The invention relates to an anti-blocking highway information board with a protection function. The anti-blocking highway information board with the protection function comprises an upper horizontal board, a lower horizontal board, a display board, an antenna, a cleaning box, a protection mechanism and two pillars. The cleaning box is internally provided with a cleaning mechanism, the cleaning mechanism comprises a lifting assembly, a lifting plate, a translating assembly, a translating plate, a cleaning assembly and two connecting rods. The protection mechanism includes a hinged assembly, a first blocking plate, an extension assembly and two driving assemblies. Each driving assembly includes a first motor, a bearing, a first driving shaft, a moving block and a supporting rod. The anti-blocking highway information board with the protection function removes debris adsorbed on the surface of the display board through the cleaning mechanism, and blocking of the information board by the debris is prevented so that people can observe conveniently; and moreover, in hail weather, the upper part of the display board is shielded by the first blocking plate and the second blocking plate through the protection mechanism, the display board from being damaged by the hail is prevented to ensure safe operation of the equipment, and the practicability of the equipment is improved.