32 results about "Diphenyl phosphite" patented technology

The invention relates to a 1, 1'-ferrocene perfluoroalkyl phosphine nitrogen ligand as well as a preparation method and an application thereof. The preparation method of the 1, 1'-ferrocene perfluoroalkyl phosphine nitrogen ligand comprises the following steps: (1) reacting oxazoline bromoferrocene with a butyl lithium compound in an organic solvent under the condition of existence of an additive; (2) mixing reaction liquid obtained in the step (1) with triphenyl phosphite; and (3) in the solvent, reacting an isodecyl diphenyl phosphite derivative obtained in the step (2) and cesium fluoride with TMSCnF2n+1. The invention also relates to the application of the ligand in an asymmetric allyl displacement reaction catalyzed by metallic palladium. The ligand provided by the invention can be used for catalyzing the allyl displacement reaction of single substituted allyl carbonic ester in a high domain selectivity and high enantioselectivity manner. The synthetic method is simple, mild in conditions, high in yield, convenient in purification and suitable for industrial production; starting materials are low in cost and easy to obtain.

The invention provides a process method for synthesizing tenofovir alafenamide intermediate (R)-9-[(2-phenoxyphosphate methoxy)propyl]adenine, using (R)-9 -(2-phosphoryl methoxypropyl)adenine is a starting material, in the presence of a suitable solvent M, it is prepared by reacting with diphenyl phosphite / or with diphenyl phosphite and phenol. The solvent M is selected from pyridine, 2,6-lutidine, triethylamine, diisopropylethylamine; preferably pyridine. The beneficial effect of the method is that: in the preparation process of the compound of formula I, diphenyl phosphite is used to carry out the esterification reaction, and the yield and the purity are greatly improved. % or more, the production cost is greatly reduced; and the method is simple in operation, short in reaction time, high in production efficiency, and easy to scale up; in addition, the method has simple post-treatment process and little environmental pollution, and is suitable for industrial production.

The invention discloses a preparation method of diphenyl phosphite. In the method, phosphorus trichloride, phenol and water are used as raw materials. After the reaction is completed, the diphenyl phosphite is obtained by depressurizing and introducing nitrogen gas to eliminate by-product hydrogen chloride. The method does not produce phenol as a by-product, solves the problems of increased cost and waste liquid treatment caused by repeated recovery of phenol, simplifies the production process, improves production efficiency, and does not need to use a large amount of phosphorous acid in the production process, greatly reducing production Risk, reduced production cost and environmental cost, suitable for industrial production.