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The present invention provides functionalized particles and methods for delivering said particles capable of crossing a physiologic barrier and exerting an effect. In one embodiment, the present invention provides a method of delivering a particle to a mammal comprising the steps of contacting a functionalized particle with a tag and introducing the functionalized and tagged particle to a mammal, wherein the functionalized portion of the particle is selected from the group consisting of acrylic acid, 2-hydroxyethyl acrylate, 2-acrylamido-2-methyl-1-propanesulfonic acid, allylamine, carboxyl group, hydroxyl group, sulfonic group, aldehyde and amine group. The particle is a biodegradable or nodegradable polymer and less than 1.0 mm in diameter.

The present invention generally relates to an improved foam dart that operates with improved accuracy. The shaft of the foam dart is shaped with indentions that direct airflow around the dart to improve its accuracy. The dart tip is also connected through a rigid neck portion that further improves the accuracy of the dart during use. An alternative embodiment allows the user to place a pop cap within the dart tip that will explode to cause a loud bang when the dart contacts a hard object at the end of its flight. Side vents direct exhaust gases away from the target to improve safety.

A semiconductor device and its method of fabrication are described. A trench formed in a semiconductor substrate is partially filling said trench with a semiconductor material that lines a bottom and sides of the trench, leaving a gap in a middle of the trench running lengthwise along the trench. A first portion of the semiconductor material located below the gap is doped with dopants of a first conductivity type. The gap is filled with a dielectric material. Second portions of the semiconductor material located on the sides of the trench on both sides of the dielectric material are doped with dopants of a second conductivity type. The doping forms a P—N—P or N—P—N structure running lengthwise along the trench with differently doped regions located side by side across a width of the trench.

A bed enclosure having a frame, four sidewalls, and a mattress support component suitable for supporting a bed mattress, wherein the bed enclosure is adapted to safely retain within its interior a person who may be prone to falling out of bed or who otherwise may need to be restrained therein, with the bed enclosure having component subframes that can be disassembled for ease of use and storage and sidewalls that can be removed for ease of cleaning, repair, or replacement.

A lever which is used in particular in the field of sports shoes and includes a lever arm 5 which is rotatably associated, at one end, with a support 3 which is rigidly coupled to a flap of the shoe. An auxiliary grip lever 11 for the user is associated with the lever arm at the free end and allows to increase the working length of the lever arm, thus ensuring easier closure thereof.

The present invention generally relates to an improved foam dart that operates with improved accuracy. The shaft of the foam dart is shaped with indentions that direct airflow around the dart to improve its accuracy. The dart tip is also connected through a rigid neck portion that further improves the accuracy of the dart during use. An alternative embodiment allows the user to place a pop cap within the dart tip that will explode to cause a loud bang when the dart contacts a hard object at the end of its flight. Side vents direct exhaust gases away from the target to improve safety.

A pesticide injection system for exterminating insects is provided. The pesticide injection system comprises an applicator; an insert and a plug frictionally engagable with a wall. The applicator includes a pliable bottle for receiving a powder pesticide and a nozzle with an end cap for displacing insulation so the powder pesticide can be injected onto a blind space behind a wall suspected of harboring insects without the powder pesticide contacting the insulation. The means for sealing the nozzle to prevent the powder pesticide from spilling into a living space during use is one of an “O” ring and a ribbed seal. The insert has a plurality of fins engaging a locking tab on the plug. The means for preventing back flow is a check valve. The means for selectively covering a first end of a tube on the plug is one of a door and a cap.

A pesticide injection system for exterminating insects is provided. The pesticide injection system comprises an applicator and a plug frictionally engagable with a wall. The applicator includes a pliable bottle for receiving a powder pesticide and a nozzle for injecting a powder pesticide into a blind space behind a wall suspected of harboring insects without the powder pesticide contacting the insulation. The plug has a check valve to prevent back flow and a door with a door seal to prevent the powder pesticide from spilling into a living space during use. The nozzle has a sleeve biased in a closed position by a sleeve spring for cooperatively exposing a port on the nozzle with an interlocking collar for rotatably engaging a guide on the collar and a tang on the nozzle with a flange on the plug.

The present invention relates to an apparatus to produce oxidizing agent-rich sulfuric acid by electrolysis of sulfuric acid. More specifically, it relates to the apparatus by which dilute sulfuric acid of the specified temperature and concentration is formed within the electrolysis system and then, by electrolysis of the formed dilute sulfuric acid, electrolytic sulfuric acid containing richly oxidizing agent is formed at a high efficiency and safely under the temperature control.

The apparatus for electrolyzing sulfuric acid and the method for electrolyzing sulfuric acid by the present invention comprise the anode side dilute sulfuric acid generation loop A in which concentrated sulfuric acid, as feed material, is diluted and controlled to the specified temperature and concentration, and the anode side electrolytic sulfuric acid generation loop B in which electrolytic sulfuric acid is formed by electrolysis of dilute sulfuric acid with the temperature and concentration controlled to the specified range in the anode side dilute sulfuric acid generation loop A, in, at least, the anode side electrolysis part of the apparatus for electrolyzing sulfuric acid having the anode side electrolysis part and the cathode side electrolysis part.

The process for bioremediation of contaminated sludge including the steps of mixing the contaminated sludge with immature compost in the thermophilic phase; nutrients; inoculants; enzymes and microbes. The mixed composition is composted indoors by microbial breakdown, by controlling temperature; moisture; aeration, porosity and pH. The mixed composition is matured by fungal breakdown, by setting the mixed composition outdoors in windrows. The mixed composition is then stabilized by spreading it on a soil surface in a layer of less than one meter thick.

Triacetone triperoxide (TATP) and other explosives of the peroxide family are safely degraded in situ. Nano and micron size metal particles in an elemental state include pure iron and magnesium or iron and magnesium particles that are mechanically alloyed with palladium and nickel. The metal particles are used in both the elemental state and in emulsions that are made from water, a hydrophobic solvent, such as corn oil, and a food-grade nonionic surfactant. The neat metals and emulsified zero valent metals (EZVM) safely degrade TATP with the major degradation product being acetone. The EZVM system absorbs and dissolves the TATP into the emulsion droplets where TATP degradation occurs. EZVM systems are ideal for degrading dry TATP crystals that may be present on a carpet or door entrance. Both the neat metal system and the emulsion system (EZVM) degrade TATP in an aqueous slurry.

The present invention provides novel crystalline forms of niraparib tosylate. Specific crystalline forms provided by the present invention include niraparib tosylate Form APO-I, a co-crystal of niraparib tosylate and urea, and niraparib tosylate Form APO-II, a co-crystal of niraparib tosylate and oxalic acid. Also provided are pharmaceutical compositions including the niraparib tosylate crystalline forms, and the use of these forms in treatment or prevention of conditions which can be ameliorated by the inhibition of poly(ADP-ribose) polymerase (PARP), in particular certain forms of cancer.

The present invention discloses a baby carrier including a back strap and a vest. The back strap includes at least one first connecting component and at least one second connecting component. The vest includes a vest body, at least one third connecting component and at least one fourth connecting component. The at least one third connecting component and the at least one fourth connecting component respectively are fixed on two ends of the vest body. The at least one third connecting component and the at least one fourth connecting component respectively are detachably connected to the at least one first connecting component and the at least one second connecting component to connect the back strap with the vest. It provides a flexible way for a caregiver to carry a baby comfortably and safely.

A starting control method and system of a fuel cell vehicle are provided. The method includes detecting a cold-running-mode condition including a fuel-cell coolant temperature during stoppage of the vehicle and determining whether the coolant temperature is less than a first set value that is preset in a memory. A vehicle restarting process in the memory is then set using information regarding a vehicle state during the stoppage of the vehicle when the coolant temperature is less than the first set value.

The problem of the present invention is to provide a production method for safely synthesizing a nitrogen-containing heterocyclic N-oxide compound in high yield. Another problem of the present invention is to provide a novel N-oxide compound. There is provided a method for producing a nitrogen-containing heterocyclic N-oxide compound of Formula (2), such as 2,2,7,9-tetramethyl-2H-pyrano[2,3-g]quinoline N-oxide, by oxidizing a nitrogen-containing heterocyclic compound of Formula (1), such as 2,2,7,9-tetramethyl-2H-pyrano[2,3-g]quinoline with a persulfate.

The present invention generally relates to an improved foam dart that operates with improved accuracy. The shaft of the foam dart is shaped with indentions that direct airflow around the dart to improve its accuracy. The dart tip is also connected through a rigid neck portion that further improves the accuracy of the dart during use. An alternative embodiment allows the user to place a pop cap within the dart tip that will explode to cause a loud bang when the dart contacts a hard object at the end of its flight.

Provided is a method for synthesizing a rare-earth oxo isopropoxide safely with a high yield, using a rare-earth metal, which is more inexpensive than anhydrous rare-earth chlorides, as a raw material.

In a solvent containing 90% or more by weight of isopropyl alcohol, a rare-earth metal and isopropyl alcohol are caused to react with each other in the presence of a mercury compound catalyst, a solvent is added thereto or the solvent is partially replaced, and then in a solvent containing 25% or more by weight of an aromatic hydrocarbon solvent having 6 to 10 carbon atoms or a saturated hydrocarbon solvent having 5 to 12 carbon atoms, water is added to conduct partial hydrolysis reaction, thereby synthesizing a rare-earth oxoisopropoxide.