having drug-delivery capabilities is combined with a sealant that encapsulates the tissue marker and which serves to help anchor the tissue marker against migration. The sealant is delivered to a site in dehydrated form and moisture inherent in tissue at the site expands the sealant. The expanded sealant is formed of a hydrogel and is therefore more compatible to the surrounding tissue than the material of the tissue marker. The sealant and the tissue marker are both bioabsorbed over time.
Owner:MED GENESIS LLC
Marker delivery system with obturator
A marker delivery device is described which has an obturator with an elongated shaft, an inner lumen, a proximal end, and a substantially sealed distal end. One or more tissue markers are deployed within the inner lumen of the elongated shaft of the obturator. Preferably, the tissue marker(s) is disposed within an inner lumen of a marker delivery tube which is disposed within the inner lumen of the elongated shaft of the obturator. The marker delivery tube has an opening for discharging the tissue markers into a body (e.g. biopsy) cavity. The distal tip of the marker delivery tube is configured to penetrate the substantially sealed distal end of the obturator so that tissue markers can be delivered while the obturator is in place within the body. Preferably, the obturator includes a detectable element capable of producing a relatively significant image signature during MRI.
Owner:SENORX
Anatomical location markers and methods of use in positioning sheet-like materials during surgery
ActiveUS20130172920A1Precise positioningPrecise deploymentSurgical needlesDiagnostic markersDistal portionDelivery system
A tissue marker assembly which can be useful with an implant delivery system for delivering a sheet-like implant is disclosed. The tissue marker assembly can include a delivery sleeve with a tissue marker slidably disposed within a lumen therethrough. A proximal handle can be coupled to the tissue marker and delivery sleeve, having a first part and a second part. The second part of the proximal handle can be releasably attached to the tissue marker proximal end so that the second part can be removed to allow the delivery sleeve to be removed proximally over the tissue marker after it is affixed to tissue. The distal portion of the marker can include a plurality of longitudinally extending arms when unconstrained project outward from the shaft to retain the marker's position in tissue.
Owner:ROTATION MEDICAL
Marker device for X-ray, ultrasound and MR imaging
InactiveUS20060293581A1Sharp contrastEasily introduced into tissueUltrasonic/sonic/infrasonic diagnosticsPowder deliveryDiagnostic Radiology ModalityMicrosphere
An imaging marker comprised of glass and iron-containing aluminum microspheres in a gel matrix which shows uniformly good contrast with MR, US and X-Ray imaging. The marker is small and can be easily introduced into tissue through a 12-gauge biopsy needle. The concentration of glass microspheres and the size dictate the contrast for US imaging. The contrast seen in MRI resulting from susceptibility losses is dictated by the number of iron-containing aluminum microspheres; while the artifact of the marker also depends on its shape, orientation and echo time. By optimizing the size, iron concentration and gel binding, an implantable tissue marker is created which is clearly visible with all three imaging modalities.
Owner:SUNNYBROOK & WOMENS COLLEGE HEALTH SCI CENT
Biopsy marker delivery system
InactiveUS20080188768A1Surgical needlesVaccination/ovulation diagnosticsBiomedical engineeringDelivery system
A method for marking a biopsy cavity using a delivery device is provided. The delivery device may include a tube having a lumen and a side exit port communicating with the lumen, a rod slideably located in the lumen of the tube, and a tissue marker removably located at the distal end of the tube. The tissue marker may include a bioabsorbable material and a radiopaque marker. The radiopaque marker may be a metal band, a metal wire, or identified with a number, letter, symbol, or combination thereof.
Owner:DEVICOR MEDICAL PROD
Tissue marker and method and apparatus for deploying the marker
The subject invention pertains to a tissue marker. The subject invention also relates to methods and apparatus for deploying a tissue marker. In a specific embodiment, the subject marker is magnetic resonance imaging (MRI) compatible. In additional embodiment, various components of the subject marker deploying apparatus are MRI compatible. A specific marker in accordance with the subject invention is flexible such that the marker has an equilibrium shape, which the marker will have when deployed in tissue to be marked, and an elongated shape, which the marker can be bent into to be inserted into a marker needle.
Owner:WINKEL AXEL
Anatomical location markers and methods of use in positioning sheet-like materials during surgery
ActiveUS20130245707A1Accurately positioning and deploying and deliveringEasy to insertDiagnostic markersJoint implantsDistal portionProximal point
A tissue marker assembly which can be useful with an implant delivery system for delivering a sheet-like implant is disclosed. The tissue marker assembly can include a delivery sleeve with a tissue marker slidably disposed within a lumen therethrough. A proximal handle can be coupled to the tissue marker and delivery sleeve, having a first part and a second part. The second part of the proximal handle can be releasably attached to the tissue marker proximal end so that the second part can be removed to allow the delivery sleeve to be removed proximally over the tissue marker after it is affixed to tissue. The distal portion of the marker can include a plurality of longitudinally extending arms when unconstrained project outward from the shaft to retain the marker's position in tissue.
Owner:ROTATION MEDICAL
Devices and methods for tissue severing and removal
InactiveUS20030163129A1Surgical needlesVaccination/ovulation diagnosticsAnatomical structuresTissue Collection
The present invention relates to devices and methods that enhance the accuracy of lesion excision, through severing, capturing and removal of a lesion within soft tissue. Furthermore, the present invention relates to devices and methods for the excision of breast tissue based on the internal anatomy of the breast gland. A tissue severing device generally comprises a guide having at least one lumen and a cutting tool contained within the lumen. The cutting tool is capable of extending from the lumen and forming an adjustable cutting loop. The cutting loop may be widened or narrowed and the angle between the loop extension axis and the guide axis may be varied. Optional tissue marker and tissue collector may additionally be provided. A method for excising a mass of tissue from a patient is also provided. The device and method are particularly useful for excising a lesion from a human breast, e.g., through the excision and removal of a part of a breast lobe, an entire breast lobe or a breast lobe plus surrounding adjacent tissue.
Owner:ACUEITY HEALTHCARE
Tissue marker for multimodality radiographic imaging
ActiveUS7702378B2Increase intensityImprove featuresUltrasonic/sonic/infrasonic diagnosticsMagnetic measurementsUltrasound imagingDiagnostic Radiology Modality
An implantable tissue marker incorporates a contrast agent sealed within a chamber in a container formed from a solid material. The contrast agent is selected to produce a change, such as an increase, in signal intensity under magnetic resonance imaging (MRI). An additional contrast agent may also be sealed within the chamber to provide visibility under another imaging modality, such as computed tomographic (CT) imaging or ultrasound imaging.
Owner:BREAST MED
Biodegradable polymer for marking tissue and sealing tracts
A tissue marker formed of a biodegradable polymer having drug-delivery capabilities is combined with a sealant that encapsulates the tissue marker and which serves to help anchor the tissue marker against migration. The sealant is delivered to a site in dehydrated form and moisture inherent in tissue at the site expands the sealant. The expanded sealant is formed of a hydrogel and is therefore more compatible to the surrounding tissue than the material of the tissue marker. The sealant and the tissue marker are both bioabsorbed over time.
Owner:BIOPSY SCI LLC
Marker delivery system with obturator
ActiveUS7945307B2Prevents and minimizes backflowPreventing and minimizing entrySurgical needlesMedical devicesDelivery systemBiopsy
A marker delivery device is described which has an obturator with an elongated shaft, an inner lumen, a proximal end, and a substantially sealed distal end. One or more tissue markers are deployed within the inner lumen of the elongated shaft of the obturator. Preferably, the tissue marker(s) is disposed within an inner lumen of a marker delivery tube which is disposed within the inner lumen of the elongated shaft of the obturator. The marker delivery tube has an opening for discharging the tissue markers into a body (e.g. biopsy) cavity. The distal tip of the marker delivery tube is configured to penetrate the substantially sealed distal end of the obturator so that tissue markers can be delivered while the obturator is in place within the body. Preferably, the obturator includes a detectable element capable of producing a relatively significant image signature during MRI.
Owner:SENORX
Anatomical location markers and methods of use in positioning sheet-like materials during surgery
ActiveUS9204940B2Accurately positioning and deploying and deliveringEasy to insertDiagnostic markersOsteosynthesis devicesDistal portionDelivery system
A tissue marker assembly which can be useful with an implant delivery system for delivering a sheet-like implant is disclosed. The tissue marker assembly can include a delivery sleeve with a tissue marker slidably disposed within a lumen therethrough. A proximal handle can be coupled to the tissue marker and delivery sleeve, having a first part and a second part. The second part of the proximal handle can be releasably attached to the tissue marker proximal end so that the second part can be removed to allow the delivery sleeve to be removed proximally over the tissue marker after it is affixed to tissue. The distal portion of the marker can include a plurality of longitudinally extending arms when unconstrained project outward from the shaft to retain the marker's position in tissue.
Owner:ROTATION MEDICAL
Transluminal tissue markers
Methods and devices are provided for marking tissue to be subsequently located for removal from a body or for other examination. In general, a marker is provided that can be delivered through a tissue wall proximate to tissue desirable for marking. The marker can be movable between a non-deployed or unexpanded position, in which the marker is configured to be delivered through a relatively small diameter passageway, to an expanded, balloon-like position in which the marker is configured to engage opposed sides of a tissue wall proximate to the desired tissue. The marker can remain disposed in the body in its expanded position and be subsequently palpably identified and / or visually identified to locate the desired tissue.
Owner:ETHICON ENDO SURGERY INC
Tissue marker for multimodality radiographic imaging
ActiveUS20070110665A1Good visualization characteristicIncrease in signal intensityUltrasonic/sonic/infrasonic diagnosticsMagnetic measurementsUltrasound imagingVisibility
An implantable tissue marker incorporates a contrast agent sealed within a chamber in a container formed from a solid material. The contrast agent is selected to produce a change, such as an increase, in signal intensity under magnetic resonance imaging (MRI). An additional contrast agent may also be sealed within the chamber to provide visibility under another imaging modality, such as computed tomographic (CT) imaging or ultrasound imaging.
Owner:BREAST MED
Marker delivery device with obturator
InactiveUS20110184449A1Prevents and minimizes backflowPreventing and minimizing entrySurgical needlesDiagnostic markersBiomedical engineeringTissue markers
A marker delivery device includes an obturator having an elongated shaft, an internal lumen, a proximal end, and a substantially sealed distal end. The substantially sealed distal end is formed of a penetrable membrane. A marker delivery tube is configured to be slidably disposed within the internal lumen of the obturator. The marker delivery tube has a marker delivery lumen, a proximal end, and a distal tip. The marker delivery lumen is configured to contain one or more tissue markers. The distal tip is configured to puncture the penetrable membrane of the substantially sealed distal end of the obturator to form a passage through which the distal tip extends to facilitate delivery of the one or more tissue markers.
Owner:SENORX
Marker delivery device for tissue marker placement
ActiveUS20110028836A1Easy to bendEasy to take backSurgeryDiagnostic markersBiomedical engineeringTissue markers
A marker delivery device is configured for deploying a tissue marker. The marker delivery device includes a handle having a chamber, and a cannula. According to one aspect, the cannula has a flexible portion formed by a slot arrangement having of a plurality of spaced-apart substantially parallel peripheral slots extending through the side wall of the cannula to the lumen. A marker introducer rod is movably disposed in the lumen of the cannula for deploying the mark, and has a flexible region that corresponds to the flexible portion of the cannula. According to another aspect, a retraction mechanism is mounted to the handle and is configured to facilitate a complete retraction of both the cannula and the marker introducer rod into the chamber of the housing of the handle upon an actuation of the retraction mechanism.
Owner:CR BARD INC
X-ray developing thermotropic hydrogel and preparation method thereof
ActiveCN104645356APossesses thermally induced gelation propertiesGood injectabilityAerosol deliverySurgeryTissue repairEmbolization Agent
The invention belongs to the technical field of medical polymer materials and in particular relates to X ray developing thermotropic hydrogel and a preparation method thereof. The X ray developing thermotropic hydrogel comprises an iodine-containing amphiphilic block copolymer and a solvent, wherein the iodine-containing amphiphilic block copolymer is obtained by bonding an iodine-containing micromolecule and an amphiphilic block copolymer by virtue of a covalent bond, and thermotropic gelatinization phase transformation can be carried out on a water system of the X ray developing thermotropic hydrogel along with temperature increase. The thermotropic hydrogel can be implanted under the skin and implanted into an abdominal cavity, an articular cavity and other specific parts of a human body in a mode of injection, and in situ formed hydrogel has good X ray developing performance, clear positioning and long-term tracing observation can be carried out on the hydrogel by adopting an X ray radiography technique. The thermotropic hydrogel also can serve as a medicine controlled release carrier, a tissue repairing support, a blood vascular embolization agent, a tissue marker and the like and can be used for realizing integration of diagnosis and treatment.
Owner:FUDAN UNIV
Biopsy tissue marker
A biopsy site marker is disclosed. The biopsy site marker includes a first marker element and a second marker element. The first marker element is configured for detection by a first imaging modality. The second marker element is configured for detection by a second imaging modality different from the first imaging modality. The second marker element may be a non-absorbable wire having a predetermined shape and is substantially engaged with the first marker element.
Owner:CR BARD INC
Implants and biodegradable tissue markers
ActiveUS9669117B2Precise positioningImprove visualizationPowder deliverySurgeryBiomedical engineeringImplant material
Owner:INCEPT LLC
Methods and kits for identifying ductal orifices in a nipple
InactiveUS6455027B1Enhances distinguishing an orifice from surrounding tissueIncrease awarenessUltrasonic/sonic/infrasonic diagnosticsLuminescence/biological staining preparationVisibilityCatheter
Methods, kits, and apparatus for locating, labelling, and accessing breast ducts are described. An orifice to one or more ductal networks is marked to enhance visibility. In a first embodiment, the orifice is labelled using a specific binding substance, typically an antibody, specific for a tissue marker present on the orifice. Exemplary tissue markers include those present on the ductal epithelium, such as cytokeratins, including cytokeratin 8 and cytokeratin 18; cadhedrins, such as E cadhedrin; and epithelial membrane antigens. In a second embodiment, a dye is injected into the base of the nipple and preferentially accumulates at at least some of the orifices. Other marking techniques are also described. Marking of the ductal orifices permits reliable identification and access to each of the multiple ductal networks which may be present in an individual breast.
Owner:RGT UNIV OF CALIFORNIA
Biopsy Tissue Marker
A biopsy site marker is disclosed. The biopsy site marker includes a first marker element and a second marker element. The first marker element is configured for detection by a first imaging modality. The second marker element is configured for detection by a second imaging modality different from the first imaging modality. The second marker element may be a non-absorbable wire having a predetermined shape and is substantially engaged with the first marker element.
Owner:CR BARD INC
Marker delivery device for tissue marker placement
A marker delivery device is configured for deploying a tissue marker. The marker delivery device includes a handle having a chamber, and a cannula. According to one aspect, the cannula has a flexible portion formed by a slot arrangement having of a plurality of spaced-apart substantially parallel peripheral slots extending through the side wall of the cannula to the lumen. A marker introducer rod is movably disposed in the lumen of the cannula for deploying the mark, and has a flexible region that corresponds to the flexible portion of the cannula. According to another aspect, a retraction mechanism is mounted to the handle and is configured to facilitate a complete retraction of both the cannula and the marker introducer rod into the chamber of the housing of the handle upon an actuation of the retraction mechanism.
Owner:CR BARD INC
Risk prediction of tissue infarction
The present invention relates to a method for generating a risk map indicating predicted voxel-by-voxel probability of tissue infarction for a set of voxels, the method comprising the steps of, receiving for each voxel a first value (x) corresponding to a set of tissue marker values and generating the risk map, using a statistical model based on data from a group of subjects, and a stochastic variable, wherein the statistical model also comprises a second value (zi), being based on the stochastic variable, such as the second value modelling non-measured values. The invention may be seen as advantageous since it acknowledges subject variability in probability of tissue infarction on a voxel-by-voxel basis by taking non-measured values into account, which in turn may enable providing more reliable estimates of probability of infarction.
Owner:AARHUS UNIV
Tissue marker for multimodality radiographic imaging
ActiveUS20100287887A1Increase intensityImprove featuresUltrasonic/sonic/infrasonic diagnosticsMagnetic measurementsDiagnostic Radiology ModalityUltrasound imaging
An implantable tissue marker incorporates a contrast agent sealed within a chamber in a container formed from a solid material. The contrast agent is selected to produce a change, such as an increase, in signal intensity under magnetic resonance imaging (MRI). An additional contrast agent may also be sealed within the chamber to provide visibility under another imaging modality, such as computed tomographic (CT) imaging or ultrasound imaging.
Owner:BREAST MED
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