The invention discloses a multi-profile linkage clamping mechanism. The multi-profile linkage clamping mechanism comprises a lower bottom plate A, a lower bottom plate B, locating blocks A, locating blocks B, a sliding block, clamping blocks, ribs, a flat double-shaft air cylinder and a connecting piece, wherein the bottom plate A and the bottom plate B are arranged on the two sides of the sliding block, the sliding block, the lower bottom plate A and the lower bottom plate B form a sliding pair, the sliding block is connected with the flat double-shaft air cylinder through the connecting piece, the clamping blocks are arranged on the upper portion of the sliding block, the ribs are arranged on the clamping blocks, and the locating blocks A and the locating blocks B are arranged on the two sides of the sliding block respectively and serve as profile locating references. According to the multi-profile linkage clamping mechanism, the effect that each profile has a reference plane when clamping is carried out is achieved by using the clamping mechanism, locating accuracy is ensured, multiple profiles are fed at one time and located and clamped simultaneously, feeding time and discharging time are saved, labor intensity is lowered, labor efficiency is improved, the requirements for clamping profiles of different types and sizes can be met, and equipment cost can be reduced effectively.