The invention discloses a large wind tunnel test section replacement method. The purpose is to solve the problem that according to an existing wind tunnel test section transportation mode, travellingmechanisms turn inconveniently or positioning is not accurate during replacement. According to the large wind tunnel test section replacement method, test section transportation vehicles are adopted for conducting test section transportation and replacement, a test section is not provided with travelling mechanisms, and through lifting, 90-degree turning of wheels and freely parallel operation ofthe multiple vehicles of the test section transportation vehicles, turning of the wind tunnel test section is achieved; meanwhile, a V-flat slideway mode is adopted for positioning wind tunnel test stations of the test section, round liquid hydrostatic bearings are arranged on the test section transportation vehicles and are used for reducing transverse friction force when the test section falls into a slideway, and through cooperation of the V-flat slideway, the wind tunnel test section and the round liquid hydrostatic bearings, the wind tunnel test section is precisely positioned. By means of the large wind tunnel test section replacement method, the problems that during wind tunnel test section transportation and replacement, positioning is not accurate, and the travelling mechanisms need to turn can be effectively solved, so that the large wind tunnel test section replacement method has a high application value.