107 results about "Lymphatic oedema" patented technology

The invention is applicable to the technical field of biological medicines, and provides application of Paquinimod in preparation of a medicine for treating secondary lymphedema. According to the application, the S100A8 / A9 dimer small-molecule inhibitor Paquinimod is used for treating mice with lymphedema, and a result shows that the Paquinimod can be used for remarkably inhibiting secretion of inflammatory factors of the model mice, effectively relieving the edema condition and inhibiting activation of an S100A8 / A9-TLR4-CCL2 signal channel. Therefore, the inhibitor Paquinimod of the S100A8 / A9-TLR4 signal channel is applied to preparation of the medicine for treating the secondary lymphedema (SL), a new thought and a new method are developed for treatment of the SL, and the problem that the SL lacks an effective treatment means is effectively solved.

The invention relates to the technical field of medical data management and analysis, in particular to a lymphedema treatment monitoring data management method and system. Comprising the following steps: synchronously acquiring bioelectrical impedance, tissue thermodynamic characteristics and subcutaneous tissue morphological data of a patient through multi-modal data acquisition equipment; transmitting the data to a cloud processing platform in a distributed manner, and generating a three-dimensional illness state assessment map containing edema quantitative indexes through a machine learning assessment model; generating a personalized treatment strategy adjustment scheme with a confidence score based on dynamic comparison between the current evaluation map and historical data; feeding back the evaluation map and the adjustment scheme to the medical staff through the interaction terminal, and receiving a clinical correction instruction; according to the method, on the premise of strictly protecting patient data privacy, cross-mechanism multi-modal knowledge sharing can be realized, and the contradiction between a data island and a model effect is solved.

The invention provides a remote monitoring method and system for lymphedema pressure treatment of a patient at home, and relates to the field of lymphedema pressure treatment. The remote monitoring system based on the lymphedema pressure treatment of the household patient comprises an intelligent tubular bandage, a multifunctional sensor module is embedded in the inner layer of the intelligent tubular bandage, and the intelligent tubular bandage comprises an ultrathin pressure sensor, a human body composition sensor, a skin texture monitor, a temperature sensor and a humidity sensor and is used for comprehensively monitoring various physiological parameters wound on limbs of the patient. Through the design of the multifunctional sensor module and the flexible circuit embedded in the intelligent tubular bandage, the accuracy and sensitivity of monitoring physiological parameters of a patient by the system are remarkably improved, the flexible circuit can be adaptively adjusted to adapt to the shape and movement of limbs of the patient, measurement errors caused by movement of the bandage or movement of the patient are reduced, and the measurement accuracy is improved. And the stability of data acquisition is ensured.

This can enhance the effects of supporting the pelvic floor muscles, preventing pelvic organ prolapse, and improving lymphatic flow, while also providing a soft feel when worn. The pelvic floor muscle support garment 10 of the present invention is formed from knitted fabric, and the crotch portion 13 has a three-layer structure including an outer knitted fabric 131, an inner knitted fabric 132, and an intermediate layer 133 therebetween, with the intermediate layer 133 having a predetermined thickness forming an annular bulge 134. As it is the inner knitted fabric 132 that comes into contact with the periphery of the female external genitalia, it feels soft against the skin, and the annular bulge 134 has high cushioning properties, so it is possible to increase the pressure on the periphery of the external genitalia while relieving localized pressure. This promotes lymphatic flow, further enhancing the preventive effect against lymphedema, etc.

The invention discloses a lymphedema home supervision method and related equipment. The method comprises the steps that the circumference data of an affected limb of a patient are obtained through a monitoring ring, the monitoring ring comprises a wrist strap with the adjustable length, and the wrist strap can stretch out or retract in the adjustable position; under the condition that it is determined that the monitoring ring retracts to the proper length, the circumference diameter and biological resistivity data of the affected limb of the patient at the wearing position of the monitoring ring are obtained; and analyzing the lymphedema condition of the affected limb of the patient based on the circumference data and the biological resistivity data of the affected limb of the patient. The method can solve the problems that although a current common home monitoring method such as a flexible rule for measuring the limb circumference is convenient, the influence of human factors is large, and high precision is difficult to guarantee. And although a clinically used body fluid composition monitoring instrument is accurate, the equipment is expensive and is not suitable for being used by the patient at home, so that the patient cannot conveniently and stably carry out self-monitoring for a long time at home.

The invention provides an external traditional Chinese medicine preparation for lymphedema, and relates to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from astragalus membranaceus, cassia twig, poria cocos, akebiaquinata, ligusticum wallichii, salvia miltiorrhiza, radix bupleuri, scutellaria baicalensis, lalang grass rhizome and herba lycopi, and all the medicines are combined to jointly achieve the effects of tonifying qi, activating blood, inducing diuresis, soothing liver-qi stagnation and clearing away heat and toxic materials. The traditional Chinese medicine preparation has obvious edema eliminating and anti-inflammatory effects on lymphedema model mice, and the treatment effect is remarkable. Meanwhile, the traditional Chinese medicine preparation for external treatment of lymphedema in traditional Chinese medicine provided by the invention can remarkably improve clinical symptoms of a patient, relieve pain of the patient, help the patient recover a functional state, reduce the level of inflammatory factors, promote edema absorption of the patient and remarkably relieve the lymphedema condition of an affected limb, and the curative effect is remarkable.

Lymphedema is characterized by the accumulation of protein-rich interstitial fluid, lipids and a significant inflammatory cell infiltrate in the limb. It causes a significant morbidity and is a common disabling disease affecting more than 250 million people worldwide, however there is no curative treatment for lymphedema. Here, the inventors found that dermolipectomies from patient with lymphedema exhibit inflamed gene expression profile compared to normal arm on same patient. After lipidomic analysis, the inventors identified severe decrease in arachidonic acid-derived lipid mediators generated by the 15-lipoxygenase (15-LOX) in lymphedematous arms. Using a mouse model of lymphedema, they reproduced the etiology of the human pathology including the loss of specialized pro-resolving lipid mediators that play essential roles in resolution of inflammation. This was associated with a lack of regulatory T cells (Treg) recruitment in the injured limb adipose tissue. Importantly, the inventors identified the lymphatic endothelial 15-LOX was responsible for the chemoattraction and transendothelial migration of Tregs. These results were confirmed by an aggravation of lymphedema and deterioration of the lymphatic network in an original transgenic mouse model in which ALOX15 gene is selectively deleted in the lymphatic system. Importantly, this was reversed by the injection of 15-LOX expressing lentivectors. These results provide evidence that lymphatic lipoxygenase may represent a novel therapeutic target for lymphedema by serving as a mediator of Treg invasion into lymphedematous adipose tissue.

The present invention provides a portable lymphedema auxiliary therapeutic device, which relates to the technical field of nursing equipment, and comprises: a control unit, a positioning unit, an auxiliary therapeutic unit A and an auxiliary therapeutic unit B; the positioning unit is installed on the control unit, and the positioning unit is used to position the control unit; the auxiliary therapeutic unit A is installed at the left end of the control unit, and the auxiliary therapeutic unit A is used for rolling massage therapy, and the auxiliary therapeutic unit A is also used for tapping massage therapy; the auxiliary therapeutic unit B is installed at the left end of the control unit, and the auxiliary therapeutic unit B is located inside the auxiliary therapeutic unit A, and the auxiliary therapeutic unit B is used for vibration massage therapy; the present invention rotates the control handle B forward or reversely by 135 degrees, thereby reducing the overall length of the present invention and making it more convenient to carry; and solves the problem that the overall length cannot be reduced when carrying due to the generally integrated structure, resulting in a longer space being occupied when carrying.

The invention discloses a universal lymphedema measuring scale for upper and lower limbs, relates to the technical field of medical measuring instruments, and provides the following scheme: the universal lymphedema measuring scale comprises a pedal plate for a detector to step on and fix; the leg detection mechanism is arranged at the top of the pedal plate and used for detecting lymphedema of the lower limbs of a detector, and the leg detection mechanism comprises a height measuring rod; the balance plate is fixed at the top of the height measuring rod; and the arm detection mechanism is arranged on the balance plate and is used for performing upper limb lymphedema detection on the detected person. The device can accurately measure the lymphedema degree of the upper and lower limbs, has the advantages of simplicity and convenience in operation, reliable measurement result, high practicability and the like, can be widely applied to the medical field, and solves the problems of non-uniform measurement, high randomness, nonstandard operation and the like in an existing measurement mode; and a reliable measuring tool is provided for diagnosis and treatment effect evaluation of lymphedema.

A limb circumference detection device includes a wire-pulling module, a first measurement module, and a second measurement module. The wire-pulling module is disposed around the limb in a surrounding manner. The first measurement module is arranged on the wire-pulling module, and the second measurement module is connected to the wire-pulling module. The first measurement module moves along the long axis direction of the limb and simultaneously measures the length of the limb. When the second measurement module moves along the long axis direction of the limb, the first measurement module synchronously measures the length of the wire-pulling module surrounding the limb, thereby continuously detecting the correlation between the limb length and the circumference. Two sets or even more than two sets of the wire-pulling modules of the detection device can be used in parallel. When two sets of wire-pulling modules are used in parallel, they can be used to monitor the change in limb softness, that is, compliance. When multiple sets of wire-pulling modules are used in parallel, they can be used for the treatment of limb edema.

Processing generated sensor data of a lymphedema device may include identifying use of the lymphedema device corresponding to a user. Sensor data associated with the user's identified use of the lymphedema device may be generated. At least some of the generated sensor data may comprise use data associated with a duration of use of the lymphedema device by the user. A protocol associated with use of the lymphedema device may be processed. The generated use data and the protocol associated with use of the lymphedema device may be correlated. Based on correlating the generated use data and the protocol, an alert associated with the generated use data and the protocol may be generated.

This invention relates to a method for calculating and correcting the volume of a limb with lymphedema. The method involves acquiring the outer contour data of the limb with lymphedema under a first and second standard measurement position, and dividing the limb into segments along its length with equal intervals to obtain two sets of corresponding volume segments. The volume of each corresponding segment is calculated, and the volume difference for the same segment number is determined. The volume segment whose absolute value of the volume difference is greater than a preset threshold is identified as the target volume segment. Based on the correspondence of the local volume distribution of the target volume segment in the two sets of volume segments, the volume difference is determined to be either a solid increment or a positional drift increment. Using the volume of each volume segment under the first standard measurement position as a benchmark, the solid increment is retained in the target volume segment, and the positional drift increment is corrected. The volumes of each volume segment after correction are summed to obtain the corrected volume of the limb with lymphedema.

1. Name of the designed product: skin pad (lymphedema). 2. Use of the designed product: skin pad for lymphedema. 3. Design points of the designed product: in shape. 4. Picture or photo best indicating the design points: perspective view.

1. Name of the designed product: measuring instrument (lymphedema). 2. Use of the designed product: for measuring lymphedema. 3. Design points of the designed product: in shape. 4. Picture or photo best indicating the design points: perspective view.

The invention relates to the technical field of disease screening, and discloses a big data-based lymphedema disease screening system which overcomes the defects of singleness, subjectivity and low efficiency of a traditional screening means by integrating multi-source data, optimizing a processing flow, accurately calculating a screening index and automatically generating an analysis result. According to the method, the accuracy, efficiency and operability of screening are remarkably improved, doctors are helped to quickly identify high-risk patients, meanwhile, the dependence of the patients on expensive detection means is reduced, optimal configuration of medical resources is achieved, comprehensive and reliable technical support is provided for early screening and intervention of lymphedema, and through multi-dimensional collection of patient information, the screening accuracy, efficiency and operability are improved. High-quality input is provided for intelligent calculation and analysis, operation of subsequent modules is more efficient and accurate, high adaptability of data in the screening process is guaranteed through the targeted design, and the problems of misdiagnosis and missed diagnosis caused by data incompleteness or deviation are solved.

The utility model provides a scrotum support for a detumescence lymphatic pad of a male lymphedema patient, which relates to the technical field of medical tools and comprises a waistband, connecting bands and a support body, the connecting bands are connected to two sides of the front end of the waistband, and the support body is connected below the connecting bands; the support body is in a concave shape and comprises outer screen cloth and a lymph drainage pad, the lymph drainage pad is arranged on the inner side of the outer screen cloth, multiple sets of protruding particles are arranged and distributed on the inner side of the lymph drainage pad, and an adjusting piece is arranged on the outer side of the outer screen cloth; the waist support is tied on the waist through the waistband and connected with the support body through the connecting belt for limiting, the support body is prevented from falling off, the support body acts on the hypogastrium and scrotum lymphedema area of a male patient, and through the concave lymphatic drainage pad and the convex particles distributed in an arrayed mode, lymphatic backflow is promoted, and the problem of lymphadema fibrosis is solved. The product adapts to the structure requirement of male external genitalia, and the treatment quality is improved.

The invention discloses an electrical stimulation lymphedema rehabilitation device, and relates to the technical field of lymphedema rehabilitation, and the device comprises a housing, and also comprises an electrical stimulation mechanism which is installed at the top of the housing and comprises a plurality of electrode plates; the limb supporting mechanism is installed on the two sides of the shell and comprises a first lantern ring and a second lantern ring; the multi-section massage mechanism is installed in the shell and comprises a plurality of air bags, and one side of each air bag is communicated with an electromagnetic valve; the uniform pressing mechanism is connected with the multi-section massage mechanism and comprises a downward moving anti-sticking mechanism and a translation switching mechanism; the electrical stimulation mechanism further comprises a controller fixed to the top of the shell, and the controller is electrically connected with the multiple electrode slices. By installing the uniform pressing mechanism, uniform massage is achieved, the pressing position of the air bag is changed, the whole limb is pressed uniformly, the pressing strength of all parts of the limb is prevented from being different, the problem that the whole limb is pressed unevenly is effectively solved, and therefore lymph circulation is more efficiently promoted.

The invention relates to the technical field of medical instruments, and provides a lymphedema therapeutic apparatus with a self-cleaning device and a cleaning method.The lymphedema therapeutic apparatus comprises a therapeutic apparatus body, a cleaning device body is movably arranged in the therapeutic apparatus body, a vibration device is fixedly arranged in the therapeutic apparatus body, and a sweeping device and a spraying device are arranged in the cleaning device body; through the arrangement of the cleaning device and other structures, a double-shaft motor is started, the double-shaft motor drives a first chain wheel, a chain and a second chain wheel to rotate through a rotating shaft, the chain drives a sliding block to move, the sliding block drives a fixing block to move, and when the fixing block moves to one end of the chain, the sliding block slides in the fixing block so as to move to the chain on the lower portion; and then the fixed block is continuously driven to move reversely, so that the cleaning block is driven to move back and forth to clean the bottom of the therapeutic apparatus body, and the effect of automatic cleaning is achieved. By means of the technical scheme, the problems that in the prior art, no self-cleaning device exists, water resources are wasted during cleaning, and cleaning is inconvenient are solved.

The present invention discloses a portable lymphedema drainage device, and relates to the technical field of lymphedema drainage. The portable lymphedema drainage device comprises a storage device, a sleeve device arranged in the storage device, a pressure device placed in the storage device, and a massager placed on one side of the pressure device. The sleeve device comprises two groups of pressure sleeves, one group of pressure sleeves is an upper limb pressure sleeve, and the other group of pressure sleeves is a lower limb pressure sleeve; both sides of the pressure pump device are respectively provided with hanging parts for connecting with the pressure sleeves. The device can select different massage modes according to the drainage site and environment, improve the selectivity, monitor the massage pressure in real time, adjust the massage pressure according to the needs of the user, improve the correctness and effect of lymphatic drainage, and facilitate medical staff to monitor the use of the equipment in real time, and is easy to store and carry, and convenient for mobile use.

An artificial structure for preventing or treating lymphedema and a construction method therefor. The artificial structure includes a first sheet and a second sheet arranged on the first sheet and including at least two channels. Each channel includes an inlet, an outlet, a one-way channel structure configured to maintain a one-way flow of lymph from the inlet toward the outlet, and a pattern on a surface facing the first sheet. The artificial structure is configured to maintain a normal flow of lymph despite the effects of lymphadenectomy and radiation exposure. The artificial structure has the effect of not only preventing the onset of lymphedema but also effectively being useful for treating diseases caused by interruption of lymph flow.

The invention relates to clinical medicine, and more particularly to lymphology, surgery, plastic surgery and oncology, for treating lymphatic swelling in the case of primary or secondary lymphoedema in adults and children, inter alia accompanied by infectious complications, and even more particularly relates to methods for treating lymphoedema and to the use of accessible drugs in the treatment of lymphatic swelling at any stage and in any location. The claimed method for the lymphotropic treatment of lymphoedema involves consecutively preparing an injectable drug composition A containing an adrenergic alpha-1 receptor agonist and a glucocorticoid, administering same by lymphotropic interstitial injection by puncturing the interstitial tissue of the lymphatic region of interest and introducing the drug composition, preparing an injectable drug composition B containing a cholinesterase inhibitor, administering same by lymphotropic interstitial injection by puncturing the interstitial tissue of the lymphatic region of interest and introducing the drug composition, and also, if necessary, preparing an injectable drug composition C containing bovhyaluronidase azoximer, and administering same by interstitial injection by puncturing the interstitial tissue of the lymphatic region of interest. The technical result consists in improving the drainage of free fluid from the tissues and reducing limb swelling in the case of lymphoedema.

The present invention relates to a method for constructing a lymphedema pathological network based on graph neural networks. First, collect medical imaging data, clinical records, and biomarker data of the lymphatic system of patients, and use image processing techniques to extract key features and structure them into nodes and edges of a graph; then, based on the anatomical structure and physiological functions of the lymphatic system, define the topological structure of the graph, and introduce multi-modal data fusion technology to combine imaging data and biomarker data; then, design a multi-layer graph convolutional network model for learning the patterns of lymph nodes and their connections, and introduce an attention mechanism; then, use the graph convolutional network for deep learning to extract hidden features of nodes and edges, and apply graph embedding technology to transform high-dimensional graph data into a low-dimensional space; finally, develop a graph-based anomaly detection algorithm for identifying pathological changes that are significantly different from common patterns, and combine time series analysis to predict the pathological progression of lymphedema.

The invention belongs to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition for promoting blood circulation to remove blood stasis and inducing diuresis to alleviate edema and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 25-35 parts of radix angelicae sinensis, 10-15 parts of rhizoma chuanxiong, 10-20 parts of radix paeoniae rubra, 25-35 parts of semen coicis, 10-20 parts of rhizoma atractylodis macrocephalae, 10-15 parts of rhizoma atractylodis, 15-25 parts of radix astragali, 10-20 parts of poria cocos, 10-15 parts of polyporus umbellatus, 10-15 parts of radix cyathulae, 10-15 parts of rhizoma alismatis and 15-25 parts of flos lonicerae. The raw materials are wide in source, all the medicines are used together to achieve the effects of promoting blood circulation to remove blood stasis and inducing diuresis to alleviate edema, the synergistic interaction effect of the medicines is fully achieved, and the traditional Chinese medicine composition has the positive treatment effect on diseases such as lymphedema, varicose vein with edema of lower limbs and deep vein thrombosis.

The invention relates to application of an EZH2 inhibitor in preparation of a medicine for preventing and / or treating lymphedema. Experiments prove that the EZH2 inhibitor can remarkably inhibit the skin fibrosis symptom of a lymphedema subject for the first time, so that the progress of the lymphedema can be effectively blocked, and the purposes of relieving, relieving and / or improving the lymphedema and related symptoms are achieved. In addition, the inventor also finds that the EZH2 inhibitor has relatively good medication safety. Therefore, the EZH2 inhibitor is expected to become a candidate therapeutic drug for lymphedema and has great clinical application prospect and value.

Described are methods of treating lipedema in a patient in need thereof comprising administering a selective LTA4H inhibitor in a therapeutically effective amount. Also described are methods of treating a lymphatic dysfunction-associated abnormality of subcutaneous tissue or lymphatic disease of the subcutaneous tissue in a patient in need thereof comprising administering to said patient a therapeutically effective amount of a selective LTA4H inhibitor. In addition, methods of preventing or lowering the risk of developing lymphedema in a patient in need thereof are described.

The invention provides a limb lymphedema air pressure detector, and mainly relates to the technical field of limb lymphedema air pressure detection equipment. A limb lymphedema air pressure detector comprises a machine shell, supporting legs arranged at the bottom of the machine shell and a controller, a detection inner cylinder is arranged in the machine shell and communicated with a vacuum pump, an opening communicated with the detection inner cylinder is formed in the center of the top face of the machine shell, an elastic oversleeve is fixedly installed at the top of the opening, and the elastic oversleeve is fixedly connected with the controller. A gas inlet of the vacuum pump is fixedly connected with one end of a gas suction pipe, the other end of the gas suction pipe is communicated with the detection inner cylinder, and a gas volume flowmeter communicated with the gas suction pipe is arranged in the middle of the gas suction pipe. The device has the advantages that a negative pressure environment is formed through air exhaust of the vacuum pump, the air exhaust amount is measured in real time through the gas volume flow meter, the volume of limbs can be accurately measured, and compared with a traditional water replacement method, the water surface height reading error is avoided, and the edema degree detection accuracy is greatly improved.

The invention relates to a blood protein peptide composition for improving body type and posture symptoms, and belongs to the field of bioactive peptides. The blood protein peptide composition disclosed by the invention comprises an LMN polypeptide and an LTL polypeptide, the amino acid sequence of the LMN polypeptide is Leuu-Met-Asn; the amino acid sequence of the LTL polypeptide is Leuu-Thr-Leu (Leu-Thr-Leu). The blood protein peptide composition prepared by using the technical scheme of the invention can improve body type and posture symptoms caused by lymphedema, and shows good economic benefits and social benefits.

The present disclosure relates to an artificial structure for preventing or treating lymphedema and a construction method therefor. According to the artificial structure for preventing or treating lymphedema and the construction method therefor in accordance with an aspect, despite the effects of lymphadenectomy and radiation exposure, the flow of lymph fluid is maintained similarly to normal by the artificial structure, whereby the artificial structure has the effect of not only preventing the onset of lymphedema but also effectively being useful for treating diseases caused by interruption of lymph flow.

Systems, devices, and methods of connecting two anatomical structures to facilitate fluid communication between the structures may utilize percutaneous and / or endovascular entry routes to the anatomical structures so that they may be positioned proximate to one another and a channel for facilitating fluid communication between them may be formed. In some cases, a first anatomical structure is a vein and a second anatomical structure is a lymph node and, in these instances, the lymph node may be positioned proximate to the vein so that a channel that allows lymphatic fluid to drain into the vein may be formed as a way of treating and / or preventing lymphedema.

The utility model discloses a sliding type accurate positioning and measuring device for leg circumference and arm circumference of a lymphedema patient. The sliding type accurate positioning and measuring device comprises a first bearing plate, a second bearing plate, a baffle and a measuring assembly. The two sides of the upper surface of the first bearing plate are each provided with a first scale line, and the first scale lines extend in the length direction of the first bearing plate. The second bearing plate is connected to the tail end of the first bearing plate in a pivoted mode, the second bearing plate can be switched between a first state and a second state, when the second bearing plate is in the first state, the bottom face of the second bearing plate is attached to the bottom face of the first bearing plate, and when the second bearing plate is in the second state, the bottom face of the second bearing plate is attached to the bottom face of the second bearing plate. The upper surface of the second bearing plate and the upper surface of the first bearing plate are located on the same horizontal plane. The baffle is connected to the head end of the first bearing plate in a pivoted mode so as to block the palm or the sole of a patient, the baffle can be switched between a third state and a fourth state, when the baffle is in the third state, the baffle is attached to the upper surface of the first bearing plate, and when the baffle is in the fourth state, the baffle is attached to the lower surface of the first bearing plate. The baffle is perpendicular to the first bearing plate. The measuring assembly comprises a sliding block and a measuring belt, the sliding block is arranged in the middle of the upper surface of the first bearing plate and can slide in the length direction of the first bearing plate, and the measuring belt transversely penetrates through the upper end of the sliding block and can be drawn left and right to measure the arm circumference and the leg circumference. When the second bearing plate is in the second state, the measuring assembly can slide to the surface of the second bearing plate and move in the length direction of the second bearing plate. The device is simple in structure and convenient and accurate in measurement.