The invention discloses a communication talkback waterproof device, comprising an intercom body, an intercom connecting groove, a waterproof outer cover, an intercom slot, connecting flanges, a plurality of buoyancy adjusting assemblies, a portable clamp, a balancing base, portable elastic cords, a draw hook and a pull ring; the intercom connecting groove is arranged on the intercom body, the intercom slot is located inside the waterproof outer cover, and the intercom body is inserted in the waterproof outer cover; the plurality of buoyancy adjusting assemblies are arranged on two sides of the waterproof outer cover, and each buoyancy adjusting assembly includes a transverse rotating shaft, a first inflatable column, a lateral rotating shaft and a second inflatable column; the portable clamp is arranged on the waterproof outer cover, the balancing base is arranged at the bottom of the waterproof outer cover, the portable elastic cords are connected with the portable clamp and the draw hook, and the pull ring and the draw hook are movably fastened. The communication talkback waterproof device provided by the invention can enable the intercom body to float in a balanced manner when falling into water, thereby keeping components inside dry, ensuring normal use, and achieves waterproof, dustproof, shakeproof and other protective effects.